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Clock gene variants differentiate mood disorders
Molecular Biology Reports, 2014Genetic variations in clock-related genes were hypothesized to be involved to in the susceptibility of mood disorders MD (both unipolar (UPD) and bipolar (BPD) disorders). In our work we investigated role of gene variants form four core period proteins: CLOCK, ARNTL, TIM and PER3. The total sample comprised from 744 mood disorders inpatients (UPD = 229,
Monika Paulina, Dmitrzak-Weglarz +7 more
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Clock Gene Evolution and Functional Divergence
Journal of Biological Rhythms, 2004In considering the impact of the earth’s changing geophysical conditions during the history of life, it is surprising to learn that the earth’s rotational period may have been as short as 4 h, as recently as 1900 million years ago (or 1.9 billion years ago).
Tauber, E +3 more
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Trends in Genetics, 2001
Researchers investigating a rare genetic sleep disorder have identified the first human gene that controls circadian rhythm. Familial advanced sleep-phase syndrome (FASPS) causes sufferers to both fall asleep and wake up about fours hours in advance of the general population.
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Researchers investigating a rare genetic sleep disorder have identified the first human gene that controls circadian rhythm. Familial advanced sleep-phase syndrome (FASPS) causes sufferers to both fall asleep and wake up about fours hours in advance of the general population.
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Nihon rinsho. Japanese journal of clinical medicine, 2009
Urs Albrecht, Jürgen A. Ripperger
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Urs Albrecht, Jürgen A. Ripperger
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Science, 1995
Organisms from simple, single-celled bacteria to complex mammals have internal biochemical clocks that maintain the daily cycles of behavior known as circadian rhythms. In three reports published in this issue of Science (pp. 805 , 808 , and 811
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Organisms from simple, single-celled bacteria to complex mammals have internal biochemical clocks that maintain the daily cycles of behavior known as circadian rhythms. In three reports published in this issue of Science (pp. 805 , 808 , and 811
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Clocked gene expression in somite formation
BioEssays, 1998A recent paper describes a striking expression pattern during somite formation for a chick ortholog of the fly hairy gene. Before segmentation, c-hairy1 mRNA oscillates in the presomitic mesoderm such that three distinct spatial patterns are seen. The authors use a series of ingenious manipulations to show that these phases follow each other in time ...
C D, Stern, D, Vasiliauskas
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[Clock genes and clock-controlled genes in mammals].
Nihon rinsho. Japanese journal of clinical medicine, 2012The suprachiasmatic nucleus (SCN) is considered the master circadian pacemaker that controls most of the physical circadian rhythms of mammals including behavior. Studies of clock genes have implied that oscillatory mechanisms function in peripheral organs and isolated cells, and that they are entrained to the SCN.
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2017
Mismatch between the external time and the internal circadian time causes loss of circadian organization and is frequently linked to cancer. This chapter describes the role of the molecular circadian clock in the incidence and progression of cancer. The first section will present the strong association between disrupted clock gene expression in either ...
Silke Kiessling, Nicolas Cermakian
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Mismatch between the external time and the internal circadian time causes loss of circadian organization and is frequently linked to cancer. This chapter describes the role of the molecular circadian clock in the incidence and progression of cancer. The first section will present the strong association between disrupted clock gene expression in either ...
Silke Kiessling, Nicolas Cermakian
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Clock genes in mammalian peripheral tissues
Cell and Tissue Research, 2002For many years, neurons of the suprachiasmatic nucleus (SCN) in the hypothalamus were thought to contain the unique mammalian clock controlling circadian rhythmicity of peripheral tissues via neural and humoral signals. Surprisingly, the cloning and characterisation of mammalian clock genes have revealed that they are expressed in a circadian manner ...
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Circadian-clock regulation of gene expression
Current Opinion in Genetics & Development, 1993During the past year, our understanding of the cellular and molecular processes involved in the generation and control of circadian rhythms has advanced significantly. Progress has been made at the level of the circadian pacemaker mechanism itself, the input pathways that regulate the pacemaker, and the mechanisms by which the pacemaker regulates its ...
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