C-terminal binding protein (CtBP) activates the expression of E-box clock genes with CLOCK/CYCLE in Drosophila. [PDF]
PLoS ONE, 2013 In Drosophila, CLOCK/CYCLE heterodimer (CLK/CYC) is the primary activator of circadian clock genes that contain the E-box sequence in their promoter regions (hereafter referred to as "E-box clock genes").
Taichi Q Itoh +2 more
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Pflügers Archiv - European Journal of Physiology, 2011 In most species--from cyanobacteria to humans--endogenous clocks have evolved that drive 24-h rhythms of behavior and physiology. In mammals, these circadian rhythms are regulated by a hierarchical network of cellular oscillators controlled by a set of clock genes organized in a system of interlocked transcriptional feedback loops.
Landgraf, D., Shostak, A., Oster, H.
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Circadian Rhythms in the CNS and Peripheral Clock Disorders: The Circadian Clock and Hyperlipidemia
Journal of Pharmacological Sciences, 2007 A circadian clock controls various physiological and behavioral rhythms. In mammals, a master circadian clock exists in the suprachiasmatic nucleus of the hypothalamus, and slave oscillators can be found in most tissues.
Takashi Kudo +2 more
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Alternative Splicing of Circadian Clock Genes Correlates With Temperature in Field-Grown Sugarcane [PDF]
, 2019 Alternative Splicing (AS) is a mechanism that generates different mature transcripts from precursor mRNAs (pre-mRNAs) of the same gene. In plants, a wide range of physiological and metabolic events are related to AS, as well as fast responses to changes ...
Alabadí +111 more
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A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]
, 2019 The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica +4 more
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Breast Cancer: Basic and Clinical Research, 2012 This study investigates differences in expression of clock and clock-controlled genes (CCGs) between human breast epithelial and breast cancer cells and breast tumor xenografts in circadian intact rats and examines if the pineal hormone melatonin ...
S. Xiang +8 more
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Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat. [PDF]
PLoS ONE, 2018 Circadian clocks, present in almost all cells of the body, are entrained to rhythmic changes in the environment (e.g. light/dark cycles). Genes responsible for this timekeeping are named core-clock genes, which through transcriptional feedback ...
Panteleimon D Mavroudis +3 more
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Accurate timekeeping is controlled by a cycling activator in Arabidopsis. [PDF]
, 2013 Transcriptional feedback loops are key to circadian clock function in many organisms. Current models of the Arabidopsis circadian network consist of several coupled feedback loops composed almost exclusively of transcriptional repressors.
Devisetty, Upendra K +2 more
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Biologia Plantarum, 2018 Strawberry is an economically important fruit crop worldwide. Circadian clock genes are endogenous timers that regulate a wide range of metabolic processes and consequently plant development.
X. D. Chen, J. Wang, M. Z. Zhao, F. Zhao
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Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle. [PDF]
PLoS ONE, 2018 Numerous peripheral tissues possess self-sustaining daily biologic rhythms that are regulated at the molecular level by clock genes such as PER1, PER2, CLOCK, and BMAL1.
Ha Kyun Kim +4 more
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