Results 11 to 20 of about 187,082 (288)

Clonal evolution in cancer [PDF]

Nature, 2012
Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it
Mel, Greaves, Carlo C, Maley
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Clonal evolution in leukemia [PDF]

Nature Medicine, 2017
Human leukemias are liquid malignancies characterized by diffuse infiltration of the bone marrow by transformed hematopoietic progenitors. The accessibility of tumor cells obtained from peripheral blood or through bone marrow aspirates, together with recent advances in cancer genomics and single-cell molecular analysis, have facilitated the study of ...
Ferrando, Adolfo A, López-Otín, Carlos
openaire   +5 more sources

Clonal Evolution of High-Risk Chronic Lymphocytic Leukemia: A Contemporary Perspective

Frontiers in Oncology, 2021
Clonal evolution represents the natural process through which cancer cells continuously search for phenotypic advantages that enable them to develop and expand within microenvironmental constraints. In chronic lymphocytic leukemia (CLL), clonal evolution
Marwan Kwok, Marwan Kwok, Catherine J. Wu, Catherine J. Wu, Catherine J. Wu, Catherine J. Wu   +5 more
doaj   +1 more source

Whole exome and transcriptome sequencing reveal clonal evolution and exhibit immune-related features in metastatic colorectal tumors

Cell Death Discovery, 2021
Liver is the most common site where metastatic lesions of colorectal cancer (CRC) arise. Although researches have shown mutations in driver genes, copy number variations (CNV) and alterations in relevant signaling pathways promoted the tumor evolution ...
Chunxue Li, Juan Xu, Xiangfeng Wang, Chao Zhang, Zicheng Yu, Jiucheng Liu, Zaixian Tai, Ziwen Luo, Xin Yi, Zhaoyang Zhong   +9 more
doaj   +1 more source

Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming

Molecular Cancer, 2022
Background Multiple myeloma (MM) is a heterogeneous disease with different patterns of clonal evolution and a complex tumor microenvironment, representing a challenge for clinicians and pathologists to understand and dissect the contribution and impact ...
Yuanzheng Liang, Haiyan He, Weida Wang, Henan Wang, Shaowen Mo, Ruiying Fu, Xindi Liu, Qiong Song, Zhongjun Xia, Liang Wang   +9 more
doaj   +1 more source

Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

Frontiers in Immunology, 2023
IntroductionThe malignant transformation leading to a maturation arrest in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) occurs early in B-cell development, in a pro-B or pre-B cell, when somatic recombination of variable (V), diversity (D ...
Franziska Darzentas, Monika Szczepanowski, Michaela Kotrová, Alina Hartmann, Alina Hartmann, Alina Hartmann, Thomas Beder, Thomas Beder, Nicola Gökbuget, Stefan Schwartz, Stefan Schwartz, Lorenz Bastian, Lorenz Bastian, Lorenz Bastian, Claudia Dorothea Baldus, Claudia Dorothea Baldus, Claudia Dorothea Baldus, Karol Pál, Nikos Darzentas, Monika Brüggemann, Monika Brüggemann, Monika Brüggemann   +21 more
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Clonal evolution of leukemia from G6PD studies [PDF]

Haematologica, 2023
Tal Bacharach, Liran I. Shlush
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Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic Neoplasm

Life, 2022
Hematopoietic stem cell aging, through the acquisition of somatic mutations, gives rise to clonal hematopoiesis (CH). While a high prevalence of CH has been described in otherwise healthy older adults, CH confers an increased risk of both hematologic and
Charles Gaulin, Katalin Kelemen, Cecilia Arana Yi   +2 more
doaj   +1 more source

A scalable model for simulating multi-round antibody evolution and benchmarking of clonal tree reconstruction methods

Frontiers in Immunology, 2022
Affinity maturation (AM) of B cells through somatic hypermutations (SHMs) enables the immune system to evolve to recognize diverse pathogens. The accumulation of SHMs leads to the formation of clonal lineages of antibody-secreting b cells that have ...
Chao Zhang, Andrey V. Bzikadze, Yana Safonova, Siavash Mirarab   +3 more
doaj   +1 more source

Organellar inheritance in the green lineage: insights from Ostreococcus tauri [PDF]

, 2013
Along the green lineage (Chlorophyta and Streptophyta), mitochondria and chloroplast are mainly uniparentally transmitted and their evolution is thus clonal. The mode of organellar inheritance in their ancestor is less certain.
Adam Eyre-Walker, Baur, Birky, Bonen, Boynton, Bruen, Correns, De Clerck, Derelle, Duret, Grimsley, Guindon, Gwenael Piganeau, Hasegawa, Hill, Hill, Houliston, Hua, Huang, Hurst, Hutson, Jancek, Kurtz, Larkin, Lewis, Lewontin, Li, MacAlpine, Marin, Marshall, Maréchal, Maynard Smith, McVean, Miyamura, Muller, Nei, Ness, Olson, Piganeau, Posada, Posada, R Development Core Team, Robbens, Rodríguez-Ezpeleta, Romain Blanc-Mathieu, Sager, Sager, Sager, Simpson, Sophie Sanchez-Ferandin, Städler, Sun, Sung, Swofford, Tamura, Tamura, Tsai   +56 more
core   +2 more sources