Results 21 to 30 of about 143,820 (254)
Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis
Acta Pharmaceutica Sinica B, 2022 Aging-elevated DNMT3A R882H-driven clonal hematopoiesis (CH) is a risk factor for myeloid malignancies remission and overall survival. Although some studies were conducted to investigate this phenomenon, the exact mechanism is still under debate. In this
Min Liao +9 more
doaj +1 more source
Clonal hematopoiesis in cancer. [PDF]
, 2020 Clonal hematopoiesis is a common premalignant condition defined by the abnormal expansion of clonally derived hematopoietic stem cells carrying somatic mutations in leukemia-associated genes.
Bejar, Rafael, Park, Soo J
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Utility of plasma cell-free DNA for de novo detection and quantification of clonal hematopoiesis
Haematologica, 2021 Although cell-free DNA (cfDNA) tests have emerged as a potential non-invasive alternative to bone marrow biopsies for monitoring clonal hematopoiesis in hematologic diseases, whether commercial cfDNA assays can be implemented for the detection and ...
Fernanda Gutierrez-Rodrigues +10 more
doaj +1 more source
siddhartha-kar/clonal-hematopoiesis: clonal hematopoiesis paper code repository
, 2022 This is the repository accompanying the pre-print titled, "Genome-wide analyses of 200,453 individuals yields new insights into the causes and consequences of clonal hematopoiesis" (https://www.medrxiv.org/content/10.1101/2022.01.06.22268846v1)
Siddhartha Kar
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Clonal hematopoiesis and atherosclerotic cardiovascular disease: A primer. [PDF]
, 2023 Despite current standards of care, a considerable risk of atherosclerotic cardiovascular disease remains in both primary and secondary prevention. In this setting, clonal hematopoiesis driven by somatic mutations has recently emerged as a relatively ...
Fuster, Jose J. +3 more
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Clonal hematopoiesis and myeloid malignancies: clonal dynamics and clinical implications
, 2021 Purpose of review Clinical and experimental studies have uncovered relevant clinical implications of clonal hematopoiesis. However, the true magnitude of this process, clonal dynamics over time and mechanisms of progression into overt malignancy remain ...
Todisco, Gabriele +9 more
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Supplemental Fig. S1 from Clonal Hematopoiesis in Young Women Treated for Breast Cancer
, 2023 All Clonal Hematopoiesis in the ...
Christopher J. Gibson (15907642) +12 more
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Clonal hematopoiesis, aging and Alzheimer\u27s disease.
, 2023 Unexpectedly, new data show that clonal hematopoiesis is associated with protection from Alzheimer’s disease; it is imperative that future studies unravel the complex tissue– disease contexts in which clonal hematopoiesis arises and contributes to aging ...
Levine, Ross L +2 more
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Life, 2022 Hematopoietic stem cell aging, through the acquisition of somatic mutations, gives rise to clonal hematopoiesis (CH). While a high prevalence of CH has been described in otherwise healthy older adults, CH confers an increased risk of both hematologic and
Charles Gaulin +2 more
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Dissecting Clonal Hematopoiesis in Tissues of Classical Hodgkin Lymphoma Patients
, 2021 Clonal hematopoiesis predisposes to hematological malignancies. However, clonal hematopoiesis is understudied in classical Hodgkin lymphoma (cHL), a mature B-cell neoplasm exhibiting the most abundant microenvironment. We analyzed clonal hematopoiesis in
Andrea Marra +16 more
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