Results 41 to 50 of about 143,820 (254)

Clonal hematopoiesis as a pitfall in germline variant interpretation in the context of Mendelian disorders. [PDF]

, 2022
Clonal hematopoiesis due to somatic mutations in hematopoietic stem/progenitor cells is an age-related phenomenon and commonly observed when sequencing blood DNA in elderly individuals.
Götze, K.S., Gasser, T., Choukair, Daniela, Diehl-Schmid, Janine, Eckstein, G., Hoefele, J., Berutti, Riccardo, Graf, Elisabeth, Hecker, J.S., Krenn, M., Meitinger, Thomas, Krenn, Martin, Strom, Tim M., Goetze, Katharina S., Brunet, T., Brunet, Theresa, Diehl-Schmid, J., Hecker, Judith S., Graf, E., Deschauer, Marcus, Berutti, R., Dill, V., Dill, Veronika, Eckstein, Gertrud, Hoefele, Julia, Meitinger, T., Wagner, M., Wagner, Matias, Choukair, D., Strom, T.M., Andres, S., Gasser, Thomas, Deschauer, M., Andres, Stephanie, Julia Hoefele, Janine Diehl-Schmid, Riccardo Berutti, Gertrud Eckstein, Theresa Brunet, Elisabeth Graf, Judith S Hecker, Thomas Gasser, Matias Wagner, Veronika Dill, Martin Krenn, Katharina S Götze, Stephanie Andres, Marcus Deschauer, Tim M Strom, Thomas Meitinger, Daniela Choukair   +50 more
core   +1 more source

Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis

JCI Insight, 2022
Mosaic loss of chromosome Y (mLOY) in blood cells is one of the most frequent chromosome alterations in adult males. It is strongly associated with clonal hematopoiesis, hematopoietic malignancies, and other hematopoietic and nonhematopoietic diseases ...
Qi Zhang, Lei Zhao, Yi Yang, Shujun Li, Yu Liu, Chong Chen   +5 more
doaj   +1 more source

Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure

JACC: Basic to Translational Science, 2020
Heart failure is a common disease with poor prognosis that is associated with cardiac immune cell infiltration and dysregulated cytokine expression. Recently, the clonal expansion of hematopoietic cells with acquired (i.e., nonheritable) DNA mutations, a
Yoshimitsu Yura, MD, PhD, Soichi Sano, MD, PhD, Kenneth Walsh, PhD   +2 more
doaj   +1 more source

Clonal hematopoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in virally suppressed individuals with HIV

, 2021
The prevalence of clonal hematopoiesis mutations adjusted for age was increased and clone size was larger in people with HIV compared to uninfected controls.
Riksen, Niels P., de Voer, Richarda M., van de Wijer, Lisa, van den Munckhof, Inge C. L., Steehouwer, Marloes, Hoischen, Alexander, van der Ven, Andre J., van der Heijden, Wouter A., Vandekerckhove, Linos, Netea, Mihai G., van Deuren, Rosanne C., de Mast, Quirijn, Mast, Q. de, Wijer, L. van de, Munckhof, I.C.L. van den, Vandekerckhove, L., Netea, M.G., Steehouwer, M., Heijden, W.A. van der, Hoischen, A., Voer, R.M. de, Riksen, N.P., Deuren, R.C. van, Ven, A.J. van der, Quirijn de Mast, Richarda M de Voer, Marloes Steehouwer, Alexander Hoischen, Mihai G Netea, Linos Vandekerckhove, Andre J van der Ven, Rosanne C van Deuren, Wouter A van der Heijden, Lisa van de Wijer, Niels P Riksen, Inge C L van den Munckhof   +35 more
core   +1 more source

Hidden agendas: Clonal hematopoiesis accelerates heart failure

, 2018
Clonal hematopoiesis driven by TET2 deficiency accelerates post-infarct remodeling and heart failure through the NLRP3 inflammasome and IL-1β production.
Kory Lavine
core   +1 more source

ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing

, 2021
Clonal hematopoiesis results from somatic mutations in cancer driver genes in hematopoietic stem cells. We sought to identify novel drivers of clonal expansion using an unbiased analysis of sequencing data from 84,683 persons and identified common ...
Carr, Steven A, McConkey, Marie, Tanenbaum, Benjamin, Stanclift, Caroline, Nilsson, Björn, Miller, Mendy, Barbera, Alex, Lage, Kasper, Anand, Shankara, Tarun, Akansha, Schenone, Monica, Malcovati, Luca, Loos, Ruth, Hoppe, Emma R, Creignou, Maria, Castellano, Cecilia A, Psaty, Bruce M, Malolepsza, Edyta, Niroula, Abhishek, Neuberg, Donna S, Todisco, Gabriele, Stewart, Chip, Bick, Alexander G, Papaemmanuil, Elli, Lek, Monkol, Weinstock, Joshua S, Hellstrom-Lindberg, Eva, Gallì, Anna, Jaiswal, Siddhartha, Leventhal, Matthew, Dunford, Andrew, Desai, Pinkal, Wood, Timothy, Bradley, Robert K, Cho, Michael H, Ebert, Benjamin L, MacArthur, Daniel G, Bernard, Elsa, Getz, Gad, Beauchamp, Ellen M, Wong, Waihay, Johnson, Andrew D, Taylor-Weiner, Amaro, McConkey, M, Castellano, CA, Bernard, E, Hoppe, ER, Galli, A, Creignou, M,, Todisco, G, Leventhal, M, Tarun, A, Beauchamp, EM, Björn Nilsson, Eva Hellstrom-Lindberg, Bruce M. Psaty, Chip Stewart, Matthew Leventhal, null null, Gabriele Todisco, Kasper Lage, Steven A. Carr, Benjamin L. Ebert, Marie McConkey, Waihay Wong, Shankara Anand, Andrew Dunford, Mendy Miller, Donna S. Neuberg, Alex Barbera, Luca Malcovati, Maria Creignou, Anna Gallì, Caroline Stanclift, Joshua S. Weinstock, Timothy Wood, Gad Getz, Benjamin Tanenbaum, Pinkal Desai, Michael H. Cho, Siddhartha Jaiswal, Edyta Malolepsza, Elli Papaemmanuil, Ellen M. Beauchamp, Amaro Taylor-Weiner, Ruth Loos, Alexander G. Bick, Daniel G. MacArthur, Andrew D. Johnson, Monkol Lek, Akansha Tarun, Elsa Bernard, Monica Schenone, Emma R. Hoppe, Cecilia A. Castellano, Abhishek Niroula, Robert K. Bradley   +96 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

CSF3R T618I mutant myelodysplastic/myeloproliferative neoplasm in the elderly: An age-related disease with unfavorable prognosis

Leukemia Research Reports, 2022
We reported two MDS/MPN-U and one CMML patients with CSF3R T618I mutation. There were two males and one female, with a median age of 84 years. Three patients presented with leukocytosis and anemia, two with thrombocytopenia, and one with monocytosis.
Xinmin Zhang, Cristina Ghiuzeli, Erin Jou, Peihong Hsu, Jonathan Kolitz, Judith P Brody   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source