Results 41 to 50 of about 173,423,441 (192)

JAK2V617F-positive clonal hematopoiesis of indeterminate potential in pregnant women

Акушерство, гинекология и репродукция, 2019
Aim: to assess the prevalence of V617F somatic mutation of the JAK2 gene in pregnant women.Materials and methods. This non-interventional study was performed in the framework of routine clinical practice and included 1532 samples of venous blood from ...
I. A. Olkhovskiy, J. G. Garber, A. S. Gorbenko, M. A. Stolyar, O. M. Miller, E. S. Kostina, Yu. Yu. Komarovskiy, V. V. Potilitsina   +7 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Events: Issues to be Further Explored. [PDF]

J Am Soc Nephrol
Wang Z, Liu P.
europepmc   +5 more sources

A framework for the molecular identification of CHIP for clinical research

HGG Advances
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with many diseases of aging. Large research initiatives are needed to develop clinical guidelines for the management of individuals with CHIP and their risk of disease. However,
Philip Harraka, Robert L. O’Reilly, Jared Burke, Paul Yeh, Kerryn Howlett, Kiarash Behrouzfar, Daniele Belluoccio, Amanda Rewse, Brigid M. Lynch, Kristen J. Bubb, Stephen J. Nicholls, Roger L. Milne, Melissa C. Southey   +12 more
doaj   +1 more source

Copy number alterations detected as clonal hematopoiesis of indeterminate potential

Blood Advances, 2017
: Recent studies have revealed that clonal hematopoiesis of indeterminate potential (CHIP) is an important risk factor for therapy-related myeloid neoplasms (t-MNs).
Koichi Takahashi, Feng Wang, Hagop Kantarjian, Xingzhi Song, Keyur Patel, Sattva Neelapu, Curtis Gumbs, Latasha Little, Samantha Tippen, Rebecca Thornton, Courtney D. DiNardo, Farhad Ravandi, Carlos Bueso-Ramos, Jianhua Zhang, Xifeng Wu, Guillermo Garcia-Manero, P. Andrew Futreal   +16 more
doaj   +1 more source

Hematopoiesis of Indeterminate Potential and Atherothrombotic Risk

, 2022
Hematopoiesis is the process of blood production, essential for the continued supply of immune cells and red blood cells. However, the proliferative nature of hematopoietic stem cells (HSCs) renders them susceptible to developing somatic mutations.
Wang, N, Murphy, AJ, Dragoljevic, D, Natarajan, P   +3 more
core   +1 more source

Clonal hematopoiesis of indeterminate potential and outcomes after heart transplantation: A multicenter study [PDF]

, 2023
Cardiac allograft vasculopathy (CAV) is a leading cause of late graft failure and mortality after heart transplantation (HT). Sharing some features with atherosclerosis, CAV results in diffuse narrowing of the epicardial coronaries and microvasculature ...
Amancherla, Kaushik, Moslehi, Javid, Sarah B. See, Kaushik Amancherla, Clerkin, Kevin, Brandon D. Lowery, Vlasschaert, Caitlyn, Zorn, Emmanuel, Kelly H. Schlendorf, Emmanuel Zorn, Uriel, Nir, Lindenfeld, JoAnn, Ravi V. Shah, Muredach P. Reilly, JoAnn Lindenfeld, Javid Moslehi, Jane E. Freedman, Nir Uriel, Paolo C. Colombo, Alexander G. Bick, Quinn S. Wells, Kevin Clerkin, Caitlyn Vlasschaert, Shah, Ravi V, See, Sarah B, Wells, Quinn S, Reilly, Muredach P, Bick, Alexander G, Schlendorf, Kelly H, Colombo, Paolo C, Lowery, Brandon D, Freedman, Jane E   +31 more
core   +1 more source

Obesity and Clonal Hematopoiesis of Indeterminate Potential: Allies in Cardiovascular Diseases and Malignancies

Life, 2023
The clonal hematopoiesis of indeterminate potential (CHIP) is a term used to describe individuals who have detectable somatic mutations in genes commonly found in individuals with hematologic cancers but without any apparent evidence of such conditions ...
Luka Komic, Marko Kumric, Hrvoje Urlic, Azer Rizikalo, Marko Grahovac, Jelena Kelam, Marion Tomicic, Doris Rusic, Tina Ticinovic Kurir, Josko Bozic   +9 more
doaj   +1 more source

COPD makes CHIP less indeterminate [PDF]

, 2022
In this issue of Blood, Miller and colleagues convincingly demonstrated the contribution of clonal hematopoiesis of indeterminate potential (CHIP) to the risk of chronic obstructive pulmonary disease (COPD).(1) Their epidemiological data are supported ...
Huls, Gerwin, Gerwin Huls
core   +1 more source

Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms

Nature Communications
Clonal hematopoiesis of indeterminate potential is the primary pathogenic risk factor for myeloid neoplasms, while heteroplasmy (mutations in a subset of cellular mitochondrial DNA) is another marker of clonal expansion associated with hematological ...
Yun Soo Hong, Sergiu Pasca, Wen Shi, Daniela Puiu, Nicole J. Lake, Monkol Lek, Meng Ru, Megan L. Grove, Anna Prizment, Corinne E. Joshu, Elizabeth A. Platz, Eliseo Guallar, Dan E. Arking, Lukasz P. Gondek   +13 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source