Results 91 to 100 of about 6,041 (204)

Causal relevance of clonal haematopoiesis with cardiac disease and adverse remodelling: a Mendelian randomisation study [PDF]

Background: Many observational studies highlight clonal haematopoiesis (CH) as a novel determinant of cardiovascular disease (CVD). However, disentangling cause and effect from important confounders, such as age and smoking, is challenging.
Ardissino, Maddalena, Carter, Paul, Mead, Adam J, Morley, Alec Peter, Quiros, Pedro M, Raisi-Estabragh, Zahra, Raman, Betty, Vassiliou, George S   +7 more
core   +5 more sources

Somatic Mutations in Acquired Pure Red Cell Aplasia: Incidence and Implications

American Journal of Hematology, EarlyView.
Robert T. Means Jr
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Clonal cytopenia of undetermined significance: definitions, risk and therapeutic targets

Frontiers in Hematology
Cancer-related somatic genetic alterations are detectable in the blood of individuals without hematologic malignancy, reflecting the outgrowth of a mutated stem/progenitor cell population, a phenomenon termed clonal hematopoiesis (CH).
Cristian C. Taborda, Amer M. Zeidan, Lourdes M. Mendez   +2 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential and Progression of CKD

Journal of the American Society of Nephrology
Key Points Non- DNMT3A clonal hematopoiesis of indeterminate potential was associated with CKD progression in a meta-analysis of 5654 individuals with ...
Caitlyn Vlasschaert, Yang Pan, Jianchun Chen, Elvis Akwo, Varun Rao, James E. Hixson, Michael Chong, Md Mesbah Uddin, Zhi Yu, Mengdi Jiang, Fenfen Peng, Shirong Cao, Yinqiu Wang, Do-Kyun Kim, Adriana M. Hung, Jing He, Manjula Kurella Tamura, Debbie L. Cohen, Jiang He, Changwei Li, Zeenat Bhat, Panduranga Rao, Dawei Xie, Alexander G. Bick, Bryan Kestenbaum, Guillaume Paré, Michael J. Rauh, Adeera Levin, Pradeep Natarajan, James P. Lash, Ming-Zhi Zhang, Raymond C. Harris, Cassianne Robinson-Cohen, Matthew B. Lanktree, Tanika N. Kelly   +34 more
openaire   +2 more sources

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Relationship between clonal hematopoiesis of indeterminate potential and severity of coronary stenosis in coronary heart disease patients with renal insufficiency

陆军军医大学学报
Objective To investigate the association between clonal hematopoiesis of indeterminate potential (CHIP) and the severity of coronary artery lesions in coronary heart disease (CHD) patients with renal insufficiency.
ZHONG Jialin, ZHONG Jialin, XIAO Ruonan, XIANG Shuting   +3 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Prospective characterization of clonal hematopoiesis and its clinical associations in elderly patients

Scientific Reports
Clonal hematopoiesis (CH) is characterized by the expansion of hematopoietic stem cell clones carrying somatic mutations that confer a proliferative advantage, encompassing conditions such as Clonal Hematopoiesis of Indeterminate Potential (CHIP) and ...
Thaís B. Moyen, Victoria Tomaz, Luiz Gustavo F. Cortes, Susana Rosa, Fabio P. S. Santos, Nelson Hamerschlak, Renato D. Puga, Rodrigo D. S. Reis, Roberta C. Petroni, Caroline N. Silveira, Maria Fernanda P. Moretti, Maysa S. Cendoroglo, Paulo V. Campregher   +12 more
doaj   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, Volume 159, Issue 2, Page 302-319, 15 July 2026.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source