Genetics of smoking and risk of clonal hematopoiesis
Scientific Reports, 2022 Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing expanded somatic mutations have been linked to both oncologic and non-oncologic clinical ...
Michael G. Levin +8 more
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[Correspondence] Clonal hematopoiesis and atherosclerosis [PDF]
, 2017 Jaiswal et al. report the results of four case–control studies that confirm a near doubling in the risk of coronary heart disease in patients with CHIP,1 a finding that was first reported in the Journal in 2014.2 The authors postulate that two mechanisms
Chaudry, Sabah +2 more
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Inflammation in Myeloid Malignancies: From Bench to Bedside [PDF]
Journal of Immunotherapy and Precision Oncology, 2021 Myeloid malignancies, stemming from a somatically mutated hematopoietic clone, can cause a wide variety of clinical consequences, including pancytopenia in myelodysplastic syndrome, overproduction of three myeloid lineages in myeloproliferative neoplasm,
Eli M. Soyfer, Angela G. Fleischman
doaj +1 more source
Cytopenia levels for aiding establishment of the diagnosis of Myelodysplastic Syndromes [PDF]
, 2016 We recommend that standard hematologic values be used to define cytopenias in MDS and believe a modification of the WHO definition of cytopenias as 1 of the criteria (in addition to definitive morphologic and/or cytogenetic findings) to diagnose MDS ...
Alessandro Levis +50 more
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JAK2V617F-positive clonal hematopoiesis of indeterminate potential in pregnant women
Акушерство, гинекология и репродукция, 2019 Aim: to assess the prevalence of V617F somatic mutation of the JAK2 gene in pregnant women.Materials and methods. This non-interventional study was performed in the framework of routine clinical practice and included 1532 samples of venous blood from ...
I. A. Olkhovskiy +7 more
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Epigenetic guardian: a review of the DNA methyltransferase DNMT3A in acute myeloid leukaemia and clonal haematopoiesis [PDF]
, 2017 Acute myeloid leukaemia (AML) is a haematological malignancy characterized by clonal stem cell proliferation and aberrant block in differentiation. Dysfunction of epigenetic modifiers contributes significantly to the pathogenesis of AML.
Chaudry, Sabah, Chevassut, Timothy
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The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]
, 2020 Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J +3 more
core
Platelets as mediators of Thromboinflammation in chronic Myeloproliferative Neoplasms [PDF]
, 2019 Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood cell counts.
Heller, Paula Graciela +1 more
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Copy number alterations detected as clonal hematopoiesis of indeterminate potential
Blood Advances, 2017 : Recent studies have revealed that clonal hematopoiesis of indeterminate potential (CHIP) is an important risk factor for therapy-related myeloid neoplasms (t-MNs).
Koichi Takahashi +16 more
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The global clonal complexity of the murine blood system declines throughout life and after serial transplantation. [PDF]
, 2019 Although many recent studies describe the emergence and prevalence of "clonal hematopoiesis of indeterminate potential" in aged human populations, a systematic analysis of the numbers of clones supporting steady-state hematopoiesis throughout mammalian ...
Bi, W +8 more
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