Results 21 to 30 of about 173,423,441 (192)
Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV [PDF]
Scientific Reports, 2022 People living with human immunodeficiency virus (PLWH) have significantly increased risk for cardiovascular disease in part due to inflammation and immune dysregulation.Alexander G. Bick, Konstantin Popadin, Christian W. Thorball, Md Mesbah Uddin, Markella V. Zanni, Bing Yu, Matthias Cavassini, Andri Rauch, Philip Tarr, Patrick Schmid, Enos Bernasconi, Huldrych F. Günthard, Peter Libby, Eric Boerwinkle, Paul J. McLaren, Christie M. Ballantyne, Steven Grinspoon, Pradeep Natarajan, Jacques Fellay, the Swiss HIV Cohort Study +19 moredoaj +4 more sourcesMendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential [PDF]
, 2022 Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies.de Las Fuentes, Lisa, Nakao, Tetsushi, et al,, Gu, C Charles, Nelson, Christopher, Cupples, L Adrienne, de Andrade, Mariza, Peralta, Juan M, Arnett, Donna K, Vasan, Ramachandran S, Nelson, Christopher P, Pampana, Akhil, Niroula, A., Ellinor, Patrick T, Clarke, Shoa L, Zekavat, Seyedeh M., Rotter, Jerome I, Smith, Nicholas L, Boorgula, Meher, Minster, Ryan L, Weeks, Daniel E, Samani, Nilesh, Lloyd-Jones, Donald M, Hawley, Nicola L, Bick, Alexander G., Fornage, Myriam, Bhattacharya, Romit, Post, Wendy, Deka, Ranjan, Morrison, Alanna C, Yanek, Lisa R, Curran, Joanne E, Kardia, Sharon LR, Musani, Solomon K, Samani, Nilesh J, Kardia, Sharon L R, Laurie, Cecelia A, Darbar, Dawood, DeMeo, Dawn L, Yoneda, Zachary T, Lifestyle and Genetic Adaptations Study (OLaGA) Group, Peloso, Gina M, Mathias, Rasika A, Bis, Joshua C, Desai, Pinkal, Uddin, Md M, Hixson, James E, Nakao, T.,, Lund University., Roden, Dan M, Pace, Betty S, Hwu, Chii-Min, Konkle, Barbara A, Redline, Susan, McGarvey, Stephen T, Chen, Yii-Der Ida, Palmer, Nicholette D, Loos, Ruth J F, Johnsen, Jill M, Boerwinkle, Eric, Bowden, Donald W, Whitsel, Eric A, Danesh, John, Tracy, Russell P, Stilp, Adrienne M, Reupena, Muagututi\u27a S, Zhao, Wei, Psaty, Bruce M, Heckbert, Susan R, Bick, Alexander G, Smith, Albert V, Kooperberg, Charles, Weinstock, Joshua S, Jaiswal, Siddhartha, Meyers, Deborah A, Cho, Michael H, Ebert, Benjamin L, Wong, Quenna, Reiner, Alexander P, Pankratz, Nathan, Gibson, Christopher J, Kaplan, Robert C, Shuldiner, Alan R, Rich, Stephen S, Curran, Joanne E., Kelly, Shannon, Tiwari, Hemant K, North, Kari E, Naseri, Take T, Custer, Brian S, Barnes, Kathleen C, Codd, Veryan, Becker, Lewis C, Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, Kenny, Eimear E, Freedman, Barry I, Carty, Cara L, Emery, Leslie S, Chavan, Sameer, Honigberg, Michael C, Uddin, Md M., Zekavat, Seyedeh M, Taub, Margaret A, Irvin, Marguerite R, Qiao, Dandi, Vries, Paul S, Weiss, Scott T, Peralta, Juan M., Broome, Jai, Raffield, Laura M, Mitchell, Braxton D, Preuss, Michael, Natarajan, Pradeep, Griffin, Gabriel K, Correa, Adolfo, Manson, JoAnn E, Taub, Margaret A., Do, Ron,, Khan, Alyna T, Wiggins, Kerri L, Assimes, Themistocles L, Niroula, Abhishek, Reupena, Muagututi’a S, Niroula, A.,, Peyser, Patricia A, Lane, John, Blackwell, Thomas W, Nakao, T., Kelly, Tanika N, He, Jiang, Libby, Peter, Ballantyne, Christie M, Smith, Jennifer A, Silverman, Edwin K, Hidalgo, Bertha, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Shoemaker, M Benjamin, Blangero, John, Abecasis, Gonçalo R, Do, Ron, Mariza de Andrade, C. Charles Gu, Assimes, Themistocles L., Susan R. Heckbert, Jiang He, Honigberg, Michael C., Robert C. Kaplan, Bruce M. Psaty, L. Adrienne Cupples, John Danesh, Daniel E. Weeks, Scott T. Weiss, null null, Eimear E. Kenny, Kari E. North, Nicholas L. Smith, Jennifer A. Smith, Yii-Der Ida Chen, Patrick