Results 51 to 60 of about 2,152,291 (245)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Phenotypic variation among Phytophthora ramorum isolates from California and Oregon [PDF]

, 2006
To manage and control Phytophthora ramorum successfully, it is important to know the amount of phenotypic variation within a given pathogen population.
Miles, L., Hüberli, D., Harnik, T.Y., Meshriy, M., Garbelotto, M.   +4 more
core  

Genealogical typing of Neisseria meningitidis [PDF]

, 2009
Despite the increasing popularity of multilocus sequence typing (MLST), the most appropriate method for characterizing bacterial variation and facilitating epidemiological investigations remains a matter of debate.
Falush, Daniel, Didelot, X, Falush, D, Didelot, Xavier, Maiden, Martin C. J., Maiden, MC, Urwin, R, Urwin, Rachel   +7 more
core   +1 more source

Evaluating Clonal Diversity in ‘Merzifon Karası’ (Vitis vinifera) for Yield, Cluster Characteristics, and Millerandage Index

Horticulturae
This study examined clonal variation in Vitis vinifera L. cv. ‘Merzifon Karası’, a Turkish wine grape. Thirty-two clones were evaluated for key growth and enological characteristics, including cluster structure, berry attributes, yield components ...
Kevser Bayram, Bülent Köse, Harlene Hatterman-Valenti   +2 more
doaj   +1 more source

Clonal amplification of Fasciola hepatica in Galba truncatula: within and between isolate variation of triclabendazole-susceptible and -resistant clones

Parasites & Vectors, 2018
Background Fasciola hepatica is of worldwide significance, impacting on the health, welfare and productivity of livestock and regarded by WHO as a re-emerging zoonosis.
Jane E. Hodgkinson, Krystyna Cwiklinski, Nicola Beesley, Catherine Hartley, Katherine Allen, Diana J. L. Williams   +5 more
doaj   +1 more source

TERT and TET2 Genetic Variants Affect Leukocyte Telomere Length and Clinical Outcome in Coronary Artery Disease Patients—A Possible Link to Clonal Hematopoiesis

Biomedicines, 2022
Inherited and acquired mutations in hematopoietic stem cells can cause clonal expansion with increased risk of cardiovascular disease (CVD), a condition known for the clonal hematopoiesis of indeterminate potential (CHIP).
Trine B. Opstad, Svein Solheim, Alf-Åge R. Pettersen, Are A. Kalstad, Harald Arnesen, Ingebjørg Seljeflot   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Growth, Biomass Production and Yield Variation in Eucalyptus Clones [PDF]

Journal of Stress Physiology & Biochemistry, 2020
Eucalyptus are among the most widely cultivated forest trees in the world under a range of different climates for products that include pulp, paper fuel wood and solid wood products such as poles, furniture and construction timber.
S. Saravanan
doaj  

The use of high-throughput DNA sequencing in the investigation of antigenic variation: application to Neisseria species. [PDF]

PLoS ONE, 2014
Antigenic variation occurs in a broad range of species. This process resembles gene conversion in that variant DNA is unidirectionally transferred from partial gene copies (or silent loci) into an expression locus. Previous studies of antigenic variation
John K Davies, Paul F Harrison, Ya-Hsun Lin, Stephanie Bartley, Chen Ai Khoo, Torsten Seemann, Catherine S Ryan, Charlene M Kahler, Stuart A Hill   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source