Results 71 to 80 of about 84,467 (284)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A comparison of the responses of mature and young clonal tea to drought. [PDF]

, 2001
To assist commercial producers with optimising the use of irrigation water, the responses to drought of mature and young tea crops (22 and 5 years after field planting respectively) were compared using data from two adjacent long-term irrigation ...
Burgess, Paul J., Carr, M. K. V., Nixon, D. J., Sanga, B. N. K.   +3 more
core   +1 more source

Genomic prediction and quantitative trait locus discovery in a cassava training population constructed from multiple breeding stages [PDF]

, 2020
Open Access Article; Published online: 11 Dec 2019Assembly of a training population (TP) is an important component of effective genomic selection‐based breeding programs.
Egesi, C., Jannink, Jean-Luc, Kawuki, R., Kulembeka, H., Lozano, R., Mrema, E., Mtunda, K., Ozimati, A., Rabbi, Ismail Y., Salum, K., Somo, M., Wolfe, M.D.   +11 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Clone Configuration and Spatial Genetic Structure of Two Halophila ovalis Populations With Contrasting Internode Lengths

Frontiers in Ecology and Evolution, 2019
Fine-scale spatial genetic structure (SGS) is predominantly determined by gene flow. While sexually reproducing plants can disperse their genes through pollen and seed grains, clonal plants can additionally disperse genes through clonal growth.
Na-Na Xu, Na-Na Xu, Kai Jiang, Kai Jiang, Shekhar R. Biswas, Xin Tong, Rong Wang, Xiao-Yong Chen, Xiao-Yong Chen   +8 more
doaj   +1 more source

Plant clonal morphologies and spatial patterns as self-organized responses to resource-limited environments

, 2014
We propose here to interpret and model peculiar plant morphologies (cushions, tussocks) observed in the Andean altiplano as localized structures. Such structures resulting in a patchy, aperiodic aspect of the vegetation cover are hypothesized to self ...
Anthelme, F., Clerc, M., Couteron, P., Escaff, D., Fernandez-Oto, C., Tlidi, M.   +5 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Predictable and stable epimutations induced during clonal plant propagation with embryonic transcription factor.

PLoS Genetics, 2022
Clonal propagation is frequently used in commercial plant breeding and biotechnology programs because it minimizes genetic variation, yet it is not uncommon to observe clonal plants with stable phenotypic changes, a phenomenon known as somaclonal ...
Anjar Tri Wibowo, Javier Antunez-Sanchez, Alexander Dawson, Jonathan Price, Cathal Meehan, Travis Wrightsman, Maximillian Collenberg, Ilja Bezrukov, Claude Becker, Moussa Benhamed, Detlef Weigel, Jose Gutierrez-Marcos   +11 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source