Results 61 to 70 of about 88,997 (296)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genetic variation and clonal diversity in introduced populations of Mimulus guttatus assessed by genotyping at 62 single nucleotide polymorphism loci [PDF]

, 2017
Background: Single nucleotide polymorphisms (SNPs) are increasingly being used to study non-native populations. SNPs are relatively information poor on a per locus basis, but allow genotyping more loci than others markers (e.g., microsatellites) and have
Joshua R. Puzey, Vallejo-Marín, Mario, Puzey, Joshua R, Pantoja, Pauline O., Puzey, Joshua R., Porcar, Violetta, Violeta I. Simón-Porcar, Vallejo‐Marín, Mario,, Pantoja, Pauline O, Pauline O. Pantoja, Mario Vallejo-Marín, Simon-Porcar, Violeta I.   +11 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Clonal Variation of Eucalypts in Susceptibility to Bacterial Wilt Detected by Using Different Inoculation Methods

, 2014
Summary Four inoculation methods were investigated for assessing the clonal variation of eucalypts in susceptibility to bacterial wilt (Ralstonia solanacearum).
Z. Luo, B. Fang, Run-Peng Wei
core   +1 more source

Genet dynamics and its variation among genets of a clonal plant Convallaria keiskei [PDF]

, 2023
In clonal plant populations, a number of genetically identical ramets form a genet. While coexisting ramets potentially perform independently, their behaviours not only depend on ages and sizes but are also constrained by genetic background.
Ohara, Masashi, Araki, Kiwako S., Kiwako S. Araki, Ichiro K. Shimatani, Shimatani, Ichiro K., Masashi Ohara   +5 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Impact of Hood Steaming on Tuber Vitality of Yellow Nutsedge (Cyperus esculentus)

Agronomy
Cyperus esculentus is a hard-to-control, destructive perennial weed propagating and spreading through rhizomes and tubers. Currently, a combination of mechanical, cultural, and chemical measures sustained over time is required for satisfactory control of
Jeroen Feys, Sander De Ryck, Clara Sciffer, Dirk Reheul, Joos Latré, Danny Callens, Benny De Cauwer   +6 more
doaj   +1 more source

Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations

Frontiers in Microbiology, 2019
Candida glabrata is an opportunistic fungal pathogen that currently ranks as the second most common cause of candidiasis. Although the mechanisms underlying virulence and drug resistance in C.
Laia Carreté, Laia Carreté, Ewa Ksiezopolska, Ewa Ksiezopolska, Emilia Gómez-Molero, Adela Angoulvant, Adela Angoulvant, Oliver Bader, Cécile Fairhead, Toni Gabaldón, Toni Gabaldón, Toni Gabaldón   +11 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source