T. Ellinor, Benjamin L. Ebert, Tetsushi Nakao, Stilp, Adrienne M., Tanika N. Kelly, Margaret A. Taub, Muagututi’a S. Reupena, DeMeo, Dawn L., Wiggins, Kerri L., John Blangero, Pradeep Natarajan, Dan M. Roden, North, Kari E., Laura M. Raffield, Charles Kooperberg, Carty, Cara L., John Lane, Patricia A. Peyser, Albert V. Smith, Quenna Wong, Nicholette D. Palmer, Veryan Codd, Gonçalo R. Abecasis, Barbara A. Konkle, Donald M. Lloyd-Jones, Peter Libby, Meher Boorgula, Charles Gu, C., Gina M. Peloso, Kerri L. Wiggins, Seyedeh M. Zekavat, Jerome I. Rotter, Khan, Alyna T., Michael H. Cho, Siddhartha Jaiswal, Bertha Hidalgo, Marguerite R. Irvin, Donna K. Arnett, Weinstock, Joshua S., Gibson, Christopher J., Tracy, Russell P., Cecelia A. Laurie, Griffin, Gabriel K., Wei Zhao, Edwin K. Silverman, Alexander G. Bick, Laurie, Cecelia A., Nicola L. Hawley, Solomon K. Musani, Eric A. Whitsel, Russell P. Tracy, Emery, Leslie S., Zachary T. Yoneda, Betty S. Pace, Bis, Joshua C., JoAnn E. Manson, Christopher J. Gibson, Johnsen, Jill M., Alyna T. Khan, Loos, Ruth J.F., Ramachandran S. Vasan, Braxton D. Mitchell, Blackwell, Thomas W., Christie M. Ballantyne, Cara L. Carty, Nilesh J. Samani, Hixson, James E., Brian S. Custer, Bowden, Donald W., Deborah A. Meyers, Adolfo Correa, Irvin, Marguerite R., Donald W. Bowden, Kathleen C. Barnes, Lewis C. Becker, Wendy Post, Yanek, Lisa R., Thomas W. Blackwell, Musani, Solomon K., Themistocles L. Assimes, Lisa R. Yanek, Paul S. Vries, Rasika A. Mathias, Peloso, Gina M., Lisa de las Fuentes, Ron Do, Roden, Dan M., Nelson, Christopher P., Sameer Chavan, Hemant K. Tiwari, Reupena, Muagututi'a S., Juan M. Peralta, Chii-Min Hwu, Joshua S. Weinstock, Susan Redline, Yoneda, Zachary T., Sharon L.R. Kardia, Smith, Albert V., Gabriel K. Griffin, Alan R. Shuldiner, Hwu, Chii Min, Pinkal Desai, Ranjan Deka, Ryan L. Minster, Christopher P. Nelson, Joanne E. Curran, Alanna C. Morrison, M. Benjamin Shoemaker, Dandi Qiao, Stephen T. McGarvey, Adrienne M. Stilp, Jai Broome, Joshua C. Bis, Shannon Kelly, Nathan Pankratz, Alexander P. Reiner, Barry I. Freedman, Take T. Naseri, Myriam Fornage, Ruth J.F. Loos, Michael Preuss, Eric Boerwinkle, Romit Bhattacharya, Stephen S. Rich, Clarke, Shoa L., Leslie S. Emery, Dawood Darbar, Dawn L. DeMeo, Lloyd-Jones, Donald M., Abhishek Niroula, Jill M. Johnsen, James E. Hixson, Shoa L. Clarke, Md M. Uddin, Michael C. Honigberg, Akhil Pampana +293 morecore +13 more sourcesClonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease [PDF]
Nature Communications, 2022 Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs.M d Mesbah Uddin, Ngoc Quynh H. Nguyen, Bing Yu, Jennifer A. Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S. Weinstock, Michael C. Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K. Griffin, Varuna Chander, Richard A. Gibbs, Jerome I. Rotter, Chunyu Liu, Andrea A. Baccarelli, Daniel I. Chasman, Eric A. Whitsel, Douglas P. Kiel, Joanne M. Murabito, Eric Boerwinkle, Benjamin L. Ebert, Siddhartha Jaiswal, James S. Floyd, Alexander G. Bick, Christie M. Ballantyne, Bruce M. Psaty, Pradeep Natarajan, Karen N. Conneely +31 moredoaj +4 more sourcesExtramedullary Clonal Hematopoiesis with Indeterminate Potential [PDF]
Clinical Lymphoma Myeloma and Leukemia, 2021 Clinical Practice Points • We present here the case of an otherwise healthy male patient with paravertebral tumors with histological findings of extramedullary hematopoiesis (EH). • The hematological assessment could not confirm a hematological disease.Florian, Ramdohr, Astrid, Monecke, Madlen, Jentzsch, Thomas, Zehrfeld, Gudrun, Borte, Sebastian, Schwind, Georg-Nikolaus, Franke, Klaus H, Metzeler, Uwe, Platzbecker, Vladan, Vucinic +9 moreopenaire +2 more sourcesTranslating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review [PDF]
