Results 51 to 60 of about 187,082 (288)

Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models

Computational and Structural Biotechnology Journal, 2020
Genetic heterogeneity within a tumor arises by clonal evolution, and patients with highly heterogeneous tumors are more likely to be resistant to therapy and have reduced survival.
Kathleen Sprouffske, Grainne Kerr, Cheng Li, Anirudh Prahallad, Ramona Rebmann, Verena Waehle, Ulrike Naumann, Hans Bitter, Michael R Jensen, Francesco Hofmann, Saskia M Brachmann, Stéphane Ferretti, Audrey Kauffmann   +12 more
doaj   +1 more source

Clonal evolution of acute leukemia genomes [PDF]

Oncogene, 2012
In large part, cancer results from the accumulation of multiple mutations in a single cell lineage that are sequentially acquired and subject to an evolutionary process where selection drives the expansion of more fit subclones. Owing to the technical challenge of distinguishing and isolating distinct cancer subclones, many aspects of this clonal ...
M, Jan, R, Majeti
openaire   +2 more sources

Shuffling of mobile genetic elements (MGEs) in successful healthcare-associated MRSA (HA-MRSA). [PDF]

, 2012
Methicillin-resistant Staphylococcus aureus (MRSA) CC22 SCCmecIV is a successful hospital-associated (HA-) MRSA, widespread throughout the world, and now the dominant clone in UK hospitals.
Budd, EL, Knight, GM, Lindsay, JA, McCarthy, AJ   +3 more
core   +1 more source

Clonal Evolution Dynamics in Primary and Metastatic Lesions of Pancreatic Neuroendocrine Neoplasms

Frontiers in Medicine, 2021
Background: Data on inter-tumoral heterogeneity and clonal evolution of pancreatic neuroendocrine neoplasms (panNENs) with liver metastasis are limited.
Zhou Tong, Lin Wang, Weiwei Shi, Yanwu Zeng, Hangyu Zhang, Lulu Liu, Yi Zheng, Chunlei Chen, Weiliang Xia, Weijia Fang, Weijia Fang, Peng Zhao   +11 more
doaj   +1 more source

Clonal evolution of glioblastoma under therapy [PDF]

Nature Genetics, 2016
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. To better understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data from 114 patients. The analysis shows a highly branched evolutionary pattern in which 63% of patients experience expression-based subtype changes.
Jiguang Wang, Emanuela Cazzato, Erik Ladewig, Veronique Frattini, Daniel I S Rosenbloom, Sakellarios Zairis, Francesco Abate, Zhaoqi Liu, Oliver Elliott, Yong-Jae Shin, Jin-Ku Lee, In-Hee Lee, Woong-Yang Park, Marica Eoli, Andrew J Blumberg, Anna Lasorella, Do-Hyun Nam, Gaetano Finocchiaro, Antonio Iavarone, Raul Rabadan   +19 more
openaire   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Application of biomarkers in cancer risk management: evaluation from stochastic clonal evolutionary and dynamic system optimization points of view. [PDF]

PLoS Computational Biology, 2011
Aside from primary prevention, early detection remains the most effective way to decrease mortality associated with the majority of solid cancers. Previous cancer screening models are largely based on classification of at-risk populations into three ...
Xiaohong Li, Patricia L Blount, Thomas L Vaughan, Brian J Reid   +3 more
doaj   +1 more source

Clonal evolution of lymphoblastoid cell lines [PDF]

Laboratory Investigation, 2006
Lymphoblastoid cell lines represent Epstein-Barr virus (EBV)-immortalized B lymphocytes, which are typically prepared by in vitro culture of normal blood cells. In this study, we evaluated the kinetics of clonal evolution in lymphoblastoid cell lines (LCLs) established from five different donors.
Julie L, Ryan, William K, Kaufmann, Nancy, Raab-Traub, Stephen E, Oglesbee, Lisa A, Carey, Margaret L, Gulley   +5 more
openaire   +2 more sources

A Model of Genome Size Evolution for Prokaryotes in Stable and Fluctuating Environments [PDF]

, 2015
Temporal variability in ecosystems significantly impacts species diversity and ecosystem productivity and therefore the evolution of organisms. Different levels of environmental perturbations such as seasonal fluctuations, natural disasters, and global ...
Adami, Alon, Cock Van Oosterhout, Gause, Grimm, Koonin, Lynch, Piotr Bentkowski, Thomas Mock, Wagner   +9 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source