Results 51 to 60 of about 227,711 (205)
BiomedicinesBackground/Objectives: Circadian disruption resulting from factors such as jet lag, shift work, or aging leads to exaggerated inflammatory responses and increased disease susceptibility. However, the core dynamical mechanism by which circadian disruption
Quan Zhou, Qi Ouyang, Hongli Wang
doaj +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Active mode subclock power gating
This paper presents a technique, called subclock power gating, for reducing leakage power during the active mode in low performance, energy-constrained applications.
Merrett, Geoff V. +5 more
core +1 more source
Dynamic Power Reduction of Digital Circuits by Clock Gating
, 2020 In this paper we have presented clock gating process for low power VLSI (very large scale integration) circuit design. Clock gating is one of the most quite often used systems in RTL to shrink dynamic power consumption without affecting the performance ...
Varsha Dewre, Int
core
The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function
Cell Reports, 2015 Circadian rhythms regulate many aspects of physiology, ranging from sleep-wake cycles and metabolic parameters to susceptibility to infection. The molecular clock, with transcription factor BMAL1 at its core, controls both central and cell-intrinsic ...
Saskia Hemmers, Alexander Y. Rudensky
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Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Clock-Tree Power Optimization based on RTL Clock-Gating
, 2003 As power consumption of the clock tree in modern VLSI de-signs tends to dominate, measures must be taken to keep it under control. This paper introduces an approach for reduc-ing clock power based on clock gating. We present a method-ology that, starting
Benini, L. +10 more
core +1 more source
, 2008 Clock gating and power gating are two of the most effective techniques that are applied today for reducing dynamic and leakage power, respectively, in digital CMOS circuits.
MACII, Alberto +4 more
core +2 more sources
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Functional analysis of Casein Kinase 1 in a minimal circadian system.
PLoS ONE, 2013 The Earth's rotation has driven the evolution of cellular circadian clocks to facilitate anticipation of the solar cycle. Some evidence for timekeeping mechanism conserved from early unicellular life through to modern organisms was recently identified ...
Gerben van Ooijen +8 more
doaj +1 more source