Results 201 to 210 of about 805,120 (315)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (<i>Pteropus alecto</i>). [PDF]

Front Immunol
Hen JJ, Isaacs A, Liang B, Schountz T, Chappell K, Young PR, Modhiran N, Watterson D.   +7 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Characterization of the <i>cpt1b</i> Gene in Response to a Tributyrin-Supplemented Diet: Cloning, Tissue-Specific Expression, and Intestinal Metabolic Function in Mandarin Fish (<i>Siniperca chuatsi</i>). [PDF]

Curr Issues Mol Biol
Xu EX, Guo Y, Xu YH, Bao TF, Wu CB, Gao XW, Gong CG.   +6 more
europepmc   +1 more source

Molecular cloning of mouse cathepsin D

Nucleic Acids Research, 1990
M J, Grusby, S C, Mitchell, L H, Glimcher   +2 more
openaire   +3 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

"Expression of a recombinant chimeric capsid-nucleocapsid protein from bovine leukemia virus genotype 1 for the diagnosis of enzootic bovine leukosis". [PDF]

Vet Res Commun
Sánchez Gasca JH, Cuevas Romero JS, Cerriteño Sánchez JL, Rodríguez-Murillo C, Acevedo-Jiménez GE, Ramírez Álvarez H.   +5 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Immunoinformatics approach to engineer a multi-epitope vaccine against SdrG in skin commensal Staphylococcus epidermidis. [PDF]

PLoS One
Akter S, Silva GVR, Oliveira JIN, Fulco UL, Xu X, Fu YV.   +5 more
europepmc   +1 more source