Clonal hematopoiesis of indeterminate potential and cardiovascular diseases: A review [PDF]
Indian Heart JournalCardiovascular disease (CVD) is a major driver of mortality and declining health worldwide. Cardiovascular diseases (CVD) is the most common cause of morbidity and mortality globally. Although dyslipidemia, smoking, diabetes, hypertension and obesity are
Nagendra Boopathy Senguttuvan +5 more
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Clonal Hematopoiesis of Indeterminate Potential From a Heart Failure Specialist's Point of View [PDF]
Journal of the American Heart Association, 2023 Clonal hematopoiesis of indeterminate potential (CHIP) is a common bone marrow abnormality induced by age‐related DNA mutations, which give rise to proinflammatory immune cells. These immune cells exacerbate atherosclerotic cardiovascular disease and may
Job A J Verdonschot +2 more
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CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC
Mediterranean Journal of Hematology and Infectious Diseases, 2022 Hematopoietic stem cells (HSCs) ensure the coordinated and balanced production of all hematopoietic cell types throughout life. Aging is associated with a gradual decline of the self-renewal and regenerative potential of HSCs and with the development of
Ugo Testa +2 more
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Risk factors of clonal hematopoiesis of indeterminate potential [PDF]
Clinical MedicineBackground: Accumulating evidence demonstrates associations between clonal hematopoiesis of indeterminate potential (CHIP) and increased risks of haematological and non-haematological health outcomes.
Qiaoxue Liu +6 more
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Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies
healthbook TIMES. Oncology Hematology, 2021 Clonal hematopoiesis of indeterminate potential (CHIP) is a condition characterized by accumulation of one or several somatic mutations in hematopoietic stem cells in the bone marrow.
Adrian Schmidt
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Clonal Hematopoiesis of Indeterminate Potential in Cardiovascular Disease: Gene-Specific Mechanisms and Therapeutic Implications [PDF]
International Journal of General MedicineXuejiao Zhang,1 Hongguang Zhang,2 Jia Fu,2 Shuo Feng,2 Ying Wang31Department of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of China; 2Department of Cardiology, The First Hospital of China ...
Zhang X, Zhang H, Fu J, Feng S, Wang Y
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Clonal hematopoiesis of indeterminate potential and cardiovascular disease: mechanistic insights, clinical implications, and the dawn of precision cardio-hematology [PDF]
Frontiers in Cardiovascular MedicineClonal hematopoiesis of indeterminate potential (CHIP) has substantially advanced our understanding of cardiovascular pathogenesis by demonstrating how somatic mutations in hematopoietic stem cells amplify the bone marrow–heart axis to accelerate ...
Hong Wu, Xinyi Meng, Long Li, Chao Zhang
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Clonal hematopoiesis of indeterminate potential and risk of autoimmune thyroid disease [PDF]
BMC MedicineBackground Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disease, often remaining asymptomatic until the thyroid is significantly affected. Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to drive
Xue Zhang +6 more
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Common in atherogenesis and carcinogenesis: clonal hematopoiesis
Российский кардиологический журнал, 2023 Clonal hematopoiesis is a common age-dependent state accompanied by the expansion of mutant hematopoietic stem cells as a result of somatic mutations and is associated with a high risk of hematopoietic neoplasms and cardiovascular diseases.
A. A. Sleptsov +2 more
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A study of elective genome sequencing and pharmacogenetic testing in an unselected population
Molecular Genetics & Genomic Medicine, 2021 Background Genome sequencing (GS) of individuals without a medical indication, known as elective GS, is now available at a number of centers around the United States.
Meagan Cochran +9 more
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