Results 61 to 70 of about 6,041 (204)

Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T‐cell lymphoma [PDF]

, 2018
journal ...
CHIBA Shigeru, Fukumoto Kota, Nguyen Tran B., SAKATA-YANAGIMOTO Mamiko   +3 more
core   +2 more sources

Prevalence and significance of clonal hematopoiesis of indeterminate potential in lung transplant recipients

BMC Pulmonary Medicine, 2023
Background Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition of somatic mutations that leads to an expanded blood cell clone, has been associated with development of a pro-inflammatory state.
Aparna C. Swaminathan, Richard Barfield, Mengqi Zhang, Gundula Povysil, Cliburn Chen, Courtney Frankel, Francine Kelly, Matthew McKinney, Jamie L. Todd, Andrew Allen, Scott M. Palmer   +10 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk. [PDF]

, 2023
ObjectiveClonal hematopoiesis of indeterminate potential (CHIP) is an aging-related accumulation of somatic mutations in hematopoietic stem cells, leading to clonal expansion.
Bick, Alexander G, Carson, April P, Collins, Jason, Correa, Adolfo, Cupples, L Adrienne, Dicorpo, Daniel, Dupuis, Josée, Fornage, Myriam, Goodarzi, Mark O, Guo, Xiuqing, Howard, Barbara, Kooperberg, Charles, Lange, Leslie A, Liu, Simin, Manning, Alisa K, Manson, JoAnn E, Meigs, James, Psaty, Bruce M, Raffield, Laura M, Raghavan, Sridharan, Reiner, Alex P, Rich, Stephen S, Rotter, Jerome I, Taylor, Kent D, Tinker, Lesley, Tobias, Deirdre K, Vasan, Ramachandran S, Wessel, Jennifer, Westerman, Kenneth E, Whitsel, Eric A, Wilson, James G, Wu, Peitao   +31 more
core   +2 more sources

Clonal hematopoiesis of indeterminate potential as a prognostic factor: a systematic review and meta-analysis [PDF]

Blood Advances
Jasmine Singh, Le thi Phuong Thao, David J Curtis   +2 more
exaly   +2 more sources

Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms

Nature Communications
Clonal hematopoiesis of indeterminate potential is the primary pathogenic risk factor for myeloid neoplasms, while heteroplasmy (mutations in a subset of cellular mitochondrial DNA) is another marker of clonal expansion associated with hematological ...
Yun Soo Hong, Sergiu Pasca, Wen Shi, Daniela Puiu, Nicole J. Lake, Monkol Lek, Meng Ru, Megan L. Grove, Anna Prizment, Corinne E. Joshu, Elizabeth A. Platz, Eliseo Guallar, Dan E. Arking, Lukasz P. Gondek   +13 more
doaj   +1 more source

The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer: A Report of the Association for Molecular Pathology [PDF]

, 2016
Clinical utility describes the benefits of each laboratory test for that patient. Many stakeholders have adopted narrow definitions for the clinical utility of molecular testing as applied to targeted pharmacotherapy in oncology, regardless of the ...
Cankovic, Milena, Caughron, Samuel, Chandra, Pranil, Emmadi, Rajyasree, Hagenkord, Jill, Hallam, Stephanie, Jewell, Kay E., Joseph, Loren, Klein, Roger, Lyon, Elaine, Pratt, Victoria M., Rothberg, Paul G., Temple-Smolkin, Robyn L.   +12 more
core   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Inflammatory reprogramming of the solid tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes

Cell Reports Medicine
Summary: Clonal hematopoiesis (CH)—the expansion of somatically mutated hematopoietic cells—is common in solid cancers. CH is associated with systemic inflammation, but its impact on tumor biology is underexplored.
Marco M. Buttigieg, Caitlyn Vlasschaert, Alexander G. Bick, Robert J. Vanner, Michael J. Rauh   +4 more
doaj   +1 more source

The Secondary Myelodysplastic Neoplasms (MDS) Jigsaw [PDF]

, 2023
Predisposición genética; Neoplasias mielodisplásicasPredisposició genètica; Neoplàsies mielodisplàsiquesGenetic predisposition; Myelodysplastic neoplasmsThere is a great deal of controversy in the hematologic community regarding the classification of ...
Calvete, Oriol, Jerez Cayuela, Andres, Mestre, Júlia, Solé, Francesc   +3 more
core   +2 more sources

Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19

Frontiers in Immunology, 2022
Clonal hematopoiesis of indeterminate potential (CHIP) leads to higher mortality, carries a cardiovascular risk and alters inflammation. All three aspects harbor overlaps with the clinical manifestation of COVID-19.
Judith Schenz, Katharina Rump, Katharina Rump, Benedikt Hermann Siegler, Inga Hemmerling, Tim Rahmel, Jan N. Thon, Hartmuth Nowak, Hartmuth Nowak, Dania Fischer, Anna Hafner, Lucas Tichy, Katharina Bomans, Manja Meggendorfer, Björn Koos, Björn Koos, Thilo von Groote, Thilo von Groote, Alexander Zarbock, Alexander Zarbock, Mascha O. Fiedler, Johanna Zemva, Jan Larmann, Uta Merle, Michael Adamzik, Michael Adamzik, Carsten Müller-Tidow, Torsten Haferlach, Florian Leuschner, Markus A. Weigand, Markus A. Weigand   +30 more
doaj   +1 more source