Results 51 to 60 of about 6,041 (204)

Hematopoiesis and T-cell specification as a model developmental system [PDF]

, 2016
The pathway to generate T cells from hematopoietic stem cells guides progenitors through a succession of fate choices while balancing differentiation progression against proliferation, stage to stage.
Kueh, Hao Yuan, Rothenberg, Ellen V., Yui, Mary A., Zhang, Jingli A.   +3 more
core   +1 more source

Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men. [PDF]

, 2023
Little is known regarding the potential relationship between clonal hematopoiesis (CH) of indeterminate potential (CHIP), which is the expansion of hematopoietic stem cells with somatic mutations, and risk of prostate cancer, the fifth leading cause of ...
Albanes, D, Berndt, SI, Catalona, WJ, Chanock, S, Conti, DV, Dadaev, T, Darst, BF, de Smith, AJ, Doheny, KF, Eeles, RA, Gapstur, SM, Giles, GG, Gnanapragasam, V, Haiman, CA, Hetrick, KN, Huff, C, Kim, T, Kote-Jarai, Z, MacInnis, RJ, Milne, RL, Mucci, LA, Nead, KT, Nguyen-Dumont, T, Pomerantz, MM, Pooler, L, Saunders, E, Schmidt, JA, Sheng, X, Southey, MC, Stevens, V, Stopsack, KH, Wan, P, Wang, A, Weinstein, SJ, Wiklund, F, Xia, LY, Xu, K, Xu, Y, Yu, Y   +38 more
core   +1 more source

Clinical Significance of Clonal Hematopoiesis of Indeterminate Potential in Hematology and Cardiovascular Disease

Diagnostics, 2022
Liquid profiling uses circulating tumor DNA (ctDNA) for minimal invasive tumor mutational profiling from peripheral blood. The presence of somatic mutations in peripheral blood cells without further evidence of a hematologic neoplasm defines clonal ...
Gregor Hoermann
doaj   +1 more source

Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential [PDF]

, 2022
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies.
de Las Fuentes, Lisa, et al,, Gu, C Charles, Nakao, Tetsushi   +3 more
core   +1 more source

Clinical consequences of clonal hematopoiesis of indeterminate potential [PDF]

Blood Advances, 2018
Abstract Clonally restricted hematopoiesis is a common aging-associated biological state that predisposes to subsequent development of a hematological malignancy or cardiovascular death. Clonal expansion driven by leukemia-associated somatic mutations, such as DNMT3A, ASXL1, or TET2, is best characterized, but oligoclonality can also ...
openaire   +4 more sources

A framework for the molecular identification of CHIP for clinical research

HGG Advances
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with many diseases of aging. Large research initiatives are needed to develop clinical guidelines for the management of individuals with CHIP and their risk of disease. However,
Philip Harraka, Robert L. O’Reilly, Jared Burke, Paul Yeh, Kerryn Howlett, Kiarash Behrouzfar, Daniele Belluoccio, Amanda Rewse, Brigid M. Lynch, Kristen J. Bubb, Stephen J. Nicholls, Roger L. Milne, Melissa C. Southey   +12 more
doaj   +1 more source

Long Telomeric Repeat-Containing RNA (TERRA): Biological Functions and Challenges in Vascular Aging and Disease

Biomedicines, 2023
Telomere dysfunction is implicated in vascular aging and shorter leucocyte telomeres are associated with an increased risk of atherosclerosis, myocardial infarction, and heart failure.
Paola Canale, Jonica Campolo, Andrea Borghini, Maria Grazia Andreassi   +3 more
doaj   +1 more source

High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia [PDF]

, 1998
A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV‐8) was conducted in Sardinia, one of the world's highest incidence areas for classic Kaposi's sarcoma (KS). Prevalence of antibodies to HHV‐8 sVCA
Angeloni, Antonio, Cerimele, Decio, Cottoni, Francesca Maria Giovanna, Faggioni, Alberto, Heston, Lee, Lin, Su-Fang, Masala, Maria Vittoria, Miller, George, Rigsby, Michael, Sirianni, Maria Caterina, Sun, Ren, Uccini, Stefania   +11 more
core   +1 more source

Obesity and Clonal Hematopoiesis of Indeterminate Potential: Allies in Cardiovascular Diseases and Malignancies

Life, 2023
The clonal hematopoiesis of indeterminate potential (CHIP) is a term used to describe individuals who have detectable somatic mutations in genes commonly found in individuals with hematologic cancers but without any apparent evidence of such conditions ...
Luka Komic, Marko Kumric, Hrvoje Urlic, Azer Rizikalo, Marko Grahovac, Jelena Kelam, Marion Tomicic, Doris Rusic, Tina Ticinovic Kurir, Josko Bozic   +9 more
doaj   +1 more source

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source