Results 1 to 10 of about 143,820 (254)
Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life
Nature CommunicationsClonal hematopoiesis becomes increasingly common with age, but its cause is enigmatic because driver mutations are often absent. Serial observations infer weak selection indicating variants are acquired much earlier in life with unexplained initial ...
Jesse Kreger +3 more
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Protocol for monitoring clonal hematopoiesis in transgenic mouse models using multispectral imaging
STAR ProtocolsSummary: Clonal hematopoiesis involves the clonal expansion of hematopoietic cells, potentially progressing into hematological malignancies. Here, we present a protocol for the development and characterization of two mouse models designed to simulate ...
Priyanka Khanna +5 more
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Cells, 2022 Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate ...
Stefan Kuhnert +20 more
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Obesity-induced inflammation exacerbates clonal hematopoiesis
The Journal of Clinical Investigation, 2023 Characterized by the accumulation of somatic mutations in blood cell lineages, clonal hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the expansion of mutated hematopoietic stem and progenitor cells (HSC/Ps) that leads ...
Santhosh Kumar Pasupuleti +20 more
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Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms
Nature CommunicationsClonal hematopoiesis of indeterminate potential is the primary pathogenic risk factor for myeloid neoplasms, while heteroplasmy (mutations in a subset of cellular mitochondrial DNA) is another marker of clonal expansion associated with hematological ...
Yun Soo Hong +13 more
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Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics
Immunity & Ageing, 2022 Background Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular disease.
Md Mesbah Uddin +15 more
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Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment, and Therapy
CellsMyelodysplastic syndromes are clonal hematopoietic neoplasms in which ineffective hematopoiesis arises within the context of chronic inflammation and immune dysregulation.
Adele Bottaro +4 more
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The Journal of Clinical InvestigationAortic aneurysms are age-linked aortic dilations that progress silently and carry high mortality rates following rupture. Immune cells are recognized drivers of aneurysm pathogenesis.
Jun Yonekawa +16 more
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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
Nature Communications, 2018 Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.
Terrence N. Wong +21 more
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Loss of Y chromosome in Alzheimer’s patients co-occurs with somatic mutations beyond CHIP drivers
Life Science AllianceUnknown driver mutations are enriched in Alzheimer’s patients with Y chromosome loss, suggesting LOY-driven clonal myeloid expansion may contribute to distinct disease-associated mutational profiles. Loss of Y chromosome (LOY) and clonal hematopoiesis of
Edyta Rychlicka-Buniowska +19 more
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