Results 221 to 230 of about 790,447 (335)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer. [PDF]

Nat Commun
Mikutenaite M, Karadoulama E, Favero F, Locallo A, Gonzalez FGR, Kiriy D, Keshavarzian T, Furlano K, Graefen M, Bristow RG, Gerhäuser C, Plass C, Sauter G, Simon R, Lupien M, Minner S, Schlomm T, Weischenfeldt J.   +17 more
europepmc   +1 more source

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells.

, 1988
David Harding, Sylvie Fournel‐Gigleux, Michael R. Jackson, Brian Burchell   +3 more
openalex   +2 more sources

Acute extracellular acidification reduces intracellular pH, 42°C-induction of heat shock proteins and clonal survival of human melanoma cells grown at pH 6.7 [PDF]

, 2003
Ronald A. Coss, Christopher Storck, Phyllis Wachsberger, Judith Reilly, Dennis B. Leeper, David Berd, M Wahl   +6 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The Phospholipid Bis(monoacylglycero)Phosphate Confers Antitumour Immunogenicity to Exosomes Secreted by Dendrogenin A, Which Activates Its Biosynthesis in Tumour Cells. [PDF]

J Extracell Vesicles
Buñay J, Record M, de Medina P, Ayadi S, Pucheu L, Colacios C, Ségui B, Höring M, Liebisch G, Martin H, Poirot M, Silvente-Poirot S.   +11 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Interleukin-2 is a potent latency reversal agent in people with treated HIV-1. [PDF]

Sci Adv
Freeman ML, Clagett BM, Leskov K, Moisi D, Yendewa GA, Sieg SF, Laird GM, Karn J, Jacobson JM, Rodriguez B, Lederman MM.   +10 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Anti-human TLR7 antibody for therapeutic intervention in systemic lupus erythematosus. [PDF]

Int Immunol
Fukui R, Murakami Y, Kanno A, Motoi Y, Manno A, Honda T, Yamada S, Ishiguro J, Kagari T, Nakamura K, Kadokura M, Isobe T, Tomimori Y, Tanaka J, Senaldi G, Shimizu T, Miyake K.   +16 more
europepmc   +1 more source