Results 301 to 310 of about 3,725,865 (331)
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Persistent clonal areas and clonal expansion in Barrett's esophagus.
Cancer research, 1992Three patients with Barrett's esophagus who had cytogenetic abnormalities detected in their metaplastic epithelium developed high-grade dysplasia or adenocarcinoma during prospective surveillance over a period of 1.5 to 6 years. In the 3 cases, cytogenetic abnormalities that were associated with the most advanced histological lesions were present in ...
W H, Raskind +5 more
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Modeling Clonal Expansion from M-FISH Experiments
Journal of Computational Biology, 2008A population genetic model is used to describe dynamical aspects of chromosomal abberations observed in M-FISH experiments. Linear differential equations model the evolution of relative frequencies of mutations. The unknown parameters involved are estimated by maximum likelihood methods.
Thomas Stolte +3 more
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Monitoring clonal expansion in the laboratory.
Clinical and experimental rheumatology, 1996The definitive demonstration of the clonal origin of an expanded B or T cell population is achieved by the molecular analysis of B or T cell receptor gene rearrangement. However, in recent years techniques that are both sensitive and relatively easy to carry out have been introduced as the first step to the diagnosis of clonality.
P, Sala, E, Tonutti
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Studies on T Cell Clonal Expansion
The Journal of Immunology, 1975Abstract Spleen cells from C57BL/6 mice immunized with a DBA/2 mastocytoma (P815) were harvested at various stages of the immune response and cultured in vitro in the presence and absence of antigen. Killer T cell activity in immune spleens could not be demonstrated until 6 or 7 days after antigen, but spleen cells ...
Ramesh Kamat, Christopher S Henney
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Deciphering heterogeneity of preleukemic clonal expansion
2022Clonal expansion is a critical step in the early stage of leukemia genesis. While genetic mutations that induce expansion and increase disease risk --such as TET2, DNMT3a, and ASXL-- have been identified, these mutations are also frequently found in healthy individuals and many never progress to malignancy.
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Quantification of Clonal Expansion of Hepatocytes in Normal and Injured Liver
2022A fundamental part of understanding how a tissue regenerates is how individual cells that make up the tissue divide. This protocol describes a method to label a random and representative sampling of hepatocytes throughout the mouse liver and quantify their cell division and clonal expansion during homeostasis and after liver injury. Clonal expansion is
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The Influence of Somatic Mutation on Clonal Expansion
1989The key feature of the process of somatic diversification is that mutations accumulate sequentially during clonal expansion. This was first recognized from the hierarchy of shared mutations in antibodies from clonally related lymphocytes (McKean et al.
M. J. Shlomchik, S. Litwin, M. Weigert
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A new fate mapping system reveals context-dependent random or clonal expansion of microglia
Nature Neuroscience, 2017Tuan-Leng Tay +19 more
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