Results 261 to 270 of about 41,259 (301)
Some of the next articles are maybe not open access.
Clinics in Laboratory Medicine, 2023
Premalignant clonal hematopoiesis is the presence of somatic alterations in the blood of otherwise healthy individuals. Although the condition is not considered as a cancer, it carries an increased risk of developing a hematologic malignancy, particularly in those with large neoplastic clones, multiple pathogenic mutations, and high-risk mutations.
Kelly E, Craven, Mark D, Ewalt
openaire +2 more sources
Premalignant clonal hematopoiesis is the presence of somatic alterations in the blood of otherwise healthy individuals. Although the condition is not considered as a cancer, it carries an increased risk of developing a hematologic malignancy, particularly in those with large neoplastic clones, multiple pathogenic mutations, and high-risk mutations.
Kelly E, Craven, Mark D, Ewalt
openaire +2 more sources
Germline predisposition to clonal hematopoiesis
Leukemia Research, 2023We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs) acquire mutations that confer a fitness advantage and clonally expand in a process now termed clonal hematopoiesis (CH). Because CH predisposes to a variety of health problems, including cancers, cardiovascular diseases, and inflammatory conditions, there is intense ...
Jie, Liu +3 more
openaire +2 more sources
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2021
Clonal hematopoiesis (CH) harboring a leukemia-related mutation has been recently found in about 10% of healthy elderly individuals, which has been attracting attention. Although most people with CH do not develop hematological malignancies, some may develop hematological malignancies 10 times more frequently than age-matched controls.
openaire +1 more source
Clonal hematopoiesis (CH) harboring a leukemia-related mutation has been recently found in about 10% of healthy elderly individuals, which has been attracting attention. Although most people with CH do not develop hematological malignancies, some may develop hematological malignancies 10 times more frequently than age-matched controls.
openaire +1 more source
Clonal hematopoiesis and autoimmunity
Seminars in HematologyClonal hematopoiesis (CH) has been associated with aging, occurring in about 10% of individuals aged >70 years, and immune dysfunction. Aged hematopoietic stem and progenitor cells exhibit pathological changes in immune function and activation of inflammatory pathways.
Ashwin Kishtagari +2 more
openaire +2 more sources
ASXL1 mutation in clonal hematopoiesis
Experimental Hematology, 2020Recent advances in DNA sequencing technologies have enhanced our knowledge about several diseases. Coupled with easy accessibility to blood samples, hematology plays a leading role in understanding the process of carcinogenesis. Clonal hematopoiesis (CH) with somatic mutations is observed in at least 10% of people over 65 years of age, without apparent
Takeshi, Fujino, Toshio, Kitamura
openaire +2 more sources
Tipping Clonal Hematopoiesis into Transformation
New England Journal of Medicine, 2018Clonal Hematopoiesis and Hematologic Cancer Clonal hematopoiesis is a risk factor for acute myeloid leukemia and other hematologic cancers.
openaire +2 more sources
Clonal hematopoiesis: Pre-cancer PLUS
2019Clonal hematopoiesis is a common, age-related process in which a somatically mutated hematopoietic precursor gives rise to a genetically distinct subpopulation in the blood. This phenomenon has been observed in populations across the globe and, while virtually non-existent in children is estimated to affect >10% of the 70-and-older age group.
Alexander J, Silver, Siddhartha, Jaiswal
openaire +2 more sources
Germline predisposition for clonal hematopoiesis
Seminars in HematologyClonal hematopoiesis (CH) is an entity hallmarked by skewed hematopoiesis with persistent overrepresentation of cells from a common stem/progenitor lineage harboring single-nucleotide variants and/or insertions/deletions. CH is a common and age-related phenomenon that is associated with an increased risk of hematological malignancies, cardiovascular ...
Yasuo Kubota, Aaron D. Viny
openaire +2 more sources
Clonal Hematopoiesis of Indeterminate Potential
JAMA CardiologyThis JAMA Cardiology Patient Page describes clonal hematopoiesis of indeterminate potential (CHIP).
Peter, Libby, Ohad, Oren, Aeron M, Small
openaire +2 more sources