Results 51 to 60 of about 55,715 (309)

Clonal plasticity [PDF]

Proceedings of the 11th International Symposium on Software Engineering for Adaptive and Self-Managing Systems, 2016
This paper introduces a new plant-inspired mechanism for decentralized adaptation, called clonal plasticity , which does not make use of the MAPE loop. The mechanism acts on ev- ery individual in a population and does not require central- ized control. The paper presents a case-study demonstrating its utility and feasibility in adaptation.
Vivek Nallur, Nicolás Cardozo, Siobhán Clarke   +2 more
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Clonal Composition of Human Adrenocortical Neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Abdelhamid, S., Allolio, B., Beuschlein, Felix, Chrousos, G. P., Jaursch-Hancke, C., Karl, M., Reincke, Martin, Travis, W.   +7 more
core  

Transcript-indexed ATAC-seq for precision immune profiling. [PDF]

, 2018
T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding
Buenrostro, Jason D, Chang, Howard Y, Corces, M Ryan, Davis, Mark M, Gennert, David G, Granja, Jeffrey M, Greenleaf, William J, Khavari, Paul A, Khodadoust, Michael S, Kim, Youn H, Lareau, Caleb A, Li, Rui, Mumbach, Maxwell R, Parker, Kevin R, Qi, Yanyan, Rubin, Adam J, Saligrama, Naresha, Satpathy, Ansuman T, Schep, Alicia N, Serratelli, William S, Wei, Yuning, Wu, Beijing   +21 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Microenvironment-Driven Dynamic Heterogeneity and Phenotypic Plasticity as a Mechanism of Melanoma Therapy Resistance

Frontiers in Oncology, 2018
Drug resistance constitutes a major challenge in designing melanoma therapies. Microenvironment-driven tumor heterogeneity and plasticity play a key role in this phenomenon. Melanoma is highly heterogeneous with diverse genomic alterations and expression
Farzana Ahmed, Nikolas K. Haass, Nikolas K. Haass   +2 more
doaj   +1 more source

Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas. [PDF]

, 2017
Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly characterized variant of cutaneous lymphoma still considered a provisional entity in the latest 2016 World Health Organization Classification of Cutaneous ...
Duvic, Madeleine, Girardi, Michael, Guitart, Joan, Ivan, Doina S, Junkins-Hopkins, Jacqueline, Kim, Ellen, Kim, Jinah, Kim, Youn H, Martinez-Escala, M Estela, Olsen, Elise A, Pincus, Laura B, Pulitzer, Melissa P, Rook, Alain H, Sable, Kimberly A, Samimi, Sara S, Selim, M Angelica, Subtil, Antonio, Tetzlaff, Michael T, Virmani, Pooja, Wood, Gary S   +19 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Pcr definition of b-cell clonality: which electrophoretic method is better

Терапевтический архив, 2008
Aim. To compare diagnostic efficacy of B-cell clonality determination in application of different electrophoretic methods. Material and methods. B-cell clonality was determined with different techniques in 89 patients having B-cell lymphoma (n = 48), B ...
Iu V Sidorova, E A Nikitin, N V Ryzhikova, A B Sudarikov   +3 more
doaj  

The clinical characteristics of autoimmune haemolytic anaemia/Evans syndrome patients with clonal immunoglobulin/T cell receptor gene rearrangement

Autoimmunity, 2020
Objective To investigate the clinical features of AIHA/ES patients with clonal Ig/TCR gene rearrangement. Methods Ig/TCR gene rearrangements were measured by BIOMED-2 PCR. 44 primary AIHA/ES patients were enrolled in the study.
Hongli Zhu, Manjun Zhao, Zeng Cao, Jin Yang, Yi Li, Limin Xing   +5 more
doaj   +1 more source