Results 61 to 70 of about 173,423,441 (192)

Treatment of clonal hematopoiesis associated atherosclerosis via vaccine-based clearance of the mutant cells

Journal of Advanced Research
Introduction: Clonal hematopoiesis of indeterminate potential (CHIP), driven by somatic mutations (e.g., TET2 ), is an independent risk factor for atherosclerosis (AS).
Shuang Liang, Wenxin Tao, Di Qu, Panpan Ji, Zhenzhen Hao, Mengying Wei, Guodong Yang, Xueying Zhou, Chen Wang, Lijun Yuan   +9 more
doaj   +1 more source

Clonal hematopoiesis of indeterminate potential (CHIP) and cardiovascular diseases—an updated systematic review

Journal of Genetic Engineering and Biotechnology, 2021
Background Cardiovascular diseases (CVDs) are the leading cause of mortality in India. Residual risk exists in patients receiving optimal guideline-directed medical therapy.
Nagendra Boopathy Senguttuvan, Vinodhini Subramanian, Vettriselvi Venkatesan, T. R. Muralidharan, Kavitha Sankaranarayanan   +4 more
doaj   +1 more source

Long Telomeric Repeat-Containing RNA (TERRA): Biological Functions and Challenges in Vascular Aging and Disease

Biomedicines, 2023
Telomere dysfunction is implicated in vascular aging and shorter leucocyte telomeres are associated with an increased risk of atherosclerosis, myocardial infarction, and heart failure.
Paola Canale, Jonica Campolo, Andrea Borghini, Maria Grazia Andreassi   +3 more
doaj   +1 more source

Subset‐specific and tissue‐specific expression of NK‐cell markers and killer immunoglobulin‐like receptors: Implications for NK‐cell clonality assessment

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate immunophenotypic evaluation of natural killer (NK)‐cell neoplasms is challenging because NK‐cells lack somatically rearranged antigen receptors, are comprised of phenotypically distinct subsets, and exhibit tissue‐specific subset distribution. We developed a flow cytometry (FC) panel for NK‐cell immunophenotypic analysis and clonality
Valerie Woodings, Orrin Koepke, Jason E. Love, Alireza Torabi, Lianqun Qiu, Jonathan R. Fromm, Sindhu Cherian, Afshin Shameli   +7 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort

Cardio-Oncology
Background Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to increase all-cause mortality and risk of cardiomyopathy in patients with solid malignancies.
Rachel Jaber Chehayeb, Jaiveer Singh, Carlos Matute-Martinez, Nathan W. Chen, Ana Ferrigno Guajardo, Derrick Lin, Ritujith Jayakrishnan, Anthos Christofides, Etienne Leveille, Yunju Im, Giulia Biancon, Jennifer VanOudenhove, Eiman Ibrahim, Anastasias Ardasheva, Alokkumar Jha, John Hwa, Stephanie Halene, Jennifer M. Kwan   +17 more
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Obesity-induced inflammation exacerbates clonal hematopoiesis

, 2023
Characterized by the accumulation of somatic mutations in blood cell lineages, clonal hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the expansion of mutated hematopoietic stem and progenitor cells (HSC/Ps) that leads ...
Pandhiri, Taruni Reddy, Niroula, Abhishek, Sandusky, George E., Yellapu, Nanda Kumar, Yu, Zhi, Ebert, Benjamin L., Natarajan, Pradeep, Kapur, Reuben, Griffin, Gabriel K., Pasupuleti, Santhosh Kumar, Kanumuri, Rahul, Paczesny, Sophie, Dave, Utpal P., Bick, Alexander G., Ramdas, Baskar, Honigberg, Michael C., Kumar, Ramesh, Zhou, Xinyu, Zhang, Chi, Burns, Sarah S., Palam, Lakshmi Reddy   +20 more
core   +1 more source

Prevalence and significance of clonal hematopoiesis of indeterminate potential in lung transplant recipients

BMC Pulmonary Medicine, 2023
Background Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition of somatic mutations that leads to an expanded blood cell clone, has been associated with development of a pro-inflammatory state.
Aparna C. Swaminathan, Richard Barfield, Mengqi Zhang, Gundula Povysil, Cliburn Chen, Courtney Frankel, Francine Kelly, Matthew McKinney, Jamie L. Todd, Andrew Allen, Scott M. Palmer   +10 more
doaj   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source