Results 31 to 40 of about 187,082 (288)
Clonal evolution in primary 5q- syndrome [PDF]
Cancer, 1992 Primary 5q-syndrome is a type of myelodysplastic syndrome characterized by refractory anemia, thrombocytosis, and hypolobulated megakaryocytes. The risk of leukemic transformation is low. A case of 5q- syndrome that occurred in a 42-year-old woman and was complicated by leukemic transformation 7 years after the initial diagnosis is reported.
Wong, KF, Chan, JKC, Chu, YC, Kwong, YL
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IAMBEE : a web-service for the identification of adaptive pathways from parallel evolved clonal populations [PDF]
, 2019 IAMBEE is a web server designed for the Identification of Adaptive Mutations in Bacterial Evolution Experiments (IAMBEE). Input data consist of genotype information obtained from independently evolved clonal populations or strains that show the same ...
De Maeyer, Dries +6 more
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Visualizing Clonal Evolution in Cancer [PDF]
Molecular Cell, 2016 Rapid and inexpensive single-cell sequencing is driving new visualizations of cancer instability and evolution. Krzywinski discusses how to present clone evolution plots in order to visualize temporal, phylogenetic, and spatial aspects of a tumor in a single static image.
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Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
Nature Communications, 2019 When examining the evolution of treatment resistance in breast cancer, perceived genomic changes may be due to clonal evolution or heterogeneous tumors. Here, the authors show that apparent clonal change can in fact be due to pre-treatment heterogeneity,
Jennifer L. Caswell-Jin +19 more
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BMC Genomics, 2021 Background All diseases containing genetic material undergo genetic evolution and give rise to heterogeneity including cancer and infection. Although these illnesses are biologically very different, the ability for phylogenetic retrodiction based on the ...
Filippo Utro +3 more
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Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]
, 2013 To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare.
Neher, Richard A.
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Leukemia Research Reports, 2019 The natural history of primary hypereosinophilia remains poorly defined, given the underlying disease heterogeneity. Recently, targeted NGS helps to establish clonality in a subset of patients with hypereosinophilia.
Meiyu Chen +5 more
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The clonal origin and clonal evolution of epithelial tumours
International Journal of Experimental Pathology, 2000 While the origin of tumours, whether from one cell or many, has been a source of fascination for experimental oncologists for some time, in recent years there has been a veritable explosion of information about the clonal architecture of tumours and their antecedents, stimulated, in the main, by the ready accessibility of new molecular techniques ...
S B, Garcia, M, Novelli, N A, Wright
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Predicting lung cancer recurrence from circulating tumour DNA. Commentary on 'Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution' [PDF]
, 2017 No abstract ...
Daniel J Murphy +11 more
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Polyclonal evolution of Fanconi anemia to MDS and AML revealed at single cell resolution
Experimental Hematology & Oncology, 2022 Background Fanconi anemia (FA) is a rare disease of bone marrow failure. FA patients are prone to develop myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
Lixian Chang +13 more
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