Results 11 to 20 of about 143,820 (254)

CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Hematopoietic stem cells (HSCs) ensure the coordinated and balanced production of all hematopoietic cell types throughout life. Aging is associated with a gradual decline of the self-renewal and regenerative potential of HSCs and with the development of
Ugo Testa, Germana Castelli , Elvira Pelosi   +2 more
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Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment

Blood Cancer Journal, 2023
Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones caused by the acquisition of somatic point mutations or mosaic chromosomal alterations (mCAs).
Kelly von Beck, Troy von Beck, P. Brent Ferrell, Alexander G. Bick, Ashwin Kishtagari   +4 more
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Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Nature Communications, 2019
Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis ...
Sisi Chen, Qiang Wang, Hao Yu, Maegan L. Capitano, Sasidhar Vemula, Sarah C. Nabinger, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Zhuangzhuang Geng, Aidan Fahey, Danielle Henley, Stephen Z. Liu, Sergio Barajas, Wenjie Cai, Eric R. Wolf, Baskar Ramdas, Zhigang Cai, Hongyu Gao, Na Luo, Yang Sun, Terrence N. Wong, Daniel C. Link, Yunlong Liu, H. Scott Boswell, Lindsey D. Mayo, Gang Huang, Reuben Kapur, Mervin C. Yoder, Hal E. Broxmeyer, Zhonghua Gao, Yan Liu   +31 more
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Genetics of smoking and risk of clonal hematopoiesis

Scientific Reports, 2022
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing expanded somatic mutations have been linked to both oncologic and non-oncologic clinical ...
Michael G. Levin, Tetsushi Nakao, Seyedeh M. Zekavat, Satoshi Koyama, Alexander G. Bick, Abhishek Niroula, Benjamin Ebert, Scott M. Damrauer, Pradeep Natarajan   +8 more
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Clonal hematopoiesis and thrombosis risk—what are research and clinical gaps? [PDF]

Research and Practice in Thrombosis and Haemostasis
Clonal hematopoiesis (CH) is characterized by the clonal expansion of hematopoietic stem cells driven by somatic mutations that confer a survival or proliferative advantage.
Cornelia Englisch, Cihan Ay
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Cardio-Oncological Sequelae of Autologous Stem Cell Transplantation [PDF]

JACC: Advances
Autologous hematopoietic stem cell transplantation is a major milestone in modern oncohematological therapies; however, both in the peritransplant and post-transplant phase, the incidence of cardiovascular (CV) events is markedly higher than in the ...
Zsófia Sándor, MD, Zoltán V. Varga, MD, PhD, Tamás G. Gergely, MD, PhD, Laura Horváth, MD, PhD, Tamás Masszi, MD, PhD, Zsófia D. Drobni, MD, PhD, José J. Fuster, MD, PhD, Zoltán Pozsonyi, MD, PhD   +7 more
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The OmniAge compendium of aging omic biomarkers links mitotic clocks to clonal hematopoiesis and causality [PDF]

Nature Communications
Interest in aging ‘omic’ biomarkers has grown due to their ability to quantify biological age. Most of these biomarkers have been derived in blood and fall into many diverse categories, yet relatively little is known about their correlative patterns ...
Zhaozhen Du, Yunchao Ling, Huige Tong, Xiaolong Guo, Andrew E. Teschendorff   +4 more
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Common in atherogenesis and carcinogenesis: clonal hematopoiesis

Российский кардиологический журнал, 2023
Clonal hematopoiesis is a common age-dependent state accompanied by the expansion of mutant hematopoietic stem cells as a result of somatic mutations and is associated with a high risk of hematopoietic neoplasms and cardiovascular diseases.
A. A. Sleptsov, M. S. Nazarenko, V. Р. Puzyrev   +2 more
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Clonal hematopoiesis in cardiovascular disease and therapeutic implications [PDF]

, 2022
Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to hematopoietic stem cells and the outgrowth of clones of blood cells.
Tall, Alan R., Fuster, Jose J., Tall, Alan R, Jose J. Fuster, Alan R. Tall   +4 more
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Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease

Nature Communications, 2022
Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs.
M d Mesbah Uddin, Ngoc Quynh H. Nguyen, Bing Yu, Jennifer A. Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S. Weinstock, Michael C. Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K. Griffin, Varuna Chander, Richard A. Gibbs, Jerome I. Rotter, Chunyu Liu, Andrea A. Baccarelli, Daniel I. Chasman, Eric A. Whitsel, Douglas P. Kiel, Joanne M. Murabito, Eric Boerwinkle, Benjamin L. Ebert, Siddhartha Jaiswal, James S. Floyd, Alexander G. Bick, Christie M. Ballantyne, Bruce M. Psaty, Pradeep Natarajan, Karen N. Conneely   +31 more
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