Results 241 to 250 of about 750,149 (308)

Sequential, chromosome-specific glutamine synthetase double knockout with Cas-CLOVER establishes enhanced CHO platforms for cell line development. [PDF]

Biotechnol Prog
Limia CG, Steffey V, Cheng HC, Machado D, Hart T, McHargue MC, Brizzee C, Crawford J.   +7 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets. [PDF]

Life Sci Alliance
Bouma RG, de Leeuw WJ, Wang AZ, Malik M, Stolwijk JG, Konijn VA, Mensink A, Proost N, Nijen Twilhaar MK, van Welsem T, Seyed Toutounchi N, Affandi AJ, van Dinter JT, van Leeuwen F, den Haan JM.   +14 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Protocol for analyzing immune cell infiltration in 3D pancreatic heterotypic spheroids composed of tumor cells and cancer-associated fibroblasts. [PDF]

STAR Protoc
Thomas B, Nadia VV, Clara F, Nelly P, Nathalie B, Celine G, Christel L, Laurent G.   +7 more
europepmc   +1 more source

Hypoxia-induced metabolic and apoptotic reprogramming enhances immunomodulation in Wharton's jelly mesenchymal stem cells. [PDF]

iScience
Mendiratta M, Mendiratta M, Mohanty S, Prakash H, Malhotra L, Rai S, Sarangathem V, Bandyopadhyay S, Hariprasad G, Gupta R, Bakhshi S, Dadhwal V, Pushpam D, Aggarwal M, Gupta AK, Malik PS, Pramanik R, Mahapatra M, Seth T, Dhawan R, Nayak B, Singh TD, Kumar S, Mir RA, Sharawat SK, Sahoo RK.   +25 more
europepmc   +1 more source

Sexual dimorphism of early GPR183-dependent B cell responses in systemic lupus erythematosus. [PDF]

iScience
Matei DE, de Gruijter NM, Jenkins P, Radziszewska A, Peckham H, Jebson B, Karu K, Ciurtin C, Rosser EC.   +8 more
europepmc   +1 more source

TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size. [PDF]

Nat Immunol
Ghneim K, Ten-Caten F, Santana AC, Latif MB, Diaz-Dinamarca DA, García-Salum T, Del Rio Estrada PM, Sohal P, Strongin Z, Harper J, Jean S, Wallace C, Balderas R, Lifson JD, Raghunathan G, Rimmer E, Pastuskovas CV, Wu G, Micci L, Martins Sieben LF, Lopes Gerum PC, Dos Santos J, Netea MG, van der Ven A, Silvestri G, Hazuda DJ, Gorman DM, Howell BJ, Sharma AA, Paiardini M, Soudeyns H, Pereira Ribeiro S, Sekaly RP.   +32 more
europepmc   +1 more source