Results 1 to 10 of about 6,041 (204)

Clonal hematopoiesis of indeterminate potential and cardiovascular diseases: A review [PDF]

Indian Heart Journal
Cardiovascular disease (CVD) is a major driver of mortality and declining health worldwide. Cardiovascular diseases (CVD) is the most common cause of morbidity and mortality globally. Although dyslipidemia, smoking, diabetes, hypertension and obesity are
Nagendra Boopathy Senguttuvan, Vinodhini Subramanian, Muralidharan TR, Kavitha Sankaranarayanan, Vettriselvi Venkatesan, Thanikachalam Sadagopan   +5 more
doaj   +4 more sources

Clonal hematopoiesis of indeterminate potential and heart failure [PDF]

Российский кардиологический журнал
Modern studies demonstrate that clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for the development and prognosis of heart failure (HF) of various origin. The pathophysiology and consequences of CHIP are gene-specific.
E. A. Lyasnikova, L. Yu Ivanchenko, S. N. Kozlova, M. Yu. SITNIKOVA, A. A. Kostareva, E. V. Shlyakhto   +5 more
doaj   +4 more sources

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway [PDF]

Nature Communications, 2019
Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis ...
Sisi Chen, Qiang Wang, Hao Yu, Maegan L. Capitano, Sasidhar Vemula, Sarah C. Nabinger, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Zhuangzhuang Geng, Aidan Fahey, Danielle Henley, Stephen Z. Liu, Sergio Barajas, Wenjie Cai, Eric R. Wolf, Baskar Ramdas, Zhigang Cai, Hongyu Gao, Na Luo, Yang Sun, Terrence N. Wong, Daniel C. Link, Yunlong Liu, H. Scott Boswell, Lindsey D. Mayo, Gang Huang, Reuben Kapur, Mervin C. Yoder, Hal E. Broxmeyer, Zhonghua Gao, Yan Liu   +31 more
doaj   +6 more sources

Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV [PDF]

Scientific Reports, 2022
People living with human immunodeficiency virus (PLWH) have significantly increased risk for cardiovascular disease in part due to inflammation and immune dysregulation.
Alexander G. Bick, Konstantin Popadin, Christian W. Thorball, Md Mesbah Uddin, Markella V. Zanni, Bing Yu, Matthias Cavassini, Andri Rauch, Philip Tarr, Patrick Schmid, Enos Bernasconi, Huldrych F. Günthard, Peter Libby, Eric Boerwinkle, Paul J. McLaren, Christie M. Ballantyne, Steven Grinspoon, Pradeep Natarajan, Jacques Fellay, the Swiss HIV Cohort Study   +19 more
doaj   +2 more sources

Clonal hematopoiesis of indeterminate potential and cardiovascular disease: mechanistic insights, clinical implications, and the dawn of precision cardio-hematology [PDF]

Frontiers in Cardiovascular Medicine
Clonal hematopoiesis of indeterminate potential (CHIP) has substantially advanced our understanding of cardiovascular pathogenesis by demonstrating how somatic mutations in hematopoietic stem cells amplify the bone marrow–heart axis to accelerate ...
Hong Wu, Xinyi Meng, Long Li, Chao Zhang
doaj   +2 more sources

Clonal hematopoiesis of indeterminate potential and risk of autoimmune thyroid disease [PDF]

BMC Medicine
Background Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disease, often remaining asymptomatic until the thyroid is significantly affected. Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to drive
Xue Zhang, Yuqing Wang, Huiwen Xue, Yingsuo Zhao, Mingcheng Liu, Hui Wei, Qianwei Liu   +6 more
doaj   +2 more sources

Cancer patients with clonal hematopoiesis die from primary malignancy or comorbidities despite higher rates of transformation to myeloid neoplasms [PDF]

Cancer Medicine
Background The occurrence of somatic mutations in patients with no evidence of hematological disorders is called clonal hematopoiesis (CH). CH, whose subtypes include CH of indeterminate potential and clonal cytopenia of undetermined significance, has ...
Kelly S. Chien, Faustine Ong, Kunhwa Kim, Ziyi Li, Rashmi Kanagal‐Shamanna, Courtney D. DiNardo, Koichi Takahashi, Guillermo Montalban‐Bravo, Danielle Hammond, Koji Sasaki, Sherry A. Pierce, Hagop M. Kantarjian, Guillermo Garcia‐Manero   +12 more
doaj   +3 more sources

Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential: Results From the Women's Health Initiative

Journal of the American Heart Association, 2021
Background Presence of clonal hematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of atherosclerotic cardiovascular disease, cancer, and mortality. The relationship between a healthy lifestyle and CHIP is unknown. Methods and
Bernhard Haring, Deirdre K Tobias, Jeffrey S Berger   +2 more
exaly   +3 more sources

Clonal Hematopoiesis of Indeterminate Potential From a Heart Failure Specialist's Point of View

Journal of the American Heart Association, 2023
Clonal hematopoiesis of indeterminate potential (CHIP) is a common bone marrow abnormality induced by age‐related DNA mutations, which give rise to proinflammatory immune cells. These immune cells exacerbate atherosclerotic cardiovascular disease and may
Maurits A Sikking, Sophie L V M Stroeks, Olivia J Waring   +2 more
exaly   +3 more sources

Determinants of mosaic chromosomal alteration fitness [PDF]

Nature Communications
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural ...
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick   +43 more
doaj   +3 more sources