Results 11 to 20 of about 125,163 (295)

Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches. [PDF]

PLoS ONE, 2014
Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of
Andrés Romanowski, Matías Javier Garavaglia, María Eugenia Goya, Pablo Daniel Ghiringhelli, Diego Andrés Golombek   +4 more
doaj   +10 more sources

Investigations of the CLOCK and BMAL1 Proteins Binding to DNA: A Molecular Dynamics Simulation Study. [PDF]

PLoS ONE, 2016
The circadian locomotor output cycles kaput (CLOCK), and brain and muscle ARNT-like 1 (BMAL1) proteins are important transcriptional factors of the endogenous circadian clock.
Tuo Xue, Chunnian Song, Qing Wang, Yan Wang, Guangju Chen   +4 more
doaj   +1 more source

The Essential and the Nonessential Roles of Four Clock Elements in the Circadian Rhythm of Metarhiziumrobertsii

Journal of Fungi, 2022
FRQ (frequency protein), FRH (FRQ-interacting RNA helicase), and WC1 and WC2 (white collar proteins) are major clock elements that govern the circadian rhythm in Neurosporacrassa. However, deletion of frh is lethal for the viability of N.
Han Peng, Yi-Lu Zhang, Sheng-Hua Ying, Ming-Guang Feng   +3 more
doaj   +1 more source

Circadian Clock Proteins and Immunity [PDF]

Immunity, 2014
Immune parameters change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow an organism to anticipate daily changes in activity and feeding and the associated risk of infection or tissue damage to the host. Responses to bacteria have been shown to vary
Anne M. Curtis, Marina M. Bellet, Paolo Sassone-Corsi, Luke A.J. O’Neill   +3 more
openaire   +4 more sources

Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus. [PDF]

PLoS ONE, 2012
Research on the mechanisms underlying circadian rhythmicity and the response of brain and body clocks to environmental and physiological challenges requires assessing levels of circadian clock proteins.
Joseph LeSauter, Christopher M Lambert, Margaret R Robotham, Zina Model, Rae Silver, David R Weaver   +5 more
doaj   +1 more source

How is the inner circadian clock controlled by interactive clock proteins? [PDF]

FEBS Letters, 2015
Most internationally travelled researchers will have encountered jetlag. If not, working odd hours makes most of us feel somehow dysfunctional. How can all this be linked to circadian rhythms and circadian clocks? In this review, we define circadian clocks, their composition and underlying molecular mechanisms.
Merbitz-Zahradnik, Torsten, Wolf, Eva
openaire   +2 more sources

ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer

Frontiers in Oncology, 2020
ObjectiveTriple-negative (PR−, ER−, HER-2−) breast cancer (TNBC) is regarded as more aggressive and more likely to recur after medical care. Emerging evidence has demonstrated that the circadian clock system regulates cell-signaling pathways critical to ...
FenFen Xie, FenFen Xie, FenFen Xie, FenFen Xie, FenFen Xie, FenFen Xie, LiLi Wang, YaJing Liu, YaJing Liu, YaJing Liu, YaJing Liu, YaJing Liu, ZhenBang Liu, ZuoYang Zhang, Jing Pei, ZhengSheng Wu, MuXin Zhai, YunXia Cao, YunXia Cao, YunXia Cao, YunXia Cao, YunXia Cao   +21 more
doaj   +1 more source

The Clock Proteins, Aging, and Tumorigenesis [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2007
Many aspects of mammalian physiology and behavior are driven by an intrinsic timekeeping system that has an important role in synchronizing various biological processes within an organism and coordinating them with the environment. It is believed that deregulation of this coordination may cause the development of various pathologies.
R V, Kondratov, M P, Antoch
openaire   +2 more sources

Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity

Genes & Development, 2021
In all organisms with circadian clocks, post-translational modifications of clock proteins control the dynamics of circadian rhythms, with phosphorylation playing a dominant role. All major clock proteins are highly phosphorylated, and many kinases have been described to be responsible.
Sabrina Klemz, Thomas Wallach, Sandra Korge, Mechthild Rosing, Roman Klemz, Bert Maier, Nicholas C. Fiorenza, Irem Kaymak, Anna K. Fritzsche, Erik D. Herzog, Ralf Stanewsky, Achim Kramer   +11 more
openaire   +3 more sources

Circadian clock cryptochrome proteins regulate autoimmunity [PDF]

Proceedings of the National Academy of Sciences, 2017
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [ Cry double knockout (DKO)] develop an autoimmune phenotype including high serum IgG concentrations,
Cao, Qi, Zhao, Xuan, Bai, Jingwen, Gery, Sigal, Sun, Haibo, Lin, De-Chen, Chen, Qi, Chen, Zhengshan, Mack, Lauren, Yang, Henry, Deng, Ruishu, Shi, Xianping, Chong, Ling-Wa, Cho, Han, Xie, Jianjun, Li, Quan-Zhen, Müschen, Markus, Atkins, Annette R, Liddle, Christopher, Yu, Ruth T, Alkan, Serhan, Said, Jonathan W, Zheng, Ye, Downes, Michael, Evans, Ronald M, Koeffler, H Phillip   +25 more
openaire   +4 more sources