Results 111 to 120 of about 3,220,233 (234)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

An in vitro transcription-based protocol for mapping HIV integration sites using lentiviral integration site sequencing

STAR Protocols
Summary: Identification of integration sites of human immunodeficiency virus (HIV) is crucial for developing antiretroviral strategies. Here, we present an in vitro transcription-based version of lentiviral integration site sequencing (LIS-seq), enabling
Kamil Więcek, Janusz Wiśniewski, Heng-Chang Chen   +2 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effect of clonal integration on drought and waterlogging response in urochloa humidicola

Clonal integration allows for the sharing of resources such as water, nutrients, and photosynthates among individual subunits of clonal plants, promoting adaptation to diverse environmental and ecological conditions.
Mayorga, Mildred, Cardoso Arango, Juan Andres   +1 more
core  

Higher clonal integration in the facultative epiphytic fern Selliguea griffithiana growing in the forest canopy compared with the forest understorey

, 2015
Background and Aims The advantage of clonal integration (resource sharing between connected ramets of clonal plants) varies and a higher degree of integration is expected in more stressful and/or more heterogeneous habitats.
Wu, C. S., Li, S., Song, L., Qi, J. H., Lu, S. G., Liu, W. Y., Chen, X., Li, Y. P., Lu H. Z., Gong, H. D., Xu, X. L., Zheng, Y. L., Chen, K., Yu, F. H.   +13 more
core  

Clonal integration in Ranunculus reptans : by-product or adaptation?

, 2000
We studied fitness consequences of clonal integration in 27 genotypes of the stoloniferous herb Ranunculus reptans in a spatially heterogeneous light environment.
van Kleunen, Mark, Fischer, Markus, Schmid, Bernhard   +2 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Effects of clonal integration of Phragmites australis on the composition and biomass of soil microbial communities in a wetland contaminated by crude oil

, 2017
Connected asexual individuals (ramets) of clonal plants can transport and share resources such as water, nutrients,and photosynthates. Such clonal integration can enhance the capacity of ramets to tolerate environmental stresses, and thus may further ...
安菁, 韩广轩, 袁庆叶, 高俊琴, 于飞海   +4 more
core   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source