Results 81 to 90 of about 173,423,441 (192)

Clonal Hematopoiesis of Indeterminate Potential as a Novel Risk Factor for Donor-Derived Leukemia

, 2020
Hematopoietic stem cell transplantation (HSCT) is a critical treatment modality for many hematological and non-hematological diseases that is being extended to treat older individuals.
Burns, Sarah S., Kapur, Reuben
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease

, 2023
Background: Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal expansion of blood stem cells with leukemia-associated mutations—is a novel cardiovascular risk factor.
Peter Libby, Yu, Zhi, Esra D. Gumuser, Nakao, Tetsushi, Ebert, Benjamin L., Sara Haidermota, Uddin, Md Mesbah,, Bick, Alexander G.,, Siddhartha Jaiswal, So Mi Jemma Cho, Bick, Alexander G., Honigberg, Michael C., Uddin, Md Mesbah, Hornsby, Whitney,, Weeks, Lachelle D., Ebert, Benjamin L.,, Schuermans, Art,, Gumuser, Esra D.,, Honigberg, Michael C.,, Cho, So Mi Jemma,, Paruchuri, Kaavya, Nakao, Tetsushi,, Schuermans, Art, Haidermota, Sara, Alexander G. Bick, Libby, Peter,, Lund University., Md Mesbah Uddin, Gumuser, Esra D., Kaavya Paruchuri, Benjamin L. Ebert, Art Schuermans, Tetsushi Nakao, Hornsby, Whitney, Natarajan, Pradeep, Cho, So Mi Jemma, Jaiswal, Siddhartha,, Natarajan, Pradeep,, Sporn, Zachary A.,, Zhi Yu, Zachary A. Sporn, Pradeep Natarajan, Niroula, Abhishek, Whitney Hornsby, Sporn, Zachary A., Yu, Zhi,, Jaiswal, Siddhartha, Libby, Peter, Abhishek Niroula, Weeks, Lachelle D.,, Paruchuri, Kaavya,, Haidermota, Sara,, Niroula, Abhishek,, Lachelle D. Weeks, Michael C. Honigberg   +54 more
core   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source

Prospective characterization of clonal hematopoiesis and its clinical associations in elderly patients

Scientific Reports
Clonal hematopoiesis (CH) is characterized by the expansion of hematopoietic stem cell clones carrying somatic mutations that confer a proliferative advantage, encompassing conditions such as Clonal Hematopoiesis of Indeterminate Potential (CHIP) and ...
Thaís B. Moyen, Victoria Tomaz, Luiz Gustavo F. Cortes, Susana Rosa, Fabio P. S. Santos, Nelson Hamerschlak, Renato D. Puga, Rodrigo D. S. Reis, Roberta C. Petroni, Caroline N. Silveira, Maria Fernanda P. Moretti, Maysa S. Cendoroglo, Paulo V. Campregher   +12 more
doaj   +1 more source

Clonal cytopenia of undetermined significance: definitions, risk and therapeutic targets

Frontiers in Hematology
Cancer-related somatic genetic alterations are detectable in the blood of individuals without hematologic malignancy, reflecting the outgrowth of a mutated stem/progenitor cell population, a phenomenon termed clonal hematopoiesis (CH).
Cristian C. Taborda, Amer M. Zeidan, Lourdes M. Mendez   +2 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Relationship between clonal hematopoiesis of indeterminate potential and severity of coronary stenosis in coronary heart disease patients with renal insufficiency

陆军军医大学学报
Objective To investigate the association between clonal hematopoiesis of indeterminate potential (CHIP) and the severity of coronary artery lesions in coronary heart disease (CHD) patients with renal insufficiency.
ZHONG Jialin, ZHONG Jialin, XIAO Ruonan, XIANG Shuting   +3 more
doaj   +1 more source

Analysis of ADVIA Myeloperoxidase Cytogram LUC Angle Does Not Distinguish Acute Myeloid Leukemia From Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma in Dogs

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Acute myeloid leukemia (AML) is difficult to distinguish from lymphoblastic leukemia or lymphoma (LL) on morphologic features alone. Therapeutic approaches for AML versus LL differ, and immediate therapy is often needed due to patient illness and rapid disease progression.
Mayzie Miller, Nora L. Springer, Dorothee Bienzle, Kristina Meichner, Tracy Stokol   +4 more
wiley   +1 more source