Results 71 to 80 of about 173,423,441 (192)

Expansion of fibroblast-like cells may explain the CANTOS meta-analysis findings for patients with clonal hematopoiesis. [PDF]

, 2023
Clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for cardiovascular disease. Neutralization of the cytokine IL-1β (as in the CANTOS clinical trial) resulted in a greater reduction in adverse cardiovascular events in patients with ...

core   +2 more sources

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation

Cell Reports, 2019
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is caused by recurrent somatic mutations leading to clonal blood cell expansion. However, direct evidence of the fitness of CHIP-mutated human hematopoietic stem cells (HSCs) in blood ...
Christina A. Ortmann, Lena Dorsheimer, Khalil Abou-El-Ardat, Jennifer Hoffrichter, Birgit Assmus, Halvard Bonig, Anica Scholz, Heike Pfeifer, Hans Martin, Tobias Schmid, Bernhard Brüne, Sebastian Scheich, Björn Steffen, Julia Riemann, Stella Hermann, Alexandra Dukat, Gesine Bug, Christian H. Brandts, Sebastian Wagner, Hubert Serve, Michael A. Rieger   +20 more
doaj   +1 more source

Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19

Frontiers in Immunology, 2022
Clonal hematopoiesis of indeterminate potential (CHIP) leads to higher mortality, carries a cardiovascular risk and alters inflammation. All three aspects harbor overlaps with the clinical manifestation of COVID-19.
Judith Schenz, Katharina Rump, Katharina Rump, Benedikt Hermann Siegler, Inga Hemmerling, Tim Rahmel, Jan N. Thon, Hartmuth Nowak, Hartmuth Nowak, Dania Fischer, Anna Hafner, Lucas Tichy, Katharina Bomans, Manja Meggendorfer, Björn Koos, Björn Koos, Thilo von Groote, Thilo von Groote, Alexander Zarbock, Alexander Zarbock, Mascha O. Fiedler, Johanna Zemva, Jan Larmann, Uta Merle, Michael Adamzik, Michael Adamzik, Carsten Müller-Tidow, Torsten Haferlach, Florian Leuschner, Markus A. Weigand, Markus A. Weigand   +30 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Health

Cardiology Clinics
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon in which somatic mutations lead to clonal expansion of hematopoietic stem cells without the development of hematologic abnormalities. A growing body of literature demonstrates an association between CHIP and cardiovascular disease.
Raddatz, Michael A., Pershad, Yash, Parker, Alyssa C., Bick, Alexander G.   +3 more
openaire   +2 more sources

Liquid biopsy across cancers: Integrating circulating biomarkers, tumor biology, artificial intelligence, and clinical translation

Interdisciplinary Medicine, EarlyView.
Liquid biopsy uses non‐invasive sampling of blood or body fluids to isolate circulating analytes, including circulating tumor DNA, circulating tumor cells, extracellular vesicles, and RNA. These are analyzed using next‐generation sequencing, qPCR, and proteomics to inform cancer detection, monitoring, and characterization. Figure created with BioRender.
Jaswinder Singh, Manjeet Kumar, Kajal Kamra   +2 more
wiley   +1 more source

JAK2 Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?

Movement Disorders Clinical Practice, EarlyView.
Abstract Background JAK2 variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well‐recognized neurological occurrence in this context ...
Elena Ardila Jurado, Koustubh Bavdhankar, Divyani Garg, Francesca Magrinelli, Huw R. Morris, Kailash P. Bhatia   +5 more
wiley   +1 more source

Shared and Distinguishing Features of Late‐Onset Rheumatic Diseases Fulfilling Polymyalgia Rheumatica Classification Criteria

Arthritis &Rheumatology, EarlyView.
Kerem Abacar, Ala Altaie, Andrew Barr, Sarah L. Mackie, Kulveer Mankia, Dennis McGonagle   +5 more
wiley   +1 more source

Transcriptomic profiling of calcified aortic valves in clonal hematopoiesis of indeterminate potential carriers

Scientific Reports, 2022
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the presence of clones of mutated blood cells without overt blood diseases.
Francesco Vieceli Dalla Sega, Domenico Palumbo, Francesca Fortini, Ylenia D’Agostino, Paolo Cimaglia, Luisa Marracino, Paolo Severi, Oriana Strianese, Roberta Tarallo, Giovanni Nassa, Giorgio Giurato, Giovanni Pecoraro, Serena Caglioni, Elisa Mikus, Alberto Albertini, Gianluca Campo, Roberto Ferrari, Paola Rizzo, Alessandro Weisz, Francesca Rizzo   +19 more
doaj   +1 more source

Machine Learning‐Derived Immune Gene Signature Predicts Prognosis and Therapeutic Vulnerabilities in Multiple Myeloma

Cancer Science, EarlyView.
An immune‐related 12‐gene signature developed through integrative machine learning stratified overall survival across multiple myeloma cohorts and remained independently associated with outcome. Single‐cell, somatic mutation, and transcriptome‐based drug‐response analyses further linked the signature to multicellular bone marrow context, distinct ...
Kai Wang, Chenfei Zhao, Jingru Shi, Shiwei Liu, Yi Chen, Jujuan Wang, Zhengxu Sun, Sanmei Wang, Lei Fan, Jin Fan, Xiaoyan Qu   +10 more
wiley   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source