Results 111 to 120 of about 29,987 (218)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series. [PDF]

Front Oncol
Zhang JS, Ng JCK, Hermida de Viveiros P, Al-Marayaty R, Al Akoum N, Shinglot H, Jing W, Vizcaino V, Alexiev BA, Cranmer LD, Loggers ET, Abrams H, Wagner MJ, Pillarisetty VG, Kim EY, Pierce RH, Berglund P, Jones RL, Lu H, Ter Meulen J, Pollack SM, Seo YD.   +21 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Access to diagnosis using liquid biopsy (ADLiB): Identifying lymphoma in a tuberculosis-endemic setting. [PDF]

Hemasphere
Antel K, Xiong N, Merrill M, Chen T, McGrath L, Droessler C, van der Schyff M, Wu MX, Cheddie D, Slome C, McBride L, Day J, Mohamed Z, Fakie N, Mbatani N, Shultz C, Meintjes G, Tyekucheva S, Cohen EF, Tolstorukov MY, Verburgh E, Murakami MA.   +21 more
europepmc   +1 more source

Attack of the Clones: Microglia in Health and Disease

Frontiers in Cellular Neuroscience, 2022
Amritha Vinayak Manjally, Amritha Vinayak Manjally, Amritha Vinayak Manjally, Tuan Leng Tay, Tuan Leng Tay, Tuan Leng Tay, Tuan Leng Tay, Tuan Leng Tay   +7 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

TCR sequencing in cancer immunology and immunotherapy: what, when, where, why, and how. [PDF]

J Immunother Cancer
Nose Y, Figueiredo I, Tuballes K, Del Valle DM, Gonsalves TR, Guo R, Ioannou G, Cabal R, Gonzalez-Kozlova E, Gnjatic S.   +9 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

The Clonal Conundrum: Clonal CD4⁺ Cutaneous Lymphoid Infiltrate in a Toddler Along a Reactive Primary Cutaneous CD4⁺ Small/Medium T-cell Lymphoproliferative Disorder (PCSM-TCLPD) Spectrum. [PDF]

Cureus
Naidnur S, Maedo K, Neave SA, DeSantis E, Lin R.   +4 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source