Results 301 to 310 of about 1,799,485 (379)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genomic and epidemiological insights into the emergence and dominance of MRSA clones in Riyadh's healthcare facilities. [PDF]

Sci Rep
Alkuraythi DM, Alkhulaifi MM, Altwiley DA, Alarwi M, Mujallad MI, Alshomrani MK, Gojobori T, Alajel SM.   +7 more
europepmc   +1 more source

Monosaccharide inhibition of cytotoxic T-cell function: demonstration of clone-specific effects.

, 1988
Helen C. O’Neill, Christopher R. Parish   +1 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Maspardin/SPG21 controls lysosome motility and TFEB phosphorylation through RAB7 positioning. [PDF]

J Cell Biol
Jacqmin T, Gilis F, Albert M, Gaussin JF, Jadot M, Boonen M.   +5 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis. [PDF]

Nat Genet
Yoshizato T, Nilsson C, Grasso F, Högstrand K, Mazzi S, Winroth A, Lehander M, Barbosa I, Waldin G, Mortera-Blanco T, Jansson M, Widfeldt MH, Aliouat A, Brennan MS, Markljung E, Hillen A, Chari E, Hellström-Lindberg E, Kretzschmar WW, Woll PS, Jacobsen SEW.   +20 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source