Results 31 to 40 of about 173,423,441 (192)

siddhartha-kar/clonal-hematopoiesis: clonal hematopoiesis paper code repository

, 2022
This is the repository accompanying the pre-print titled, "Genome-wide analyses of 200,453 individuals yields new insights into the causes and consequences of clonal hematopoiesis" (https://www.medrxiv.org/content/10.1101/2022.01.06.22268846v1)
Siddhartha Kar
core   +1 more source

Exploring the associations between clonal hematopoiesis of indeterminate potential, myeloid malignancy, and atherosclerosis

, 2022
Outgrowth of a mutated hematopoietic stem/progenitor clone and its descendants, also known as clonal hematopoiesis, has long been considered as either a potential forerunner to hematologic malignancy or as a clinically silent phase in leukemia that ...
Juan Bautista Menendez-Gonzalez, Neil P. Rodrigues, Menendez-Gonzalez, Juan Bautista, Rodrigues, Neil P.   +3 more
core   +1 more source

Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic Neoplasm

Life, 2022
Hematopoietic stem cell aging, through the acquisition of somatic mutations, gives rise to clonal hematopoiesis (CH). While a high prevalence of CH has been described in otherwise healthy older adults, CH confers an increased risk of both hematologic and
Charles Gaulin, Katalin Kelemen, Cecilia Arana Yi   +2 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential and Progression of CKD. [PDF]

J Am Soc Nephrol
Key Points Non- DNMT3A clonal hematopoiesis of indeterminate potential was associated with CKD progression in a meta-analysis of 5654 individuals with ...
Vlasschaert C, Pan Y, Chen J, Akwo E, Rao V, Hixson JE, Chong M, Uddin MM, Yu Z, Jiang M, Peng F, Cao S, Wang Y, Kim DK, Hung AM, He J, Tamura MK, Cohen DL, He J, Li C, Bhat Z, Rao P, Xie D, Bick AG, Kestenbaum B, Paré G, Rauh MJ, Levin A, Natarajan P, Lash JP, Zhang MZ, Harris RC, Robinson-Cohen C, Lanktree MB, Kelly TN, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.   +35 more
europepmc   +3 more sources

Patient perspectives on testing for clonal hematopoiesis of indeterminate potential

Blood Advances, 2022
Abstract Clonal hematopoiesis of indeterminate potential (CHIP), an emerging biomarker for personalized risk-directed interventions, is increased in cancer survivors. However, little is known about patient preferences for CHIP testing. We surveyed participants in a prospective cohort study of young women with breast cancer (BC).
Tal Sella, Geoffrey G. Fell, Peter G. Miller, Christopher J. Gibson, Shoshana M. Rosenberg, Craig Snow, Daniel G. Stover, Kathryn J. Ruddy, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ellen Warner, Elizabeth Frank, Donna S. Neuberg, Benjamin L. Ebert, Ann H. Partridge   +16 more
openaire   +2 more sources

Clonal Hematopoiesis and Its Functional Implications in MDS/AML

, 2023
Clonal hematopoiesis (CH) is now a specifically recognized as a precursor myeloid neoplasm and comprised clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS).
Singh, Gill Harinder Harry
core   +1 more source

Clonal Hematopoiesis of Indeterminate Potential in Crohn's Disease and Ulcerative Colitis. [PDF]

Inflamm Bowel Dis
Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of somatic mutations in myeloid and lymphoid malignancy genes in the blood cells of individuals without a hematologic malignancy.
Esai Selvan M, Nathan DI, Guisado D, Collatuzzo G, Iruvanti S, Boffetta P, Mascarenhas J, Hoffman R, Cohen LJ, Marcellino BK, Gümüş ZH.   +10 more
europepmc   +5 more sources

Clonal hematopoiesis of indeterminate potential and incidence of venous thromboembolism in older adults [PDF]

Journal of Thrombosis and Haemostasis
Ang Li, Seyedmohammad Saadatagah
exaly   +2 more sources

Clinical consequences of clonal hematopoiesis of indeterminate potential [PDF]

Blood Advances, 2018
Abstract Clonally restricted hematopoiesis is a common aging-associated biological state that predisposes to subsequent development of a hematological malignancy or cardiovascular death. Clonal expansion driven by leukemia-associated somatic mutations, such as DNMT3A, ASXL1, or TET2, is best characterized, but oligoclonality can also ...
openaire   +4 more sources

Cellular heterogeneity and clonal hematopoiesis of immune system cells in atherosclerosis

Российский кардиологический журнал, 2022
Recent studies in single cell RNA sequencing have improved understanding of the structure of the immune cell subpopulation in atherosclerosis. With the help of novel technologies, new subpopulations of immune cells involved in atherosclerosis have been ...
A. A. Sleptsov
doaj   +1 more source