Results 111 to 120 of about 173,423,441 (192)

Causal association between clonal hematopoiesis indeterminate potential and cancer: a Mendelian randomization study

Experimental Biology and Medicine
Clonal hematopoiesis of indeterminate potential (CHIP) causes the expansion of mutated hematopoietic stem cells and produces immunophenotypically altered leukocytes, which induce a tumor-promoting inflammatory condition.
Juan Jin, Qian Pu, Chengrong Wu, Yu Lei, Yaxin Hu, Xiuju Yang, Jinghui Huang, Fangfang Wu, Li Xiao, Lei Yu   +9 more
doaj   +1 more source

Determinants of mosaic chromosomal alteration fitness

Nature Communications
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural ...
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick   +43 more
doaj   +1 more source

Clonal hematopoiesis of indeterminate potential and malignant neoplasms

Advances in Molecular Oncology
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with aging and is a risk factor of many diseases including malignant neoplasms (MNPs). It originates through somatic mutations in hematopoietic stem and/or progenitor cells, promotes development of hematological MNPs and underlies unfavorable prognosis in solid malignant tumors ...
V. E. Shevchenko, T. I. Kushnir, M. V. Gudkova, N. E. Arnotskaya   +3 more
openaire   +1 more source

Clonal Hematopoiesis of Indeterminate Potential [PDF]

, 2020
openaire   +1 more source

Pre-Infusion Host-Marrow Vulnerability in CD19- and BCMA-Directed CAR T-Cell Therapy: Clonal Hematopoiesis, Hematotoxicity, and Therapy-Related Myeloid Neoplasia

Cancer Management and Research
Yong Liu,1 Guiyu Su,2 Ruijin Li,3 Shuang Wang41Department of Hematology, the First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Oncology Medicine, the First Hospital of China Medical University ...
Liu Y, Su G, Li R, Wang S
doaj  

A non-conditioned bone marrow transplantation mouse model to study clonal hematopoiesis and myeloid malignancies

Experimental Hematology & Oncology
Clonal hematopoiesis of indeterminate potential (CHIP) is a condition where blood or bone marrow cells carry mutations associated with hematological malignancies.
Sofia Bentivegna, Marwa Almosailleakh, Lin-Pierre Zhao, Mikkel Bruhn Schuster, Sébastien Benquet, Alexander Balhuizen, Helga Fibiger Munch-Petersen, Lene Dissing Sjö, Mads Hald Andersen, Nicolas Dulphy, Bo Porse, Kirsten Grønbæk   +11 more
doaj   +1 more source

Hemothelium, Clonal Hematopoiesis of Indeterminate Potential, and Atherosclerosis [PDF]

Circulation, 2019
Abraham Aviv, Daniel Levy
openaire   +3 more sources

Clonal hematopoiesis of indeterminate potential (CHIP)-a pivotal contributor of aging and related disorders. [PDF]

Ann Transl Med
Dhenge A, Kulkarni R.
europepmc   +1 more source

Clonal hematopoiesis of indeterminate potential (CHIP), vascular somatic mutation, and cardiovascular disease: A narrative review. [PDF]

Vasc Med
Powell N, Cubbon RM, Bailey MA, Griffin KJ, Roberts L, Cheng C.   +5 more
europepmc   +1 more source

Clonal Hematopoiesis of Indeterminate Potential and Kidney Failure in CKD: An East Asian Cohort Study. [PDF]

Clin J Am Soc Nephrol
Kim M, An S, Ryu H, Sun C, An HY, Ryu G, Kim J, Kim Y, Kim SW, Kim YH, Jaiswal S, Koh Y, Oh KH.   +12 more
europepmc   +1 more source