Results 101 to 110 of about 1,949,061 (374)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Multipartite Asymmetric Quantum Cloning

, 2004
We investigate the optimal distribution of quantum information over multipartite systems in asymmetric settings. We introduce cloning transformations that take $N$ identical replicas of a pure state in any dimension as input, and yield a collection of ...
A. Acín, J. Fiurášek, J. Preskill, M. Keyl, N. Gisin, N. J. Cerf, N. J. Cerf, N. J. Cerf, R. Filip, S. Iblisdir   +9 more
core   +2 more sources

p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease [PDF]

, 1995
M.‐B. Huang, Jan M. Orenstein, Malcolm A. Martin, Eric O. Freed   +3 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Phase covariant quantum cloning

, 1999
We consider an N -> M quantum cloning transformation acting on pure two-level states lying on the equator of the Bloch sphere. An upper bound for its fidelity is presented, by establishing a connection between optimal phase covariant cloning and phase ...
A.S. Holevo, C. A. Fuchs, C. H. Bennett, Chiara Macchiavello, D. Bruß, D. Bruß, Dagmar Bruß, G. Mauro D’Ariano, H.P. Yuen, K. Kraus, Mirko Cinchetti, N. Gisin, R. Derka, R. Werner, S. Massar, W.K. Wootters   +15 more
core   +1 more source

Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly [PDF]

, 2006
Sine Reker Hadrup, Jan Strindhall, Tania Køllgaard, Tina Seremet, Boo Johansson, Graham Pawelec, Per thor Straten, Anders Wikby   +7 more
openalex   +1 more source

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

, 2022
Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu, Atsunari Kawashima, Atsushi Tanaka, Yudai Sonoda, Yumi Tona, Kunitaka Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, Keiji Dohi, Takayuki Kanazawa, Azumi Ueyama, Mai Yoshikawa, Tetsuya Yoshida, Mitsunobu Matsumoto, Kanji Hojo, Satomi Shinonome, Hiroshi Yoshida, Michinari Hirata, Miya Haruna, Yamami Nakamura, Daisuke Motooka, Daisuke Okuzaki, Yasuko Sugiyama, Makoto Kinoshita, Tatsusada Okuno, Taigo Kato, Koji Hatano, Motohide Uemura, Ryoichi Imamura, Kazunori Yokoi, Atsushi Tanemura, Yasushi Shintani, Tadashi Kimura, Norio Nonomura, Hisashi Wada, Masaki Mori, Yuichiro� Doki, Naganari Ohkura, Shimon Sakaguchi   +41 more
openalex   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Quantum cloning attacks against PUF-based quantum authentication systems

, 2016
With the advent of Physical Unclonable Functions (PUFs), PUF-based quantum authentication systems (QAS) have been proposed for security purposes and recently proof-of-principle experiment has been demonstrated.
Gao, Ming, Li, Mo, Yao, Yao, Zhang, Jian
core   +1 more source

Pure Cloning

This Element explores the rationality and morality of the kind of human reproductive cloning that does not involve genetic enhancements or other biological alterations in the individuals produced. The analysis is needed because, sooner or later, the technique will be safe enough to be tested; yet its pros and cons have not been sufficiently ...
Häyry Matti, Takala Tuija-Maija
openaire   +2 more sources