Results 1 to 10 of about 41,259 (301)

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway [PDF]

Nature Communications, 2019
Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis ...
Sisi Chen, Qiang Wang, Hao Yu, Maegan L. Capitano, Sasidhar Vemula, Sarah C. Nabinger, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Zhuangzhuang Geng, Aidan Fahey, Danielle Henley, Stephen Z. Liu, Sergio Barajas, Wenjie Cai, Eric R. Wolf, Baskar Ramdas, Zhigang Cai, Hongyu Gao, Na Luo, Yang Sun, Terrence N. Wong, Daniel C. Link, Yunlong Liu, H. Scott Boswell, Lindsey D. Mayo, Gang Huang, Reuben Kapur, Mervin C. Yoder, Hal E. Broxmeyer, Zhonghua Gao, Yan Liu   +31 more
doaj   +3 more sources

Evolution of clonal hematopoiesis

Clinical and Translational Medicine, 2023
Contains fulltext : 300034.pdf (Publisher’s version ) (Open Access)
Isabelle A. van Zeventer, Aniek O. de Graaf, Joop H. Jansen, Gerwin Huls   +3 more
doaj   +5 more sources

Tumor-Infiltrating Clonal Hematopoiesis. [PDF]

N Engl J Med
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencies can be detected in tumors, a phenomenon we term tumor-infiltrating clonal hematopoiesis (TI-CH).
Pich O, Bernard E, Zagorulya M, Rowan A, Pospori C, Slama R, Huerga Encabo H, O'Sullivan J, Papazoglou D, Anastasiou P, Iliakis CS, Clark SA, Dijkstra KK, Barbè V, Bailey C, Stonestrom AJ, Enfield KSS, Green M, Brierley CK, Magness A, Pearce DR, Hynds RE, Zaidi R, Rane JK, Álvarez-Prado ÁF, Thol K, Scott R, Bola SK, Hoxha E, Harris SK, Peggs KS, Quezada SA, Hackshaw A, Zaccaria S, Joyce JA, Malanchi I, Berger MF, Jamal-Hanjani M, Wack A, Downward J, Grey W, Lo Celso C, Grönroos E, Rudin CM, Mead AJ, Bonnet D, Papaemmanuil E, Swanton C.   +47 more
europepmc   +5 more sources

[Correspondence] Clonal hematopoiesis and atherosclerosis [PDF]

New England Journal of Medicine, 2017
Jaiswal et al. report the results of four case–control studies that confirm a near doubling in the risk of coronary heart disease in patients with CHIP,1 a finding that was first reported in the Journal in 2014.2 The authors postulate that two mechanisms
Chaudry, Sabah, Chevassut, Timothy, Phillips, Rupert   +2 more
core   +5 more sources

Clonal hematopoiesis and atherosclerosis

The Journal of Clinical Investigation
Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic mutations in certain known leukemia driver genes give rise to clones of mutant cells
Ohad Oren, Aeron M. Small, Peter Libby
doaj   +3 more sources

Prospective characterization of clonal hematopoiesis and its clinical associations in elderly patients [PDF]

Scientific Reports
Clonal hematopoiesis (CH) is characterized by the expansion of hematopoietic stem cell clones carrying somatic mutations that confer a proliferative advantage, encompassing conditions such as Clonal Hematopoiesis of Indeterminate Potential (CHIP) and ...
Thaís B. Moyen, Victoria Tomaz, Luiz Gustavo F. Cortes, Susana Rosa, Fabio P. S. Santos, Nelson Hamerschlak, Renato D. Puga, Rodrigo D. S. Reis, Roberta C. Petroni, Caroline N. Silveira, Maria Fernanda P. Moretti, Maysa S. Cendoroglo, Paulo V. Campregher   +12 more
doaj   +2 more sources

Clonal Hematopoiesis and Thrombosis. [PDF]

Am J Hematol
ABSTRACTClonal hematopoiesis (CH) has been the focus of many research efforts in the last years and has emerged as a risk modifier for cardiovascular disease morbidity and mortality. While substantial evidence has accumulated regarding its impact on arterial system diseases, the connection with venous thrombosis has only recently been explored.
Englisch C, Ay C.
europepmc   +3 more sources

Clonal Hematopoiesis and Solid Cancers. [PDF]

Cancer Sci
ABSTRACTClonal hematopoiesis refers to the expansion of hematopoietic stem cells harboring somatic mutations, a phenomenon increasingly recognized in aging populations. This review highlights the emerging relationship between clonal hematopoiesis and solid cancers, focusing on the prevalence and impact of clonal hematopoiesis–associated mutations such ...
Nguyen YTM, Fujisawa M, Ishikawa S, Sakata-Yanagimoto M.   +3 more
europepmc   +4 more sources

Genetic Predisposition to Clonal Hematopoiesis

HemaSphere, 2023
Pedro M. Quiros, George S. Vassiliou
doaj   +4 more sources

Common in atherogenesis and carcinogenesis: clonal hematopoiesis

Российский кардиологический журнал, 2023
Clonal hematopoiesis is a common age-dependent state accompanied by the expansion of mutant hematopoietic stem cells as a result of somatic mutations and is associated with a high risk of hematopoietic neoplasms and cardiovascular diseases.
A. A. Sleptsov, M. S. Nazarenko, V. Р. Puzyrev   +2 more
doaj   +1 more source