Results 11 to 20 of about 41,259 (301)

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence [PDF]

New England Journal of Medicine, 2014
Background Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent.
Bakhoum, Samuel F., Chambert, Kimberly, Fromer, Menachem, Gabriel, Stacey B., Genovese, Giulio, Gronberg, Henrik, Handsaker, Robert E., Hoglund, Martin, Hultman, Christina M., Kahler, Anna K., Landen, Mikael, Lander, Eric S., Lehmann, Soren, Lindberg, Johan, McCarroll, Steven A., Mick, Eran, Moran, Jennifer L., Neale, Benjamin M., Purcell, Shaun M., Rose, Samuel A., Sklar, Pamela, Sullivan, Patrick F., Svantesson, Oscar   +22 more
core   +4 more sources

CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Hematopoietic stem cells (HSCs) ensure the coordinated and balanced production of all hematopoietic cell types throughout life. Aging is associated with a gradual decline of the self-renewal and regenerative potential of HSCs and with the development of
Ugo Testa, Germana Castelli , Elvira Pelosi   +2 more
doaj   +1 more source

Clonal hematopoiesis and hematological malignancy

The Journal of Clinical Investigation
Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny driven by somatic mutations in leukemia-associated genes, is a common phenomenon that rises in prevalence with advancing age to affect most people older than 70 years.
William G. Dunn, Matthew A. McLoughlin, George S. Vassiliou   +2 more
doaj   +3 more sources

Clonal hematopoiesis [PDF]

Seminars in Hematology, 2017
Cancer results from multistep pathogenesis, yet the pre-malignant states that precede the development of many hematologic malignancies have been difficult to identify. Recent genomic studies of blood DNA from tens of thousands of people have revealed the presence of remarkably common, age-associated somatic mutations in genes associated with ...
Max, Jan, Benjamin L, Ebert, Siddhartha, Jaiswal   +2 more
openaire   +2 more sources

Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment

Blood Cancer Journal, 2023
Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones caused by the acquisition of somatic point mutations or mosaic chromosomal alterations (mCAs).
Kelly von Beck, Troy von Beck, P. Brent Ferrell, Alexander G. Bick, Ashwin Kishtagari   +4 more
doaj   +1 more source

Bone marrow senescence and the microenvironment of hematological malignancies [PDF]

, 2020
Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been ...
Bowles, Kristian M., Hellmich, Charlotte, Moore, Jamie A., Rushworth, Stuart A.   +3 more
core   +1 more source

Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease

Nature Communications, 2022
Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs.
M d Mesbah Uddin, Ngoc Quynh H. Nguyen, Bing Yu, Jennifer A. Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S. Weinstock, Michael C. Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K. Griffin, Varuna Chander, Richard A. Gibbs, Jerome I. Rotter, Chunyu Liu, Andrea A. Baccarelli, Daniel I. Chasman, Eric A. Whitsel, Douglas P. Kiel, Joanne M. Murabito, Eric Boerwinkle, Benjamin L. Ebert, Siddhartha Jaiswal, James S. Floyd, Alexander G. Bick, Christie M. Ballantyne, Bruce M. Psaty, Pradeep Natarajan, Karen N. Conneely   +31 more
doaj   +1 more source

Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis

Acta Pharmaceutica Sinica B, 2022
Aging-elevated DNMT3A R882H-driven clonal hematopoiesis (CH) is a risk factor for myeloid malignancies remission and overall survival. Although some studies were conducted to investigate this phenomenon, the exact mechanism is still under debate. In this
Min Liao, Ruiqing Chen, Yang Yang, Hanqing He, Liqian Xu, Yuxuan Jiang, Zhenxing Guo, Wei He, Hong Jiang, Jianwei Wang   +9 more
doaj   +1 more source

Utility of plasma cell-free DNA for de novo detection and quantification of clonal hematopoiesis

Haematologica, 2021
Although cell-free DNA (cfDNA) tests have emerged as a potential non-invasive alternative to bone marrow biopsies for monitoring clonal hematopoiesis in hematologic diseases, whether commercial cfDNA assays can be implemented for the detection and ...
Fernanda Gutierrez-Rodrigues, Isabel Beerman, Emma M. Groarke, Bhavisha A. Patel, Nina Spitofsky, Laura W. Dillon, Diego Quinones Raffo, Christopher S. Hourigan, Sachiko Kajigaya, Luigi Ferrucci, Neal S. Young   +10 more
doaj   +1 more source

Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic Neoplasm

Life, 2022
Hematopoietic stem cell aging, through the acquisition of somatic mutations, gives rise to clonal hematopoiesis (CH). While a high prevalence of CH has been described in otherwise healthy older adults, CH confers an increased risk of both hematologic and
Charles Gaulin, Katalin Kelemen, Cecilia Arana Yi   +2 more
doaj   +1 more source