Results 121 to 130 of about 1,799,485 (379)
Genes & Development, 1989 An activating transcription factor (ATF)-binding site (consensus sequence 5'-GTGACGTACAG-3') is a promoter element present in a wide variety of viral and cellular genes. The two best-characterized classes of genes that contain ATF sites are E1A-inducible
Tsonwin Hai, F. Liu, W. Coukos, M. Green
semanticscholar +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Вавиловский журнал генетики и селекции, 2017 The formation of plus trees assortment for seed orchards is one of the most difficult problems of contemporary forest breeding. This problem is related to the risk of inbreeding depression of the seed progeny of plus trees, which do not have any defense ...
N. N. Besschetnova, V. P. Besschetnov
doaj +1 more source
Clone Removal in Java Programs as a Process of Stepwise Unification [PDF]
, 2013 Cloned code is one of the most important obstacles against consistent software maintenance and evolution. Although today's clone detection tools find a variety of clones, they do not offer any advice how to remove such clones.
Bremm, Andri, Speicher, Daniel
core
This Element explores the rationality and morality of the kind of human reproductive cloning that does not involve genetic enhancements or other biological alterations in the individuals produced. The analysis is needed because, sooner or later, the technique will be safe enough to be tested; yet its pros and cons have not been sufficiently ...
Häyry Matti, Takala Tuija-Maija
openaire +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Journal of Infection in Developing Countries, 2011 Introduction: Non-typhoidal Salmonella (NTS) contamination in poultry and poultry products is a major cause of food-borne disease in humans. This study presents the molecular epidemiology of NTS isolated from poultry in Senegal.
Michel M Dione +2 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source