Results 21 to 30 of about 47,534 (163)

Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals. [PDF]

PLoS ONE, 2008
In mammals, the circadian clock relies on interlocked feedback loops involving clock genes and their protein products. Post-translational modifications control intracellular trafficking, functionality and degradation of clock proteins and are keys to the
Hugues Dardente, Jorge Mendoza, Jean-Michel Fustin, Etienne Challet, David G Hazlerigg   +4 more
doaj   +1 more source

Drosophila RSK Influences the Pace of the Circadian Clock by Negative Regulation of Protein Kinase Shaggy Activity

Frontiers in Molecular Neuroscience, 2018
Endogenous molecular circadian clocks drive daily rhythmic changes at the cellular, physiological, and behavioral level for adaptation to and anticipation of environmental signals.
Katherina Beck, Anna Hovhanyan, Pamela Menegazzi, Charlotte Helfrich-Förster, Thomas Raabe   +4 more
doaj   +1 more source

Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. [PDF]

PLoS ONE, 2012
Spermatogenesis is a complex differentiation process that involves genetic and epigenetic regulation, sophisticated hormonal control, and extensive structural changes in male germ cells.
Rita L Peruquetti, Sara de Mateo, Paolo Sassone-Corsi   +2 more
doaj   +1 more source

Direct regulation of CLOCK expression by REV-ERB. [PDF]

PLoS ONE, 2011
Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY).
Christine Crumbley, Thomas P Burris
doaj   +1 more source

Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction

Nature Communications, 2022
PERIOD proteins, the core components of the mammalian circadian clock, act as the CK1 scaffold in the negative feedback process. Surprisingly, the mouse circadian clock can function independent of PER phosphorylation and PER abundance rhythms.
Yang An, Baoshi Yuan, Pancheng Xie, Yue Gu, Zhiwei Liu, Tao Wang, Zhihao Li, Ying Xu, Yi Liu   +8 more
doaj   +1 more source

Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit

Cell Communication and Signaling, 2020
Introduction The circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced organismal survival by facilitating the anticipation of the day/night cycle.
Jacqueline F. Pelham, Jay C. Dunlap, Jennifer M. Hurley   +2 more
doaj   +1 more source

Repressor dimerization in the zebrafish somitogenesis clock. [PDF]

PLoS Computational Biology, 2007
The oscillations of the somitogenesis clock are linked to the fundamental process of vertebrate embryo segmentation, yet little is known about their generation.
Olivier Cinquin
doaj   +1 more source

Acute hypoxia induced dysregulation of clock-controlled ovary functions

Frontiers in Physiology, 2022
High altitudes or exposure to hypoxia leads to female reproductive disorders. Circadian clocks are intrinsic time-tracking systems that enable organisms to adapt to the Earth’s 24-h light/dark cycle, which can be entrained by other environmental stimuli ...
Mengnan Ding, Yarong Lu, Yarong Lu, Xin Huang, Chen Xing, Shaojun Hou, Shaojun Hou, Shaojun Hou, Dongxue Wang, Dongxue Wang, Yifan Zhang, Wei Wang, Wei Wang, Chongchong Zhang, Chongchong Zhang, Min Zhang, Min Zhang, Fanfei Meng, Kun Liu, Guangchao Liu, Jincheng Zhao, Lun Song, Lun Song, Lun Song, Lun Song   +24 more
doaj   +1 more source

A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals.  Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo.
Maud Gillessen, Pieter Bas Kwak, Alfred Tamayo   +2 more
doaj   +1 more source

PSMD11 modulates circadian clock function through PER and CRY nuclear translocation.

PLoS ONE, 2023
The molecular circadian clock is regulated by a transcriptional translational feedback loop. However, the post-translational control mechanisms are less understood. The NRON complex is a large ribonucleoprotein complex, consisting of a lncRNA and several
Sibel Cal-Kayitmazbatir, Lauren J Francey, Yool Lee, Andrew C Liu, John B Hogenesch   +4 more
doaj   +1 more source