Results 101 to 110 of about 6,041 (204)

Clonal Hematopoiesis and Incident Heart Failure With Preserved Ejection Fraction [PDF]

IMPORTANCE: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic stem cells with leukemogenic acquired genetic variants, is associated with incident heart failure (HF).
Ballantyne, Christie M, Bick, Alexander G, Carson, April P, Desai, Pinkal, Eaton, Charles B, Honigberg, Michael C, Kooperberg, Charles, Manson, JoAnn E, Natarajan, Pradeep, Raffield, Laura M, Reiner, Alexander P, Roberts, Mary B, Schuermans, Art, Shah, Amil M, Whitsel, Eric A, Yu, Bing   +15 more
core   +2 more sources

Deciphering Clonal Hematopoiesis of Indeterminate Potential

Journal of the American Society of Nephrology
CKD afflicts over 10% of US adults, with its prevalence increasing sharply with age. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, genetically heterogeneous blood cell disorder characterized by the age-related clonal expansion of hematopoietic cells driven by leukemogenic somatic mutations yet without hematologic malignancy or ...
Yu, Zhi, Vlasschaert, Caitlyn, Natarajan, Pradeep   +2 more
openaire   +4 more sources

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance

International Journal of Cancer, Volume 159, Issue 2, Page 410-422, 15 July 2026.
What's new? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz   +54 more
wiley   +1 more source

Clinical, Genetic, and Pathologic Variability in Myelodysplastic Syndromes and Precursor Conditions Across Race, Ethnicity, and Sex

American Journal of Hematology, Volume 101, Issue 6, Page 1407-1420, June 2026.
ABSTRACT The epidemiology of myelodysplastic syndromes/neoplasms (MDS) is challenging to define due to inconsistent reporting, complex diagnostic procedures, and evolving diagnostic criteria. Using the National MDS Natural History Study—a prospective cohort with centrally adjudicated histopathology and genetic variant review—we characterized the ...
Nancy Gillis, Christelle Colin‐Leitzinger, Yi‐Han Tang, Michael Otterstatter, Seth Sherman, Ling Zhang, Lynn C. Moscinski, Mary Ellen Walker, Jeffrey S. Painter, Gregory A. Abel, Tareq Al Baghdadi, H. Joachim Deeg, James M. Foran, Steven D. Gore, Alexandra M. Harrington, Steven H. Kroft, Jane Jijun Liu, Wael Saber, Shamsuddin Virani, Rafael Bejar, R. Coleman Lindsley, Eric Padron, Matthew J. Walter, Rami Komrokji, Amy E. DeZern, Mikkael A. Sekeres   +25 more
wiley   +1 more source

Clonal Hematopoiesis of Indeterminate Potential is Associated with Acute Kidney Injury

, 2023
Abstract Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms underlying this risk are largely unknown and to date no genetic mechanisms for AKI have been established. Clonal hematopoiesis of indeterminate potential (CHIP) is a recently recognized biological mechanism ...
Caitlyn Vlasschaert, Cassianne Robinson-Cohen, Bryan Kestenbaum, Samuel A. Silver, Jian-Chun Chen, Elvis Akwo, Pavan K Bhatraju, Ming-Zhi Zhang, Shirong Cao, Ming Jiang, Yinqiu Wang, Aolei Niu, Edward Siew, Holly J Kramer, Anna Kottgen, Nora Franceschini, Bruce M. Psaty, Russell P. Tracy, Alvaro Alonso, Dan E. Arking, Josef Coresh, Christie M Ballantyne, Eric Boerwinkle, Morgan Grams, Matthew B. Lanktree, Michael J. Rauh, Raymond C. Harris, Alexander G. Bick   +27 more
openaire   +2 more sources

Targeting Ikaros and Aiolos: Next‐Generation Cereblon E3 Ligase Modulators in MM

European Journal of Haematology, Volume 116, Issue 6, Page 697-708, June 2026.
The graphical abstract illustrates the mechanism of action of cereblon E3 ligase modulators (CELMoDs) in multiple myeloma, highlighting cereblon‐mediated degradation of IKZF1 and IKZF3. Compared with classical immunomodulatory drugs (IMiDs), CELMoDs induce deeper IKZF1/3 depletion, leading to more pronounced suppression of the IRF4–MYC survival axis ...
Maria Eugenia Alvaro, Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Diagnosing Systemic Mastocytosis: State of the Art

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 551-560, June 2026.
ABSTRACT With the advent of effective multikinase and selective tyrosine kinase inhibitors in systemic mastocytosis, diagnosing this rare disease has been critical to improving patient morbidity and mortality. This state‐of‐the‐art review interprets the international diagnostic criteria, including differences between the WHO 5th edition classification ...
Anton Rets, Tracy I. George
wiley   +1 more source

The effect of clonal hematopoiesis on long-term outcomes in patients undergoing coronary artery bypass grafting

BMC Medicine
Background Clonal hematopoiesis of indeterminate potential (CHIP), characterized by age-related somatic mutations in hematopoietic stem and progenitor cells, has been identified as a potential risk factor for cardiovascular events and mortality. However,
Zhiwei Zeng, Fangzhou Li, Shujie Gai, Runze Chen, Peng Wang, Juncheng Wang, Yuhui Yang, Jinhua Chen, Xingyi Zhang, Xueying Wang, Yi Han, Chuxiang Lei, Xi Li, Hanning Liu, Zhe Zheng   +14 more
doaj   +1 more source

Clonal hematopoiesis in patients with cancer and cancer survivors: From clonal burden to cardiovascular diseases

Cancer, Volume 132, Issue 10, 15 May 2026.
ABSTRACT Over the past decade, clonal hematopoiesis (CH) has gained substantial attention as a prevalent, age‐associated phenomenon with major implications for hematologic malignancy, cardiovascular disease, and mortality. CH arises from the clonal expansion of hematopoietic stem cells and progenitor cells harboring somatic mutations, most commonly in ...
Christian H. Nenninger, Keith Anderson, Jenaro Espitia‐Corredor, Brittany Echevarria, Vertica Agnihotri, Zhao Wang, Scott R. Goldsmith, June‐Wha Rhee   +7 more
wiley   +1 more source

Novel BRAF fusion in Erdheim–Chester disease with pulmonary manifestations: Importance of RNA‐based testing and response to MEK inhibition

Histopathology, EarlyView.
Igor Odintsov, Henry D. Tazelaar, Jerry C. Lee, Lloyd E. Damon, Walter Patrick Devine, Kirk D. Jones   +5 more
wiley   +1 more source