Results 21 to 30 of about 127,418 (322)
Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity
Genes & Development, 2021 In all organisms with circadian clocks, post-translational modifications of clock proteins control the dynamics of circadian rhythms, with phosphorylation playing a dominant role. All major clock proteins are highly phosphorylated, and many kinases have been described to be responsible.
Sabrina Klemz +11 more
openaire +3 more sources
Transcriptional Feedback Loops in the Caprine Circadian Clock System
Frontiers in Veterinary Science, 2022 The circadian clock system is based on interlocked positive and negative transcriptional and translational feedback loops of core clock genes and their encoded proteins.
Dengke Gao +23 more
doaj +1 more source
Circadian clock cryptochrome proteins regulate autoimmunity [PDF]
Proceedings of the National Academy of Sciences, 2017 The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [ Cry double knockout (DKO)] develop an autoimmune phenotype including high serum IgG concentrations,
Cao, Qi +25 more
openaire +4 more sources
Thermodynamics of Neutral Protein Evolution [PDF]
, 2006 Naturally evolving proteins gradually accumulate mutations while continuing to fold to thermodynamically stable native structures. This process of neutral protein evolution is an important mode of genetic change, and forms the basis for the molecular ...
Bloom, Jesse D +2 more
core +2 more sources
Scientific Reports, 2023 Across the three domains of life, circadian clock is known to regulate vital physiological processes, like, growth, development, defence etc. by anticipating environmental cues.
Vikram Singh, Vikram Singh
doaj +1 more source
Diel pattern of circadian clock and storage protein gene expression in leaves and during seed filling in cowpea (Vigna unguiculata) [PDF]
, 2018 Background Cowpea (Vigna unguiculata) is an important source of protein supply for animal and human nutrition. The major storage globulins VICILIN and LEGUMIN (LEG) are synthesized from several genes including LEGA, LEGB, LEGJ and CVC (CONVICILIN).
Egea Gutiérrez-Cortines, Marcos +6 more
core +4 more sources
Stabilizing daily clock proteins [PDF]
Biochemical Journal, 2006 Biological timekeeping is determined by internal temporal programmes and the resetting of these programmes or clocks by external stimuli. Many of the core genes of the mammalian daily or circadian clock are known, but the factors regulating so-called ‘clock’ gene proteins are unclear.
openaire +3 more sources
Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK [PDF]
BMC Molecular Biology, 2008 Circadian oscillation of clock-controlled gene expression is mainly regulated at the transcriptional level. Heterodimers of CLOCK and BMAL1 act as activators of target gene transcription; however, interactions of PER and CRY proteins with the heterodimer abolish its transcriptional activation capacity.
Langmesser, Sonja +4 more
openaire +3 more sources
Frontiers in Plant Science, 2018 Various responses to static magnetic fields (MF) have been reported in plants, and it has been suggested that the geomagnetic field influences plant physiology. Accordingly, diverse mechanisms have been proposed to mediate MF effects in plants.
Jacques Vanderstraeten +3 more
doaj +1 more source
The genetic equidistance result of molecular evolution is independent of mutation rates [PDF]
, 2008 The well-established genetic equidistance result shows that sister species are approximately equidistant to a simpler outgroup as measured by DNA or protein dissimilarity.
Shi Huang
core +3 more sources