Results 71 to 80 of about 2,152,291 (245)

Genome-wide characterisation of extant clonal diversity in Chilean Carménère

OENO One
Carménère is a widely cultivated and internationally recognised grapevine cultivar in Chile. Early studies based on SSR and AFLP markers detected limited polymorphism among clones in Chile, but these approaches interrogate only a small fraction of the ...
Jadran Garcia, Noé Cochetel, Jimena Balic, Samuel Barros, Rosa Figueroa-Balderas, Alvaro Castro, Dario Cantù   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Temperature-Dependent Clonal and Species-Level Growth Variation in Spirodela, Landoltia, Lemna, and Interspecific Lemna Hybrids

Plants
Duckweeds are minute, fast-growing monocot aquatic plants that propagate clonally and combine high biomass productivity with a valuable biochemical composition (high-quality proteins, a favorable polyunsaturated fatty acid profile, and starch-rich ...
Iride Mascheretti, Alessandra Mallardi, Claudia Liberatore, Tommaso Martinelli, Massimiliano Lauria   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Clonal Expansion from Standing Genetic Variation Underpins the Evolution of Curtobacterium flaccumfaciens pv. flaccumfaciens in Australia

Pathogens can evolve rapidly, leading to the emergence of novel strains that can overcome commercially deployed host plant resistance. Understanding the genetic and phenotypic diversity and population dynamics of plant pathogens is crucial to inform ...
Kelly, Lisa A., Sparks, Adam H., Vaghefi, Niloofar, Adorada, Dante L., Knight, Noel L., Colombi, Elena, Young, Anthony   +6 more
core   +1 more source

Karyological Variation of Clonal Malignant Cell Lines [PDF]

, 1991
Chromosomal analysis and DNA flow cytometry were performed on HeLa, malignant fibrous histiocytoma (MFH) and their clonal sublines. Two HeLa clones attained confluency in a 60-mm dish on the 45th day after cloning.
Sasaki, Kazuhiko, Tanaka, Rikuo, Honjou, Kazumitsu, Homma, Yutaka, Murakami, Tomoyuki, Nakada, Taishi, Nakanishi, Takashi   +6 more
core  

Origin, clonal diversity, and evolution of the parthenogenetic lizard Darevskia unisexualis

BMC Genomics, 2020
Background The hybridization of female D. raddei and male D. valentini gave rise to the parthenogenetic Caucasian rock lizard Darevskia unisexualis. A previously identified genetic polymorphism in the species consisted of one common and two allozyme ...
Andrey A. Vergun, Anastasiya E. Girnyk, Vitaly I. Korchagin, Seraphima K. Semyenova, Marine S. Arakelyan, Felix D. Danielyan, Robert W. Murphy, Alexey P. Ryskov   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Clonal Variation of Eucalypts in Susceptibility to Bacterial Wilt Detected by Using Different Inoculation Methods

, 2014
Summary Four inoculation methods were investigated for assessing the clonal variation of eucalypts in susceptibility to bacterial wilt (Ralstonia solanacearum).
Z. Luo, B. Fang, Run-Peng Wei
core   +1 more source

Flower Position and Clonal Integration Drive Intra-Individual Floral Trait Variation in Water-Hyacinth (Eichhornia crassipes, Pontederiaceae)

Biology
Intra-individual variation in floral traits is linked to plant fitness, playing a central role in sexual selection. This variation can arise from architectural constraints, such as flower position on the inflorescence axis, and from environmental factors.
Guilherme Ramos Demetrio, Luziene Seixas, Flávia de Freitas Coelho   +2 more
doaj   +1 more source