Results 41 to 50 of about 187,082 (288)
Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine [PDF]
, 2013 Streptococcus pneumoniae causes invasive infections, primarily at the extremes of life. A seven-valent conjugate vaccine (PCV7) is used to protect against invasive pneumococcal disease in children.
Chan, Jacqueline +10 more
core +2 more sources
Clonal Evolution of Autoreactive Germinal Centers [PDF]
Cell, 2017 Germinal centers (GCs) are the primary sites of clonal B cell expansion and affinity maturation, directing the production of high-affinity antibodies. This response is a central driver of pathogenesis in autoimmune diseases, such as systemic lupus erythematosus (SLE), but the natural history of autoreactive GCs remains unclear. Here, we present a novel
Degn SE +11 more
openaire +3 more sources
, 2014 We discuss a cancer hallmark network framework for modelling genome-sequencing data to predict cancer clonal evolution and associated clinical phenotypes.
Masoudi-Nejad, Ali +5 more
core +1 more source
Spatiotemporal co-existence of two Mycobacterium ulcerans clonal complexes in the Offin River Valley of Ghana [PDF]
, 2016 In recent years, comparative genome sequence analysis of African Mycobacterium ulcerans strains isolated from Buruli ulcer (BU) lesion specimen has revealed a very limited genetic diversity of closely related isolates and a striking association between ...
Aboagye, Samuel +11 more
core +9 more sources
Spatial constraints govern competition of mutant clones in human epidermis
Nature Communications, 2017 Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with ...
M. D. Lynch +6 more
doaj +1 more source
Deep learning for sensitive detection of Helicobacter Pylori in gastric biopsies
BMC Gastroenterology, 2020 Background Helicobacter pylori, a 2 × 1 μm spiral-shaped bacterium, is the most common risk factor for gastric cancer worldwide. Clinically, patients presenting with symptoms of gastritis, routinely undergo gastric biopsies.
Sebastian Klein +7 more
doaj +1 more source
Evolution of Resistance During Clonal Expansion [PDF]
Genetics, 2006 Abstract Acquired drug resistance is a major limitation for cancer therapy. Often, one genetic alteration suffices to confer resistance to an otherwise successful therapy. However, little is known about the dynamics of the emergence of resistant tumor cells.
Yoh, Iwasa +2 more
openaire +2 more sources
The asexual genome of Drosophila
, 2017 The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments ...
Lässig, Michael +2 more
core +1 more source
Mass concentration in a nonlocal model of clonal selection [PDF]
, 2016 Self-renewal is a constitutive property of stem cells. Testing the cancer stem cell hypothesis requires investigation of the impact of self-renewal on cancer expansion. To understand better this impact, we propose a mathematical model describing dynamics
Busse, Jan-Erik +2 more
core +1 more source
Experimental evolution reveals high insecticide tolerance in Daphnia inhabiting farmland ponds [PDF]
, 2015 Exposure of nontarget populations to agricultural chemicals is an important aspect of global change. We quantified the capacity of natural Daphnia magna populations to locally adapt to insecticide exposure through a selection experiment involving ...
Agra +36 more
core +2 more sources