Results 11 to 20 of about 6,041 (204)

Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases [PDF]

Journal of Internal Medicine
AbstractBackgroundClonal hematopoiesis of indeterminate potential (CHIP), characterized by the age‐related expansion of blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate the association between CHIP and established autoimmune diseases.MethodsWe analyzed baseline data from 456,692 UK Biobank ...
Hanzhang Wu, Yuefeng Yu, Ningjian Wang   +2 more
exaly   +4 more sources

p53 involvement in clonal hematopoiesis of indeterminate potential [PDF]

Current Opinion in Hematology, 2019
Purpose of review Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and occurs when a single mutant hematopoietic stem cell (HSC) contributes to a significant clonal proportion of mature blood lineages.
Chen, Sisi, Liu, Yan
core   +3 more sources

Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort [PDF]

Cardio-Oncology
Background Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to increase all-cause mortality and risk of cardiomyopathy in patients with solid malignancies.
Rachel Jaber Chehayeb, Jaiveer Singh, Carlos Matute-Martinez, Nathan W. Chen, Ana Ferrigno Guajardo, Derrick Lin, Ritujith Jayakrishnan, Anthos Christofides, Etienne Leveille, Yunju Im, Giulia Biancon, Jennifer VanOudenhove, Eiman Ibrahim, Anastasias Ardasheva, Alokkumar Jha, John Hwa, Stephanie Halene, Jennifer M. Kwan   +17 more
doaj   +2 more sources

Clonal hematopoiesis of indeterminate potential is a risk factor of gastric cancer: A Prospective Cohort in UK Biobank study [PDF]

Translational Oncology
Importance: Gastric cancer is often diagnosed at an advanced stage and at order age, identification of high-risk population is needed for detection of early-stage gastric cancer.
Zhihui Xi, Huolun Feng, Kunling Chen, Xin Guo, Dandan Zhu, Jiabin Zheng, Yong Li   +6 more
doaj   +2 more sources

The Predictive Value of Hemoglobin Glycation Index and Clonal Hematopoiesis of Indeterminate Potential Among AMI Patients—A Prospective Registry Study [PDF]

Journal of Diabetes
Aims The objective of this research is to explore the combined effect of hemoglobin glycation index (HGI) and clonal hematopoiesis of indeterminate potential (CHIP) on all‐cause mortality among patients diagnosed with acute myocardial infarction (AMI ...
Linghan Xue, Wenhao Dong, Jiannan Li, Runzhen Chen, Nan Li, Chen Liu, Peng Zhou, Yi Chen, Li Song, Xiaoxiao Zhao, Hongbing Yan, Hanjun Zhao   +11 more
doaj   +2 more sources

Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study [PDF]

Cardiovascular Diabetology
Background Clonal hematopoiesis of indeterminate potential (CHIP) was associated with diabetes and cardiovascular diseases (CVD). However, the effect of CHIP on CVD have not been evaluated among patients with diabetes, and whether maintaining the healthy
Ying Sun, Yuefeng Yu, Lingli Cai, Bowei Yu, Wenying Xiao, Xiao Tan, Yu Wang, Yingli Lu, Ningjian Wang   +8 more
doaj   +2 more sources

Clonal hematopoiesis of indeterminate potential: a multisystem hub bridging hematopoietic dysfunction with non-hematopoietic diseases [PDF]

Military Medical Research
Clonal hematopoiesis of indeterminate potential (CHIP), driven by leukemia-related somatic mutations in hematopoietic stem cells, previously recognized as a major risk factor for hematological malignancies, has now emerged as a potent risk factor for ...
Jing-Lei Zhang, Shuo-Lan Tong, Qi-Qi Zhuang, Sheng-Jie Jin, Jia-Qiu Li, Jie Sun   +5 more
doaj   +2 more sources

Clonal hematopoiesis of indeterminate potential in patients with immunoglobulin light-chain AL amyloidosis. [PDF]

Blood Adv
Immunoglobulin light chain (AL) amyloidosis is characterized by the deposition of misfolded monoclonal free light chains, with cardiac complications accounting for patients' mortality.
Lopedote P, Evans B, Marchetti A, Chen T, Moscvin M, Boullt S, Bolli N, Bianchi G.   +7 more
europepmc   +3 more sources

Increased frequency of clonal hematopoiesis of indeterminate potential in Bloom syndrome probands and carriers [PDF]

Haematologica
Not available.
Isabella Lin, Angela Wei, Tsumugi A. Gebo, Paul C. Boutros, Maeve Flanagan, Nicole Kucine, Christopher Cunniff, Valerie A. Arboleda, Vivian Y. Chang   +8 more
doaj   +2 more sources

Telomere Length and Clonal Hematopoiesis of Indeterminate Potential: A Loop Between Two Key Players in Aortic Valve Disease? [PDF]

Journal of Cardiovascular Development and Disease
Aortic valve stenosis (AVS) is the most common valvular heart disease that was considered, for a long time, a passive degenerative disease due to physiological aging.
Ilenia Foffa, Augusto Esposito, Ludovica Simonini, Sergio Berti, Cecilia Vecoli   +4 more
doaj   +2 more sources