Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies
healthbook TIMES. Oncology Hematology, 2021 Clonal hematopoiesis of indeterminate potential (CHIP) is a condition characterized by accumulation of one or several somatic mutations in hematopoietic stem cells in the bone marrow.
Adrian Schmidt
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Life, 2022 Hematopoietic stem cell aging, through the acquisition of somatic mutations, gives rise to clonal hematopoiesis (CH). While a high prevalence of CH has been described in otherwise healthy older adults, CH confers an increased risk of both hematologic and
Charles Gaulin +2 more
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Clonal Hematopoiesis of Indeterminate Potential in Crohn's Disease and Ulcerative Colitis. [PDF]
Inflamm Bowel DisAbstract Background Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of somatic mutations in myeloid and lymphoid malignancy genes in the blood cells of individuals without a hematologic malignancy.
Esai Selvan M +10 more
europepmc +5 more sources
Rare lymphoid malignancies of the breast: a report of two cases illustrating potential diagnostic pitfalls [PDF]
, 2009 Breast involvement by lymphoma is uncommon and poses challenges in diagnosis. Lymphomas may clinically, radiologically, and morphologically mimic both benign and neoplastic conditions.
Farkash, Evan Andrew +6 more
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A study of elective genome sequencing and pharmacogenetic testing in an unselected population
Molecular Genetics & Genomic Medicine, 2021 Background Genome sequencing (GS) of individuals without a medical indication, known as elective GS, is now available at a number of centers around the United States.
Meagan Cochran +9 more
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Donor engrafted clonal hematopoiesis of indeterminate potential in allogeneic hematopoietic stem cell transplantation [PDF]
, 2023 Introduction: Clonal hematopoiesis of indeterminate (CHIP) describes the presence of hemato-logic cancer-associated somatic mutations in at least 4% of peripheral nucleated blood cells in the absence of further criteria for hematological malignancies ...
Chan, Willy
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Cellular heterogeneity and clonal hematopoiesis of immune system cells in atherosclerosis
Российский кардиологический журнал, 2022 Recent studies in single cell RNA sequencing have improved understanding of the structure of the immune cell subpopulation in atherosclerosis. With the help of novel technologies, new subpopulations of immune cells involved in atherosclerosis have been ...
A. A. Sleptsov
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Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk [PDF]
, 2022 Purpose of Review Clonal hematopoiesis of indeterminate potential (CHIP) has been identifed as a novel cardiovascular risk factor. Here we review the relationship of lifestyle and environmental risk factors predisposing to somatic mutations and CHIP ...
Haring, Bernhard +2 more
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Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia [PDF]
, 2017 Background The majority of individuals with acute myeloid leukemia (AML) respond to initial chemotherapy and achieve a complete remission, yet only a minority experience long-term survival because a large proportion of patients eventually relapse with ...
Hubert Hackl +2 more
core +3 more sources
Patient perspectives on testing for clonal hematopoiesis of indeterminate potential
Blood Advances, 2022 Abstract Clonal hematopoiesis of indeterminate potential (CHIP), an emerging biomarker for personalized risk-directed interventions, is increased in cancer survivors. However, little is known about patient preferences for CHIP testing. We surveyed participants in a prospective cohort study of young women with breast cancer (BC).
Tal Sella +16 more
openaire +2 more sources