Results 51 to 60 of about 173,423,441 (192)

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, EarlyView.
Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R. Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation [PDF]

, 2019
Clonal hematopoiesis of indeterminate potential (CHIP) is a recently identified process where older patients accumulate distinct subclones defined by recurring somatic mutations in hematopoietic stem cells.
Michael B. Bonsall (39581), Philip K Maini, Alexander R A Anderson, Alexander R. A. Anderson (243113), Derek S. Park (6640274), Michael B Bonsall, H Leighton Grimes, David E. Muench (4245634), Philip K. Maini (108832), David E Muench, Pearlie K. Epling-Burnette (348865), Derek S Park, H. Leighton Grimes (259982), Afua A. Akuffo (6640277), Pearlie K Epling-Burnette, Afua A Akuffo   +15 more
core   +1 more source

Inflammatory reprogramming of the solid tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes

Cell Reports Medicine
Summary: Clonal hematopoiesis (CH)—the expansion of somatically mutated hematopoietic cells—is common in solid cancers. CH is associated with systemic inflammation, but its impact on tumor biology is underexplored.
Marco M. Buttigieg, Caitlyn Vlasschaert, Alexander G. Bick, Robert J. Vanner, Michael J. Rauh   +4 more
doaj   +1 more source

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source

Clonal hematopoiesis of indeterminate potential is rare in pediatric patients undergoing autologous stem cell transplantation. [PDF]

Clonal hematopoiesis of indeterminate potential (CHIP) describes recurrent somatic gene mutations in the blood of healthy individuals, associated with higher risk for hematological malignancies and higher all-cause mortality by cardiovascular disease ...
Zweier, Christiane, Kartal-Kaess, Mutlu, Pabst, Thomas, Bacher, Vera, Joncourt, Raphael, Kuehni, Claudia E, Roessler, Jochen, Karow, Axel, Porret, Naomi Azur   +8 more
core   +1 more source

Myelodysplasia syndrome, clonal hematopoiesis and cardiovascular disease [PDF]

, 2021
The development of myelodysplasia syndromes (MDS) is multiphasic and can be driven by a plethora of genetic mutations and/or abnormalities. MDS is characterized by a hematopoietic differentiation block, evidenced by increased immature hematopoietic cells,
Herold, MJ, Veiga, CB, Murphy, AJ, Dragoljevic, D, Lawrence, EM   +4 more
core   +1 more source

Cancer patients with clonal hematopoiesis die from primary malignancy or comorbidities despite higher rates of transformation to myeloid neoplasms

Cancer Medicine
Background The occurrence of somatic mutations in patients with no evidence of hematological disorders is called clonal hematopoiesis (CH). CH, whose subtypes include CH of indeterminate potential and clonal cytopenia of undetermined significance, has ...
Kelly S. Chien, Faustine Ong, Kunhwa Kim, Ziyi Li, Rashmi Kanagal‐Shamanna, Courtney D. DiNardo, Koichi Takahashi, Guillermo Montalban‐Bravo, Danielle Hammond, Koji Sasaki, Sherry A. Pierce, Hagop M. Kantarjian, Guillermo Garcia‐Manero   +12 more
doaj   +1 more source

Clinical Significance of Clonal Hematopoiesis of Indeterminate Potential in Hematology and Cardiovascular Disease

Diagnostics, 2022
Liquid profiling uses circulating tumor DNA (ctDNA) for minimal invasive tumor mutational profiling from peripheral blood. The presence of somatic mutations in peripheral blood cells without further evidence of a hematologic neoplasm defines clonal ...
Gregor Hoermann
doaj   +1 more source

A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Natural killer (NK) cell neoplasms span indolent to highly aggressive entities, and flow cytometric immunophenotyping is central to their detection and classification. However, distinguishing reactive from neoplastic NK cell expansions can be challenging because NK cells lack somatically recombined antigen receptors, and reactive states may ...
Aaron J. Wilk, Afshin Shameli, Erik Ames, Jonathan R. Fromm, Bartosz Grzywacz, Min Shi, Sindhu Cherian, Jean Oak   +7 more
wiley   +1 more source

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

, 2015
Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human aging.
Lindsley, R Coleman, Hasserjian, Robert P, Jaiswal, Siddhartha, Bejar, Rafael, Ebert, Benjamin L, Steensma, David P, Sekeres, Mikkael A   +6 more
core   +1 more source