Results 31 to 40 of about 143,820 (254)
Supplemental Fig. S2 from Clonal Hematopoiesis in Young Women Treated for Breast Cancer
, 2023 Associations between Clonal Hematopoiesis (CH) and Survival in the ...
Christopher J. Gibson (15907642) +12 more
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Aging, hematopoiesis, and the myelodysplastic syndromes
Blood Advances, 2017 : The aging hematopoietic system undergoes numerous changes, including reduced production of red blood cells and lymphocytes as well as a relative increase in the production of myeloid cells. Emerging evidence indicates that many of these changes are due
Stephen S. Chung, Christopher Y. Park
doaj +1 more source
Somatic mutations and clonal hematopoiesis in congenital neutropenia [PDF]
, 2018 Key PointsHematopoietic stem/progenitor mutation burden is not increased in SCN. Clonal hematopoiesis due to mutations of TP53 is present in the majority of patients with SDS.
Jun Xia +20 more
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Clonal hematopoiesis and clinical outcomes
, 2020 This study is a systematic review of existing literature to summarize and, if appropriate, meta-analyze, studies reporting on the association of the presence of clonal hematopoiesis mutations and clinical ...
Kevin Nead
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Cell Reports, 2019 Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is caused by recurrent somatic mutations leading to clonal blood cell expansion. However, direct evidence of the fitness of CHIP-mutated human hematopoietic stem cells (HSCs) in blood ...
Christina A. Ortmann +20 more
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The evolutionary dynamics and fitness landscape of clonal hematopoiesis
, 2020 Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance remains largely unknown. Blood sequencing data from ~50,000 individuals
Young, Andrew L. +7 more
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Clonal Hematopoiesis and Its Functional Implications in MDS/AML
, 2023 Clonal hematopoiesis (CH) is now a specifically recognized as a precursor myeloid neoplasm and comprised clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS).
Singh, Gill Harinder Harry
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Why Single-Cell Sequencing Has Promise in MDS
Frontiers in Oncology, 2021 Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by ineffective hematopoiesis. The risk of MDS is associated with aging and the accumulation of somatic mutations in hematopoietic stem cells and progenitors (HSPC). While
Xuan Zhang +3 more
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A Vicious Circle Between Periodontitis And Clonal Hematopoiesis
International Dental JournalAim or purpose: Elucidating the molecular mechanisms underlying the bidirectional regulation between DNMT3A mutation-driven clonal hematopoiesis and periodontitis.
Qiao Yuan, Min Liao
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, 2021 Supplementary Figures show: i) Fig. S1: Microdissection of HRS cells and reactive lymphocytes from the cHL tissue; ii) Fig. S2: Tissue involvement by clonal hematopoiesis (in cHL Case 2; iii) Fig.S3: T-cell receptor gamma gene rearrangement analysis in ...
Luisa Tasselli (15127057) +16 more
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