Results 161 to 170 of about 248,407 (299)

Crop year, harvest date and clone effects on fruit characteristics, chemical composition and olive oil stability from an Empeltre clonal selection grown in Aragon. [PDF]

J Sci Food Agric, 2022
Rey-Giménez R, Sánchez-Gimeno AC.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis. [PDF]

Nat Genet
McLoughlin MA, Cheloor Kovilakam S, Dunn WG, Gu M, Tobin J, Pershad Y, Williams N, Leongamornlert D, Dawson K, Bond L, Marando L, Wen S, Wilson R, Valenzano G, Symeonidou V, Rak J, Damaskou A, Gozdecka M, Liu X, Barcena C, Nomdedeu J, Costeas P, Dimitriou ID, Fiorillo E, Orrù V, de Almeida JG, McKerrell T, Cullen M, Mohorianu I, Foukaneli T, Warren AJ, Wong C, Follows G, Godfrey AL, Gudgin E, Cucca F, McKinney E, Baxter EJ, Gerstung M, Mitchell J, Wiseman D, Bick AG, Fabre M, Quiros PM, Nangalia J, Kar S, Vassiliou GS.   +46 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Clonal selection of pre-existing neuroendocrine component in prostate cancer during androgen receptor signaling inhibitor therapy: A case report. [PDF]

Urol Case Rep
Kubota H, Kijima T, Matsuda H, Uematsu T, Takei K, Yashi M, Ishida K, Kamai T.   +7 more
europepmc   +1 more source

Broad spectrum of regorafenib activity on mutant KIT and absence of clonal selection in gastrointestinal stromal tumor (GIST): correlative analysis from the GRID trial. [PDF]

Gastric Cancer, 2022
Jeffers M, Kappeler C, Kuss I, Beckmann G, Mehnert DH, Fredebohm J, Teufel M.   +6 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Exploratory analysis of lamivudine legacy and clonal selection of HBs truncation mutants in HBV-related hepatocellular carcinoma. [PDF]

Infect Agent Cancer
Chu YD, Ho PH, Hsu CW, Chiou CY, Lai MW, Yeh CT.   +5 more
europepmc   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms. [PDF]

Nat Commun
Maslah N, Kaci N, Roux B, Alexe G, Marie R, Pasquer H, Verger E, De Oliveira RD, Culeux C, Mlayah B, Gauthier N, Gonzales F, Zhao LP, Ganesan S, Gou P, Ling F, Soret-Dulphy J, Parquet N, Vainchenker W, Raffoux E, Padua RA, Giraudier S, Marty C, Plo I, Lobry C, Stegmaier K, Puissant A, Kiladjian JJ, Cassinat B, Benajiba L.   +29 more
europepmc   +1 more source