Results 111 to 120 of about 6,041 (204)

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches

Brain and Behavior, Volume 16, Issue 5, May 2026.
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Ayesha Khan, Arsal Khan, Kuldeep Dalpat Rai, Anzel Saeed, Harsh Kumar, Aneesh Kumar Sangtiani, Tehreem Fatima, Muhammad Tanveer Alam, Faiza Rajput, Sakshi Chawla, Hussain Haider Shah, Humaira Kalam   +11 more
wiley   +1 more source

Loss of Y chromosome in Alzheimer’s patients co-occurs with somatic mutations beyond CHIP drivers

Life Science Alliance
Unknown driver mutations are enriched in Alzheimer’s patients with Y chromosome loss, suggesting LOY-driven clonal myeloid expansion may contribute to distinct disease-associated mutational profiles. Loss of Y chromosome (LOY) and clonal hematopoiesis of
Edyta Rychlicka-Buniowska, Daniil Sarkisyan, Monika Horbacz, Bożena Bruhn-Olszewska, Kinga Drężek-Chyła, Mikołaj Koszyński, Hanna Davies, Ulana Juhas, Magdalena Wójcik-Zalewska, Alicja Klich-Rączka, Lena Kilander, Martin Ingelsson, Karolina Bukowska-Strakova, Kazimierz Węglarczyk, Maciej Siedlar, Jarosław Baran, Janusz Ryś, Arkadiusz Piotrowski, Natalia Filipowicz, Jan P Dumanski   +19 more
doaj   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source

Clonal hematopoiesis of indeterminate potential-related epigenetic age acceleration correlates with clonal hematopoiesis of indeterminate potential clone size in patients with high morbidity

Haematologica, 2022
Jasper David Feldkamp, Valentin Max Vetter, Christopher Maximilian Arends, Tonio Johannes Lukas Lang, Lars Bullinger, Frederik Damm, Ilja Demuth, Mareike Frick   +7 more
doaj   +1 more source

Aptamer‐Functionalized Nanocarriers for Bone and Joint Diseases: Engineering Design Rules and Translational Roadmap

Small Science, Volume 6, Issue 5, May 2026.
Aptamer‐functionalized nanocarriers represent a versatile platform for targeted therapy in bone and joint diseases. This review presents five complementary design strategies: free aptamers for soluble targets, bispecific multivalent constructs for enhanced avidity, nanoparticle‐conjugated aptamers for selective tissue accumulation, aptamer‐based ...
Hamdi Al‐Azzani, Djandan Tadum Arthur Vithran, Syeda Sundas Batool, Malek Mohammed Ali Alshabi, Wenhu Zhou, Xiaoqiang Mao   +5 more
wiley   +1 more source

Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study

Pharmacological Research
Clonal hematopoiesis of indeterminate potential (CHIP) is a prominent risk factor for atherosclerosis, but effective medications for CHIP-associated risk are still lacking.
Runzhen Chen, Jiannan Li, Shaodi Yan, Xiaoxiao Zhao, Jinying Zhou, Nan Li, Linghan Xue, Weida Liu, Peng Zhou, Chen Liu, Yi Chen, Yu Tan, Li Song, Hongbing Yan, Hanjun Zhao   +14 more
doaj   +1 more source

Circulating tumour cells (CTCs) in haematological malignancies: Advances in biology and clinical relevance with a focus on multiple myeloma

British Journal of Haematology, Volume 208, Issue 5, Page 1535-1550, May 2026.
Spatial heterogeneity limits the sensitivity of bone marrow biopsies, resulting in false‐negative findings. Circulating tumour cells (CTCs) provide a systemic, stratified monitoring approach, using flow cytometry for high tumour burden and EuroFlow or allele‐specific oligonucleotide PCR (ASO‐PCR) for minimal residual disease to enable early relapse ...
Chin‐Mu Hsu, Jui‐Feng Hsu, Jee‐Fu Huang, Yi‐Chang Liu   +3 more
wiley   +1 more source

Clonal Hematopoiesis of Indeterminate Potential After Radiation Therapy

International Journal of Radiation Oncology*Biology*Physics
Clonal hematopoiesis of indeterminate potential (CHIP) is a condition associated with increased risk of hematologic malignancies and cardiovascular diseases. Although radiation therapy has been identified as a risk factor for CHIP, specific radiation factors that influence the development of CHIP remain unclear.We identified 489 patients with cancer ...
Shelby A. Crants, Sydney S. Olson, Yajing Li, Cosmin A. Bejan, Caitlyn Vlasschaert, Taralynn M. Mack, Yash Pershad, Ashwin Kishtagari, Sarah C. Reed, Sarah Croessmann, Dan M. Roden, Travis J. Osterman, Eric T. Shinohara, Alexander G. Bick, Ben H. Park, Leo Y. Luo   +15 more
openaire   +2 more sources

Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury. [PDF]

Nat Med
Abstract Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential (CHIP) confers increased risk for several chronic diseases associated with aging.
Vlasschaert C, Robinson-Cohen C, Chen J, Akwo E, Parker AC, Silver SA, Bhatraju PK, Poisner H, Cao S, Jiang M, Wang Y, Niu A, Siew E, Van Amburg JC, Kramer HJ, Kottgen A, Franceschini N, Psaty BM, Tracy RP, Alonso A, Arking DE, Coresh J, Ballantyne CM, Boerwinkle E, Grams M, Zhang MZ, Kestenbaum B, Lanktree MB, Rauh MJ, Harris RC, Bick AG.   +30 more
europepmc   +4 more sources

Thrombotic, cardiovascular, and microvascular complications of myeloproliferative neoplasms and clonal hematopoiesis (CHIP): A narrative review [PDF]

The most common causes of morbidity and mortality in the myeloproliferative neoplasms (MPNs), with the exception of myelofibrosis, are venous and arterial thrombosis, as well as more recently discovered cardiovascular disease (CVD).
Mann, Douglas L, Schafer, Andrew I
core   +2 more sources