Results 101 to 110 of about 173,423,441 (192)

Deciphering Clonal Hematopoiesis of Indeterminate Potential: Methods, Mechanisms, and Implications for Kidney Diseases. [PDF]

J Am Soc Nephrol
CKD afflicts over 10% of US adults, with its prevalence increasing sharply with age. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, genetically heterogeneous blood cell disorder characterized by the age-related clonal expansion of hematopoietic cells driven by leukemogenic somatic mutations yet without hematologic malignancy or ...
Yu Z, Vlasschaert C, Natarajan P.
europepmc   +3 more sources

The shadowlands of MDS: idiopathic cytopenias of undetermined significance (ICUS) and clonal hematopoiesis of indeterminate potential (CHIP)

, 2015
The WHO classification provides the best diagnostic approach to myelodysplastic syndromes (MDS). However, biologic and analytic limitations have emerged in the criteria currently adopted to establish the diagnosis and to classify MDS.
CAZZOLA, MARIO, MALCOVATI, LUCA
core   +1 more source

Clonal hematopoiesis of indeterminate potential-related epigenetic age acceleration correlates with clonal hematopoiesis of indeterminate potential clone size in patients with high morbidity

Haematologica, 2022
Jasper David Feldkamp, Valentin Max Vetter, Christopher Maximilian Arends, Tonio Johannes Lukas Lang, Lars Bullinger, Frederik Damm, Ilja Demuth, Mareike Frick   +7 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential as a Mediator of Radiation Toxicities [PDF]

Radiation toxicities are common, irreversible inflammatory consequences of radiation therapy (RT) for cancer for which the causes of inter-patient heterogeneity in latent time and severity remain elusive.
Hossack, Madison-Shira Alexis
core  

Loss of Y chromosome in Alzheimer’s patients co-occurs with somatic mutations beyond CHIP drivers

Life Science Alliance
Unknown driver mutations are enriched in Alzheimer’s patients with Y chromosome loss, suggesting LOY-driven clonal myeloid expansion may contribute to distinct disease-associated mutational profiles. Loss of Y chromosome (LOY) and clonal hematopoiesis of
Edyta Rychlicka-Buniowska, Daniil Sarkisyan, Monika Horbacz, Bożena Bruhn-Olszewska, Kinga Drężek-Chyła, Mikołaj Koszyński, Hanna Davies, Ulana Juhas, Magdalena Wójcik-Zalewska, Alicja Klich-Rączka, Lena Kilander, Martin Ingelsson, Karolina Bukowska-Strakova, Kazimierz Węglarczyk, Maciej Siedlar, Jarosław Baran, Janusz Ryś, Arkadiusz Piotrowski, Natalia Filipowicz, Jan P Dumanski   +19 more
doaj   +1 more source

Clonal hematopoiesis in immune-related and neurological disorders

Immunological Medicine
Clonal hematopoiesis (CH) results from somatic mutations in hematopoietic stem and progenitor cells. These mutations promote the expansion of mutant clones, which constitute a substantial proportion of peripheral blood cells.
Kotaro Ogawa, Tomohiro Yata, Yuto Hayashi, Tatsusada Okuno   +3 more
doaj   +1 more source

CHIPing away at immunity: the role of clonal hematopoiesis of indeterminate potential in bacterial pneumonia

The occurrence of clonal hematopoiesis of indeterminate potential (CHIP), in which advantageous somatic mutations result in the clonal expansion of blood cells, increases with age, as do an increased risk of mortality and detrimental outcomes associated ...
Elsa N. Bou Ghanem
core   +1 more source

Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study

Pharmacological Research
Clonal hematopoiesis of indeterminate potential (CHIP) is a prominent risk factor for atherosclerosis, but effective medications for CHIP-associated risk are still lacking.
Runzhen Chen, Jiannan Li, Shaodi Yan, Xiaoxiao Zhao, Jinying Zhou, Nan Li, Linghan Xue, Weida Liu, Peng Zhou, Chen Liu, Yi Chen, Yu Tan, Li Song, Hongbing Yan, Hanjun Zhao   +14 more
doaj   +1 more source

Emergency hematopoiesis in sepsis: A pathway to myeloid clonal expansion

HemaSphere, Volume 10, Issue 11, November 2026.
Olisaemeka Ogbue, Tariq Kewan, Serhan Unlu, Kartik Lakhotiya, Omar Mehkri, Rayna Ellison, Francois Fadell, Felipe de Almeida Sartori, Asfand Yar Cheema, Mark Orland, Arda Durmaz, Zachary Brady, Jennifer VanOudenhove, Abhay Singh, Valeria Visconte, Lourdes Mendez, David S. Bosler, Stephanie Halene, Mohammed J. Al‐Jaghbeer, Abhijit Duggal, Jaroslaw P. Maciejewski, Carmelo Gurnari   +21 more
wiley   +1 more source

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss [PDF]

Clonal hematopoiesis of indeterminate potential (CHIP) arises from aging-associated acquired mutations in hematopoietic progenitors, which display clonal expansion and produce phenotypically altered leukocytes.
Netea, Mihai G, Chavakis, Triantafyllos, Ballantyne, Christie M., Beck, James D, Barovic, Marko, North, Kari E, Beck, James D., Natarajan, Pradeep, Moss, Kevin, Divaris, Kimon, Lim, Jong-Hyung, Sen, Souvik, Korostoff, Jonathan M., Bing, Yu, Saha, Gundappa, Wang, Hui, Hajishengallis, George, Wu, Di, North, Kari E., Netea, Mihai G., Pan, Bohu, Giannakou, Danai, Korostoff, Jonathan M, Ballantyne, Christie M, Li, Xiaofei, Giannakou, D., Saha, G., Pan, B., Korostoff, J.M., Sen, S., Wang, H, Barovic, M., Ballantyne, C.M., Divaris, K., Lim, J.H.N., Natarajan, P., Hajishengallis, G., Wu, D., Netea, M.G., Moss, K., North, K.E., Chavakis, T., Beck, J.D., Bing, Y.   +43 more
core   +1 more source