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Evolution of clonal hematopoiesis

Clinical and Translational Medicine, 2023
Contains fulltext : 300034.pdf (Publisher’s version ) (Open Access)
Isabelle A. van Zeventer, Aniek O. de Graaf, Joop H. Jansen, Gerwin Huls   +3 more
doaj   +5 more sources

Clonal evolution in myelodysplastic syndromes [PDF]

Nature Communications, 2017
Myelodysplastic syndromes are a broad group of haematopoietic malignancies that often progress to acute myeloid leukaemia. Here, the authors show that linear and branched evolution occurs within myelodysplastic syndrome and these patterns can be impacted
Pedro da Silva-Coelho, Leonie I. Kroeze, Kenichi Yoshida, Theresia N. Koorenhof-Scheele, Ruth Knops, Louis T. van de Locht, Aniek O. de Graaf, Marion Massop, Sarah Sandmann, Martin Dugas, Marian J. Stevens-Kroef, Jaroslav Cermak, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Theo de Witte, Nicole M. A. Blijlevens, Petra Muus, Gerwin Huls, Bert A. van der Reijden, Seishi Ogawa, Joop H. Jansen   +22 more
doaj   +8 more sources

Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer [PDF]

Nature Communications
Prostate cancer is a highly heterogeneous disease, driven by genomic and transcriptional changes that impact disease progression and metastatic potential. The interplay between clonal evolution, transcriptional plasticity, and tumour microenvironment is,
Migle Mikutenaite, Evdoxia Karadoulama, Francesco Favero, Alessio Locallo, Francisco German Rodriguez Gonzalez, Daria Kiriy, Tina Keshavarzian, Kira Furlano, Markus Graefen, Robert G. Bristow, Clarissa Gerhäuser, Christoph Plass, Guido Sauter, Ronald Simon, Mathieu Lupien, Sarah Minner, Thorsten Schlomm, Joachim Weischenfeldt   +17 more
doaj   +2 more sources

Exploration of the clonal evolution and construction of the tumor clonal evolution rate as a prognostic indicator in metastatic breast cancer [PDF]

BMC Medicine
Background Tumor heterogeneity and clonal evolution are related to the treatment resistance and disease progression in metastatic breast cancer (MBC). However, the process of clonal evolution and their relationship to prognosis remain unclear. This study
Dan Lv, Bo Lan, Qihan Guo, Zongbi Yi, Haili Qian, Yanfang Guan, Xuenan Peng, Ting Chen, Fei Ma   +8 more
doaj   +2 more sources

Clonal evolution driven by superdriver mutations [PDF]

BMC Evolutionary Biology, 2020
Background Tumors are widely recognized to progress through clonal evolution by sequentially acquiring selectively advantageous genetic alterations that significantly contribute to tumorigenesis and thus are termned drivers.
Patrick Grossmann, Simona Cristea, Niko Beerenwinkel   +2 more
doaj   +4 more sources

Single-cell proteogenomic analysis of clonal evolution in PDX models of AML treated with IDH inhibitors [PDF]

Blood Neoplasia
: Clonal heterogeneity in acute myeloid leukemia (AML) can drive drug resistance because different clones may respond variably to treatments. Studying the evolution of these clones under the influence of therapeutic selective pressures is important for ...
Alex C. H. Liu, Severine Cathelin, Dhanoop Manikoth Ayyathan, Yitong Yang, Farzaneh Aboualizadeh, Amina Abow, Gurbaksh Basi, Lance Li, David L. Dai, Abdula Maher, Eric Grignano, Mohsen Hosseini, Vivian Wang, Troy Ketela, Brandon Nicolay, Dylan M. Marchione, Adriana E. Tron, Andrea Arruda, Mark D. Minden, Steven M. Chan   +19 more
doaj   +2 more sources

An inflammatory T-cell-stromal axis contributes to hematopoietic stem/progenitor cell failure and clonal evolution in human myelodysplastic syndrome [PDF]

Nature Communications
Myelodysplastic syndrome (MDS) is characterized by bone marrow failure, clonal evolution and leukemic progression, but the pathophysiologic processes driving these events remain incompletely understood.
Lanpeng Chen, Yujie Bian, Eline Pronk, Claire van Dijk, Tim V.D. van Tienhoven, Remco M. Hoogenboezem, Eric M. Bindels, Dennis Bosch, Sadaf Fazeli, Aniek O. de Graaf, Theresia M. Westers, Maksim Kholmatov, Judith B. Zaugg, Pedro L. Moura, Eva Hellström-Lindberg, Arjan A. van de Loosdrecht, Joop H. Jansen, Mathijs A. Sanders, Marc H.G.P. Raaijmakers   +18 more
doaj   +2 more sources

Hematopoietic Clonal Evolution Goes Spatial. [PDF]

Blood Cancer Discov
Summary:The spatial distribution of cells carrying clonal hematopoiesis mutations in the bone marrow and the potential role of interactions with the microenvironment are largely unknown. This study takes clonal evolution to the spatial level by describing a novel technique examining the spatial location of mutated clones in the bone marrow and the ...
Austin R, Aifantis I.
europepmc   +3 more sources

Clonal evolution: a landmark of MPN evolution

Frontiers in Hematology
Myeloproliferative Neoplasms comprise a heterogeneous group of diseases characterized over the past two decades by the acquisition of somatic mutations in hematopoietic stem cells, leading to a pre-leukemic state.
Nabih Maslah, Nabih Maslah, Stephane Giraudier, Stephane Giraudier, Bruno Cassinat, Bruno Cassinat, Jean-Jacques Kiladjian, Jean-Jacques Kiladjian   +7 more
doaj   +2 more sources

LinG3D: visualizing the spatio-temporal dynamics of clonal evolution [PDF]

BMC Bioinformatics
Background Cancers are spatially heterogenous, thus their clonal evolution, especially following anti-cancer treatments, depends on where the mutated cells are located within the tumor tissue.
Anjun Hu, Awino Maureiq E. Ojwang’, Kayode D. Olumoyin, Katarzyna A. Rejniak   +3 more
doaj   +2 more sources