Results 191 to 200 of about 805,120 (315)

Cloning: Legal, Medical, Ethical and Social Issues: Hearing before the Subcommittee on Health and Environment of the Committee on Commerce, U.S. House of Representatives, February 12, 1998: The Written Testimony of Dianne N. Irving, M.A., Ph.D. [PDF]

, 1999
Irving, Dianne N.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cloning and Characterization of <i>IbDREB1d</i> and Its Role in Plant Growth Regulation in Sweet Potato. [PDF]

Plants (Basel)
Li G, Xu Y, Lin Z, Zhang H, Xie S, Qiu Y, Xu G, Li H, Ji R, Luo W, Tang H, Qiu SX.   +11 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Multi-epitope vaccine design against Monkeypox virus: An immunoinformatics approach. [PDF]

PLoS One
Ahmad S, Aslam S, Khalid A.
europepmc   +1 more source

Expressed sequence tag survey of gene expression in the scab mite Psoroptes ovis--allergens, proteases and free-radical scavengers [PDF]

, 2003
Blaxter, M L, Kenyon, F, Knox, D P, Parkinson, J, Welsh, M, Whitton, C   +5 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identification, Cloning and Expression of Ferritin M-like Subunit from the Indian Oyster, <i>Magallana bilineata</i> (Röding, 1798). [PDF]

Genes (Basel)
Arshad E, Pradeep MA, Kumar G, Dhanutha NR, Nisha EA, Shahansha TSA, Vijayan KK.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Immunoinformatics-driven design of multi-epitope vaccine targeting antibiotic-resistant Salmonella typhimurium. [PDF]

PLoS One
Khan A, Ahmad A, Badshah F, Ali M, Khan MS, Naz W, Ibánez-Arancibia E, De Los Ríos-Escalante PR, Yassin MT.   +8 more
europepmc   +1 more source