Results 31 to 40 of about 41,259 (301)

Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. [PDF]

, 2018
Enhancers for embryonic stem (ES) cell-expressed genes and lineage-determining factors are characterized by conventional marks of enhancer activation in ES cells1-3, but it remains unclear whether enhancers destined to regulate cell-type-restricted ...
Destici, Eugin, Friedman, Meyer, Kim, Hong Sook, Ma, Qi, Ma, Wubin, Merkurjev, Daria, Ohgi, Kenneth, Rosenfeld, Michael G, Skowronska-Krawczyk, Dorota, Suter, Tom, Tan, Yuliang   +10 more
core   +2 more sources

Age-related clonal hematopoiesis [PDF]

Blood, 2018
Abstract Age-related alterations in the human blood system occur in B cells, T cells, cells of the innate system, as well as hematopoietic stem and progenitor cells (HSPCs). Interestingly, age-related, reduced genetic diversity can be identified at the stem cell level and also independently in B cells and T cells.
openaire   +2 more sources

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation

Cell Reports, 2019
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is caused by recurrent somatic mutations leading to clonal blood cell expansion. However, direct evidence of the fitness of CHIP-mutated human hematopoietic stem cells (HSCs) in blood ...
Christina A. Ortmann, Lena Dorsheimer, Khalil Abou-El-Ardat, Jennifer Hoffrichter, Birgit Assmus, Halvard Bonig, Anica Scholz, Heike Pfeifer, Hans Martin, Tobias Schmid, Bernhard Brüne, Sebastian Scheich, Björn Steffen, Julia Riemann, Stella Hermann, Alexandra Dukat, Gesine Bug, Christian H. Brandts, Sebastian Wagner, Hubert Serve, Michael A. Rieger   +20 more
doaj   +1 more source

CSF3R T618I mutant myelodysplastic/myeloproliferative neoplasm in the elderly: An age-related disease with unfavorable prognosis

Leukemia Research Reports, 2022
We reported two MDS/MPN-U and one CMML patients with CSF3R T618I mutation. There were two males and one female, with a median age of 84 years. Three patients presented with leukocytosis and anemia, two with thrombocytopenia, and one with monocytosis.
Xinmin Zhang, Cristina Ghiuzeli, Erin Jou, Peihong Hsu, Jonathan Kolitz, Judith P Brody   +5 more
doaj   +1 more source

Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques. [PDF]

, 2015
BACKGROUND:How a potentially diverse population of hematopoietic stem cells (HSCs) differentiates and proliferates to supply more than 10(11) mature blood cells every day in humans remains a key biological question.
Chen, Irvin SY, Chou, Tom, Goyal, Sidhartha, Kim, Sanggu   +3 more
core   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

Mesenchymal Differentiation and Organ Distribution of Established Human Stromal Cell Lines in NOD/SCID Mice [PDF]

, 2001
Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support
Huss, Ralf, Meissner, Petra, Moosmann, Sabine, Sagebiel, Sabine, Thalmeier, Karin, Wiest, Irmgard   +5 more
core   +1 more source

Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure

JACC: Basic to Translational Science, 2020
Heart failure is a common disease with poor prognosis that is associated with cardiac immune cell infiltration and dysregulated cytokine expression. Recently, the clonal expansion of hematopoietic cells with acquired (i.e., nonheritable) DNA mutations, a
Yoshimitsu Yura, MD, PhD, Soichi Sano, MD, PhD, Kenneth Walsh, PhD   +2 more
doaj   +1 more source

Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]

, 2004
Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Gottgens, Berthold, Heil, Matthias, Huss, Ralf, Kinston, Sarah, Moosmann, Sabine, Sagebiel, Sabine, Seliger, Christian, Ziegelhoeffer, Tibor   +7 more
core   +1 more source

Coronary atherosclerosis scoring with semiquantitative CCTA risk scores for prediction of major adverse cardiac events: Propensity score-based analysis of diabetic and non-diabetic patients. [PDF]

, 2020
AIMS:We aimed to compare semiquantitative coronary computed tomography angiography (CCTA) risk scores - which score presence, extent, composition, stenosis and/or location of coronary artery disease (CAD) - and their prognostic value between patients ...
Achenbach, Stephan, Al-Mallah, Mouaz H, Andreini, Daniele, Bax, Jeroen J, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo C, de Araújo Gonçalves, Pedro, DeLago, Augustin, Dimitriu-Leen, Aukelien C, Feuchtner, Gudrun, Gransar, Heidi, Hadamitzky, Martin, Hausleiter, Joerg, Jones, Erica C, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon A, Lin, Fay Y, Lu, Yao, Maffei, Erica, Marques, Hugo, Min, James K, Peña, Jessica M, Pontone, Gianluca, Raff, Gilbert L, Rubinshtein, Ronen, Scholte, Arthur JHA, Shaw, Leslee J, Smit, Jeff M, van den Hoogen, Inge J, van Rosendael, Alexander R, Villines, Todd C   +37 more
core   +1 more source