Results 301 to 310 of about 2,119,256 (322)

“Let”-ing go with clonal expansion?

Blood, 2011
In this issue of Blood, Ikeda et al report the effects of the high mobility group A2 (Δhmga2) lacking the 3' untranslated region (UTR) in hematopoietic tissues. Overexpression of Δhmga2 in transgenic mice resulted in "big mice with big blood": the mice weighed more and had a myeloproliferative phenotype with increases in peripheral blood counts ...
Linda M, Resar, Robert A, Brodsky
openaire   +2 more sources

Clonal Expansion of Lipopolysaccharide-Stimulated B Lymphocytes

The Journal of Immunology, 1974
Abstract The effect of lipopolysaccharide from Gram-negative bacteria (LPS) on the activation and clonal expansion of B cell precursors specific for SRC has been studies in a microculture system. Results indicate that LPS can activate the precursor cells to antibody production in the absence of antigen and without ...
Quintans, J, Lefkovits, I
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Studies on T Cell Clonal Expansion

The Journal of Immunology, 1975
Abstract Spleen cells from C57BL/6 mice immunized with a DBA/2 mastocytoma (P815) were harvested at various stages of the immune response and cultured in vitro in the presence and absence of antigen. Killer T cell activity in immune spleens could not be demonstrated until 6 or 7 days after antigen, but spleen cells ...
Ramesh Kamat, Christopher S Henney
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Deciphering heterogeneity of preleukemic clonal expansion

2022
Clonal expansion is a critical step in the early stage of leukemia genesis. While genetic mutations that induce expansion and increase disease risk --such as TET2, DNMT3a, and ASXL-- have been identified, these mutations are also frequently found in healthy individuals and many never progress to malignancy.
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Evolution of B-cell clonal expansions with age

Cellular Immunology, 2004
B-cell clonal expansions (BCE) in young mice are transient, detectable for less than 4 weeks. In contrast, BCE in old mice persist more than 2 months. The greater persistence of BCE in old mice does not appear to be due to the age of the host as the survival of phenyloxazolone chicken serum albumin-induced BCE in most old mice was shorter than in young
Paul, Szabo, Fang, Li, Joel, Mathew, Joel, Matthew, John, Lillvis, Marc E, Weksler   +5 more
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Effect of antiviral treatment on hepatitis B virus integration and hepatocyte clonal expansion.

Clinical Infectious Diseases, 2022
N. Chow, D. Wong, Ching‐lung Lai, L. Mak, James Fung, H. Ma, Mengyang Lei, W. Seto, M. Yuen   +8 more
semanticscholar   +1 more source

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Nature, 2023
J. Weinstock, Jayakrishnan Gopakumar, B. Burugula, M. Uddin, Nikolaus Jahn, J. Belk, H. Bouzid, Bence Daniel, Zhuang Miao, Nghi Ly, T. Mack, Sofia E. Luna, Katherine P Prothro, Shaneice R Mitchell, C. Laurie, J. Broome, K. Taylor, Xiuqing Guo, Moritz F. Sinner, Aenne S. von Falkenhausen, S. Kääb, A. Shuldiner, J. O’Connell, J. Lewis, E. Boerwinkle, K. Barnes, Nathalie Chami, E. Kenny, R. Loos, M. Fornage, L. Hou, D. Lloyd-Jones, S. Redline, B. Cade, B. Psaty, J. Bis, J. Brody, E. Silverman, J. Yun, D. Qiao, Nicholette D. Palmer, B. Freedman, D. Bowden, M. Cho, D. Demeo, R. Vasan, L. Yanek, L. Becker, S. Kardia, P. Peyser, Jiang He, M. Rienstra, P. van der Harst, R. Kaplan, S. Heckbert, N. Smith, K. Wiggins, D. Arnett, M. Irvin, H. Tiwari, M. Cutler, S. Knight, J. Muhlestein, A. Correa, L. Raffield, Yan Gao, M. de Andrade, J. Rotter, S. Rich, R. Tracy, B. Konkle, J. Johnsen, Marsha M. Wheeler, J. Smith, O. Melander, P. M. Nilsson, B. Custer, R. Duggirala, J. Curran, J. Blangero, S. McGarvey, L. Williams, S. Xiao, Mao Yang, C. Gu, Y. Chen, Wen-Jane Lee, G. Marcus, J. Kane, C. Pullinger, M. B. Shoemaker, D. Darbar, D. Roden, Christine Albert, C. Kooperberg, Yingxiao Zhou, J. Manson, Pinkal M. Desai, Andrew D. Johnson, R. Mathias, T. Blackwell, G. Abecasis, A. Smith, H. M. Kang, Ansuman T. Satpathy, P. Natarajan, J. Kitzman, E. Whitsel, A. Reiner, A. Bick, S. Jaiswal   +110 more
semanticscholar   +1 more source

Persistent clonal areas and clonal expansion in Barrett's esophagus.

Cancer research, 1992
Three patients with Barrett's esophagus who had cytogenetic abnormalities detected in their metaplastic epithelium developed high-grade dysplasia or adenocarcinoma during prospective surveillance over a period of 1.5 to 6 years. In the 3 cases, cytogenetic abnormalities that were associated with the most advanced histological lesions were present in ...
W H, Raskind, T, Norwood, D S, Levine, R C, Haggitt, P S, Rabinovitch, B J, Reid   +5 more
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On the parameters of the clonal expansion model

Radiation and Environmental Biophysics, 1996
The exact hazard function of the clonal expansion model was analyzed, and it was shown that only three of its four parameters can be determined by fitting to the age dependence of spontaneous tumor incidence rates. The same holds for the survival function.
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Adaptive Clonal Expansion Shapes Brain Development

AbstractEmbryonic neural stem/progenitor cells (NSPCs) exhibit remarkable proliferative plasticity, allowing them to fully recover neuronal populations even after substantial cell loss1,2. However, it remains unclear whether all embryonic NSPCs respond to brain lesions.
Giulia Di Muzio, Sarah Benedetto, Li-Chin Wang, Lea Weber, Franciscus van der Hoeven, Brittney Armstrong, Hsin-Jui Lu, Jana Berlanda, Verena Körber, Nina Claudino, Michelle Krogemann, Thomas Höfer, Pei-Chi Wei   +12 more
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