The use of high-throughput DNA sequencing in the investigation of antigenic variation: application to Neisseria species. [PDF]
PLoS ONE, 2014 Antigenic variation occurs in a broad range of species. This process resembles gene conversion in that variant DNA is unidirectionally transferred from partial gene copies (or silent loci) into an expression locus. Previous studies of antigenic variation
John K Davies +8 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Growth, Biomass Production and Yield Variation in Eucalyptus Clones [PDF]
Journal of Stress Physiology & Biochemistry, 2020 Eucalyptus are among the most widely cultivated forest trees in the world under a range of different climates for products that include pulp, paper fuel wood and solid wood products such as poles, furniture and construction timber.
S. Saravanan
doaj
Deep sequencing is an appropriate tool for the selection of unique Hepatitis C virus (HCV) variants after single genomic amplification. [PDF]
PLoS ONE, 2017 Hepatitis C virus (HCV) evolves rapidly in a single host and circulates as a quasispecies wich is a complex mixture of genetically distinct virus's but closely related namely variants.
Thibault Guinoiseau +7 more
doaj +1 more source
Location-Dependent DNA Methylation Signatures in a Clonal Invasive Crayfish
Frontiers in Cell and Developmental Biology, 2021 DNA methylation is an important epigenetic modification that has been repeatedly implied in organismal adaptation. However, many previous studies that have linked DNA methylation patterns to environmental parameters have been limited by confounding ...
Sina Tönges +7 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
, 2010 The classical myeloproliferative disorders (MPD), comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling ...
core +1 more source
Clonal Variation In Proliferation Rate of Cultures of Gpk Cells
Cell Proliferation, 1981 ABSTRACTPedigrees of twenty‐six clones of a line of keratocytes derived from guinea‐pig ear epidermis (GPK cells) were analysed from time‐lapse film. the mean interdivision time (IDT) for the culture was 1143 φ 215 (SD) min. the mean generation rates (mean reciprocal interdivision times) of clones varied over a range of 3.93–10.2 × 10‐4/min and the ...
P A, Riley, M, Hola
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Clonal variation of the basic resistance factors (POD, SOD, CAT, MDA, PRO) in Michelia chapensis
Biologia PlantarumMichelia chapensis Dandy, a rare and endangered evergreen woody species of the genus Michelia (Magnoliaceae), is endemic to China, with only scattered natural communities (Zhou et al., 2023).
Houyin DENG +7 more
doaj +1 more source