, 2020 Some random mutations can confer a selective advantage to a hematopoietic stem cell. As a result, mutated hematopoietic stem cells can give rise to a significant proportion of mutated clones of blood cells.Vaccarezza, Mauro, Francesca Fortini, Gianluca Campo, Paola Rizzo, Papa, V., Vieceli Dalla Sega, F, Marracino, L., Mauro Vaccarezza, Rizzo, P., Fortini, F., Campo, G., Veronica Papa, Francesco Vieceli Dalla Sega, Luisa Marracino +13 morecore +2 more sourcesClonal hematopoiesis of indeterminate potential is associated with acute kidney injury
Nature MedicineAbstract Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential (CHIP) confers increased risk for several chronic diseases associated with aging.Caitlyn Vlasschaert, Cassianne Robinson-Cohen, Jianchun Chen, Elvis Akwo, Alyssa C. Parker, Samuel A. Silver, Pavan K. Bhatraju, Hannah Poisner, Shirong Cao, Ming Jiang, Yinqiu Wang, Aolei Niu, Edward Siew, Joseph C. Van Amburg, Holly J. Kramer, Anna Kottgen, Nora Franceschini, Bruce M. Psaty, Russell P. Tracy, Alvaro Alonso, Dan E. Arking, Josef Coresh, Christie M. Ballantyne, Eric Boerwinkle, Morgan Grams, Ming-Zhi Zhang, Bryan Kestenbaum, Matthew B. Lanktree, Michael J. Rauh, Raymond C. Harris, Alexander G. Bick +30 moreopenaire +4 more sourcesClonal Hematopoiesis of Indeterminate Potential [PDF]
Deutsches Ärzteblatt international, 2016 Patients with cytopenia are increasingly undergoing molecular genetic tests of periperal blood or bone marrow for diagnostic purposes. These tests can detect genetic mutations that do not have any morphological correlate in hematologic neoplasia such as myelo - dysplastic syndrome (MDS). A new entity was recently defined to lessen the risk of incorrect Michael, Heuser, Felicitas, Thol, Arnold, Ganser +2 moreopenaire +2 more sourcesClonal Hematopoiesis of Indeterminate Potential After Radiation Therapy. [PDF]
Int J Radiat Oncol Biol PhysClonal hematopoiesis of indeterminate potential (CHIP) is a condition associated with increased risk of hematologic malignancies and cardiovascular diseases. Although radiation therapy has been identified as a risk factor for CHIP, specific radiation factors that influence the development of CHIP remain unclear.We identified 489 patients with cancer ...Crants SA, Olson SS, Li Y, Bejan CA, Vlasschaert C, Mack TM, Pershad Y, Kishtagari A, Reed SC, Croessmann S, Roden DM, Osterman TJ, Shinohara ET, Bick AG, Park BH, Luo LY. +15 moreeuropepmc +3 more sourcesAssociation of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD [PDF]
, 2022 Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate ...Hadzic, S., Norbert Weissmann, Savai, R., Fleming, Ingrid, Michael A. Rieger, Mario Looso, Klatt, Stephan, Natascha Sommer, Kuhnert, Stefan, Seeger, W., Rajkumar Savai, Jochen Wilhelm, Avci, Edibe, Stephan Klatt, Robert Bals, Pullamsetti, S., Claus Vogelmeier, Klatt, S., Andreas Zeiher, Ingrid Fleming, Stefan Kuhnert, Mansouri, Siavash, Stefan Hadzic, Edibe Avci, Zeiher, A., Zeiher, Andreas, Díaz-Piña, Gabriela, Soni S. Pullamsetti, Acker, T., Looso, M., Bals, R., Savai, Rajkumar, Vogelmeier, Claus, Fleming, I., Sommer, N., Pullamsetti, Soni S., Weissmann, Norbert, Diaz-Pina, G., Seeger, Werner, Gabriela Díaz-Piña, Vogelmeier, C., Weissmann, N., Dimmeler, S., Werner Seeger, Bals, Robert, Rieger, Michael A., Sommer, Natascha, Rieger, M., Looso, Mario, Hadzic, Stefan, Manju Padmasekar, Till Acker, Padmasekar, Manju, Padmasekar, M., Mansouri, S., Avci, E., Acker, Till, Kuhnert, S., Wilhelm, J., Stefanie Dimmeler, Dimmeler, Stefanie, Siavash Mansouri, Wilhelm, Jochen +62 morecore +1 more source
