Results 11 to 20 of about 173,423,441 (192)
Clonal hematopoiesis of indeterminate potential and heart failure [PDF]
Российский кардиологический журналModern studies demonstrate that clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for the development and prognosis of heart failure (HF) of various origin. The pathophysiology and consequences of CHIP are gene-specific.
E. A. Lyasnikova +5 more
doaj +3 more sources
A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology [PDF]
Cancers, 2022 Clonal hematopoiesis of indeterminate potential can be defined as genetic mutations that correlate in hematologic neoplasia such as myelodysplastic syndrome. Patients with cytopenia increasingly undergo molecular genetic tests of peripheral blood or bone marrow for diagnostic purposes.
Maroun Bou Zerdan +7 more
openaire +3 more sources
Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Disease [PDF]
Current Oncology Reports, 2020 The purpose of this review article is to summarize the preclinical and clinical evidence supporting the notion of clonal hematopoiesis of indeterminate potential (CHIP), highlight current knowledge gap, and provide future directions.Epidemiological studies show that advanced age is a major risk factor for the development of cardiovascular disease (CVD)
Kumar, Preetham +3 more
core +6 more sources
p53 involvement in clonal hematopoiesis of indeterminate potential [PDF]
Current Opinion in Hematology, 2019 Purpose of review Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and occurs when a single mutant hematopoietic stem cell (HSC) contributes to a significant clonal proportion of mature blood lineages.
Chen, Sisi, Liu, Yan
openaire +3 more sources
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway
Nature Communications, 2019 Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis ...
Sisi Chen +31 more
doaj +2 more sources
Clonal hematopoiesis of indeterminate potential and atrial fibrillation
Heart RhythmAtrial fibrillation (AF) is the most common sustained arrhythmia. Clonal hematopoiesis of indeterminate potential, characterized by the clonal expansion of hematopoietic stem cells owing to acquired mutations without hematologic malignancies, has emerged as a potential risk factor for AF. This narrative review summarizes the shared risk factors between
Jie Liu +6 more
core +5 more sources
Telomere Attrition and Clonal Hematopoiesis of Indeterminate Potential in Cardiovascular Disease [PDF]
International Journal of Molecular Sciences, 2021 Clinical evidence suggests that conventional cardiovascular disease (CVD) risk factors cannot explain all CVD incidences. Recent studies have shown that telomere attrition, clonal hematopoiesis of indeterminate potential (CHIP), and atherosclerosis (telomere–CHIP–atherosclerosis, TCA) evolve to play a crucial role in CVD.
Yi-Chun Huang, Chao-Yung Wang
core +4 more sources
Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases [PDF]
Journal of Internal MedicineAbstractBackgroundClonal hematopoiesis of indeterminate potential (CHIP), characterized by the age‐related expansion of blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate the association between CHIP and established autoimmune diseases.MethodsWe analyzed baseline data from 456,692 UK Biobank ...
Ningjian Wang, Xiao Tan, Hanzhang Wu
exaly +5 more sources
Genetics of smoking and risk of clonal hematopoiesis
Scientific Reports, 2022 Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing expanded somatic mutations have been linked to both oncologic and non-oncologic clinical ...
Michael G. Levin +8 more
doaj +2 more sources
Genes and Diseases, 2018 At least 10% of the elderly population above the age of 70 carry a condition termed clonal hematopoiesis indeterminate potential (CHIP) due to oligoclonal expansion of mutated hematopoietic stem cells.
Fei Li +3 more
doaj +2 more sources