Results 291 to 300 of about 3,725,865 (331)

Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion. [PDF]

Sci Transl Med
Rodrigues KA, Zhang YJ, Lam J, Aung A, Morgan DM, Romanov A, Maiorino L, Yousefpour P, Gibson G, Ozorowski G, Gregory JR, Amlashi P, Van R, Buckley M, Ward AB, Schief WR, Love JC, Irvine DJ.   +17 more
europepmc   +1 more source

Cell-autonomous dysregulation of interferon signaling drives clonal expansion of SRSF2-mutant MDS stem/progenitor cells.

Blood
Takashima K, Olszewska M, Jethalia V, Sirenko M, Silverman L, Tomalin LE, Carcamo S, Hasson D, Papapetrou EP.   +8 more
europepmc   +1 more source

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Clonal expansion in non-cancer tissues

Nature Reviews Cancer, 2021
Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are positively selected by acquisition of 'driver mutations'. However, the evolution of positively selected clones does not necessarily imply the presence of cancer.
N. Kakiuchi, S. Ogawa
semanticscholar   +3 more sources

Macroscopic somatic clonal expansion in morphologically normal human urothelium

Science, 2020
Genetic profiles of the bladder Depending on the environment of the individual, the human bladder can be exposed to carcinogens as they are flushed through the body. Lawson et al. and Li et al.
Ruoyan Li, Yi-Qing Du, Zhang-Hua Chen, De-Shu Xu, Tian-Xin Lin, Shanzhao Jin, Gongwei Wang, Zi-Yang Liu, Min Lu, Xu Chen, Tao Xu, F. Bai   +11 more
semanticscholar   +1 more source

“Let”-ing go with clonal expansion?

Blood, 2011
In this issue of Blood, Ikeda et al report the effects of the high mobility group A2 (Δhmga2) lacking the 3' untranslated region (UTR) in hematopoietic tissues. Overexpression of Δhmga2 in transgenic mice resulted in "big mice with big blood": the mice weighed more and had a myeloproliferative phenotype with increases in peripheral blood counts ...
Linda M, Resar, Robert A, Brodsky
openaire   +2 more sources

On the parameters of the clonal expansion model

Radiation and Environmental Biophysics, 1996
The exact hazard function of the clonal expansion model was analyzed, and it was shown that only three of its four parameters can be determined by fitting to the age dependence of spontaneous tumor incidence rates. The same holds for the survival function.
openaire   +2 more sources

Clonal Integration and the Expansion of Phragmites australis

Ecological Applications, 2000
The recent expansion of the reed Phragmites australis in western Atlantic salt marshes has become a conservation concern. Historically, Phragmites was restricted to the terrestrial border of marshes, but now it aggressively invades lower elevations.
Lindsay Amsberry, Michael A. Baker, Patrick J. Ewanchuk, Mark D. Bertness   +3 more
openaire   +1 more source

Clonal Expansion of Lipopolysaccharide-Stimulated B Lymphocytes

The Journal of Immunology, 1974
Abstract The effect of lipopolysaccharide from Gram-negative bacteria (LPS) on the activation and clonal expansion of B cell precursors specific for SRC has been studies in a microculture system. Results indicate that LPS can activate the precursor cells to antibody production in the absence of antigen and without ...
Quintans, J, Lefkovits, I
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Clonal expansions of B lymphocytes in old mice

The Journal of Immunology, 1997
Abstract The effect of age on the diversity of the murine Ig heavy chain repertoire has been studied in unimmunized C57BL/6 mice. We examined the heterogeneity of complementarity-determining region 3 (CDR3) sizes of Ig mRNA of the IgM and IgG isotypes using two VH families, VHJ558 and VHQ52, which together account for approximately 65%
J, LeMaoult, S, Delassus, R, Dyall, J, Nikolić-Zugić, P, Kourilsky, M E, Weksler   +5 more
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Evolution of B-cell clonal expansions with age

Cellular Immunology, 2004
B-cell clonal expansions (BCE) in young mice are transient, detectable for less than 4 weeks. In contrast, BCE in old mice persist more than 2 months. The greater persistence of BCE in old mice does not appear to be due to the age of the host as the survival of phenyloxazolone chicken serum albumin-induced BCE in most old mice was shorter than in young
Paul, Szabo, Fang, Li, Joel, Mathew, Joel, Matthew, John, Lillvis, Marc E, Weksler   +5 more
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