Results 71 to 80 of about 108,470 (277)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Pollution profiling and particle size distribution within permeable paving units – with and without a geotextile [PDF]

, 2012
The aim of this paper is to investigate the sediment and pollution profiling and particle size distribution with depth within permeable paving structures, both with and without a geotextile.
Jefferies, Chris, Mullaney, Jennifer, Rikalainen, Päivi   +2 more
core   +3 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Hydraulic Performance of Pervious Concrete Based on Small Size Aggregates

Advances in Materials Science and Engineering, 2022
The paper aims to study the impact of clogging on pervious concrete mixes and explore a simple method to calculate permeability and clogging using the falling head method in a fabricated unit. The materials used are cementitious materials and aggregates,
Arega Mulu, Preeti Jacob, G. S. Dwarakish   +2 more
doaj   +1 more source

Gradient Clogging in Depth Filtration

, 1998
We investigate clogging in depth filtration, in which a dirty fluid is ``cleaned'' by the trapping of dirt particles within the pore space during flow through a porous medium.
A. O. Imdakm, B. Kahng, C. Ghidaglia, C. Ghidaglia, C. Tien, C. Tien, D. G. Harlow, D. Houi, D. Sornette, H. E. Daniels, J. Dodds, J. Galambos, J. H. D. Hampton, J. Lee, L. de Arcangelis, L. M. Schwartz, M. M. Sharma, M. M. Sharma, M. M. Sharma, M. Sahimi, M. Sahimi, P. L. Leath, P. M. Duxbury, S. L. Phoenix, S. Redner, Somalee Datta, W. A. Curtin   +26 more
core   +1 more source

Redefining the role of obstacles in pedestrian evacuation [PDF]

, 2018
The placement of obstacles in front of doors is believed to be an effective strategy to increase the flow of pedestrians, hence improving the evacuation process.
Garcimartín, A., Martín Gómez, C., Maza, D., Parisi, Daniel Ricardo, Pastor, J. M., Zuriguel, I.   +5 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source