Results 101 to 110 of about 39,199 (304)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Mega Clonality in an Aquatic Plant—A Potential Survival Strategy in a Changing Environment
Frontiers in Plant Science, 2018 Many ecosystems are experiencing rapid transformations due to global environmental change. Understanding how ecological shifts affect species persistence is critical to modern management strategies.
Eric Bricker +4 more
doaj +1 more source
The ecological and evolutionary consequences of clonality for plant mating
, 2010 Many flowering plants exhibit dual reproductive modes, producing both sexual and asexual offspring. The commonest form of asexual reproduction is clonal growth, in which vegetative modules (ramets) are produced by the parental genotype (genet). In plants,
Dorken, Marcel E +8 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Антибиотики и Химиотерапия, 2020 The problem of hospital-acquired infections due to coagulase-negative staphylococci (CoNS) in neonatal intensive care units is crucial over the last 20 years in the world.
L. A. Lubasovskaya +4 more
doaj
On the clonality of tumours [PDF]
British Journal of Cancer, 1985 M F, Woodruff, J D, Ansell
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Clonal haematopoiesis and clonal selection in wine [PDF]
Bone Marrow Transplantation, 2020 openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Journal for ImmunoTherapy of CancerBackground T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic ...
Mats Nilsson +17 more
doaj +1 more source