Results 41 to 50 of about 41,259 (301)

Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis

JCI Insight, 2022
Mosaic loss of chromosome Y (mLOY) in blood cells is one of the most frequent chromosome alterations in adult males. It is strongly associated with clonal hematopoiesis, hematopoietic malignancies, and other hematopoietic and nonhematopoietic diseases ...
Qi Zhang, Lei Zhao, Yi Yang, Shujun Li, Yu Liu, Chong Chen   +5 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential [PDF]

Deutsches Ärzteblatt international, 2016
Patients with cytopenia are increasingly undergoing molecular genetic tests of periperal blood or bone marrow for diagnostic purposes. These tests can detect genetic mutations that do not have any morphological correlate in hematologic neoplasia such as myelo - dysplastic syndrome (MDS). A new entity was recently defined to lessen the risk of incorrect
Michael, Heuser, Felicitas, Thol, Arnold, Ganser   +2 more
openaire   +2 more sources

A Vicious Circle Between Periodontitis And Clonal Hematopoiesis

International Dental Journal
Aim or purpose: Elucidating the molecular mechanisms underlying the bidirectional regulation between DNMT3A mutation-driven clonal hematopoiesis and periodontitis.
Qiao Yuan, Min Liao
doaj   +1 more source

Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD

Cells, 2022
Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate ...
Stefan Kuhnert, Siavash Mansouri, Michael A. Rieger, Rajkumar Savai, Edibe Avci, Gabriela Díaz-Piña, Manju Padmasekar, Mario Looso, Stefan Hadzic, Till Acker, Stephan Klatt, Jochen Wilhelm, Ingrid Fleming, Natascha Sommer, Norbert Weissmann, Claus Vogelmeier, Robert Bals, Andreas Zeiher, Stefanie Dimmeler, Werner Seeger, Soni S. Pullamsetti   +20 more
doaj   +1 more source

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

, 2014
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique, De Mulder, Katrien, Kerre, Tessa, Lambrecht, Bart, Leclercq, Georges, Menten, Björn, Philippé, Jan, Taghon, Tom, Van Caeneghem, Yasmine, Van Roy, Nadine, Vandekerckhove, Bart, Vanhee, Stijn, Velghe, Imke, Verstichel, Greet   +13 more
core   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Clonal Analysis of Hematopoiesis-Supporting Activity of Human Mesenchymal Stem Cells in Association with Jagged1 Expression and Osteogenic Potential

Cell Transplantation, 2008
Human mesenchymal stem cells (hMSCs) are promising feeder cells for expanding hematopoietic stem cells (HSCs), but their potential is heterogeneous.
Satoshi Fujita, Junya Toguchida, Yutaka Morita, Hiroo Iwata Ph.D.   +3 more
doaj   +1 more source

Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics

Immunity & Ageing, 2022
Background Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular disease.
Md Mesbah Uddin, Ying Zhou, Alexander G. Bick, Bala Bharathi Burugula, Siddhartha Jaiswal, Pinkal Desai, Michael C. Honigberg, Shelly-Ann Love, Ana Barac, Kathleen M. Hayden, JoAnn E. Manson, Eric A. Whitsel, Charles Kooperberg, Pradeep Natarajan, Alexander P. Reiner, Jacob O. Kitzman   +15 more
doaj   +1 more source

Clonal Hematopoiesis and Premalignant Diseases [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
Clonal hematopoiesis (CH) arises when mutations in the hematopoietic system confer a fitness advantage to specific clones, thereby favoring their disproportionate growth. The presence of CH increases with age and environmental exposures such as cytotoxic chemotherapy or radiotherapy.
Justin, Kaner, Pinkal, Desai, Nuria, Mencia-Trinchant, Monica L, Guzman, Gail J, Roboz, Duane C, Hassane   +5 more
openaire   +2 more sources