Results 71 to 80 of about 8,628 (260)

Photodynamic therapy of cancer‐associated infections

Photochemistry and Photobiology, Volume 101, Issue 4, Page 833-845, July/August 2025.
Pathogens can be involved in tumor initiation, promotion and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections, and, therefore, has a unique potential to address ...
Giulia Kassab, Juan Chen, Gang Zheng
wiley   +1 more source

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the effects of climate change on the risk of transmission of foodborne pathogens

Food Risk Assess Europe, Volume 3, Issue 3, July 2025.
Abstract The Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) has carried out an updated review of the scientific evidence on the influence of climate change on the transmission of foodborne pathogens. This global phenomenon represents an emerging threat to food safety and public health, since alterations in weather ...
Antonio Valero Díaz, Rosa María Capita González, Baltasar Mayo Pérez, Azucena del Carmen Mora Gutiérrez, María Dolores Rodrigo Aliaga, Gloria Sánchez Moragas, Paula Arrabal Durán   +6 more
wiley   +1 more source

The Future of Pathogen Detection in Aquaculture: Miniature Labs, Field‐Compatible Assays, environmental DNA and RNA, CRISPR and Metatranscriptomics

Aquaculture, Fish and Fisheries, Volume 5, Issue 3, June 2025.
ABSTRACT Inland recirculating aquaculture is a thriving food industry providing sustainable and locally sourced high‐quality protein. However, its expansion is accompanied by emerging challenges regarding the spread of pathogens and diseases. Detection and management of pathogens in aquaculture remain underdeveloped compared to other animal farming ...
Jessica Rieder, Anastasiia Berezenko, Alexandra Meziti, Irene Adrian‐Kalchhauser   +3 more
wiley   +1 more source

Characterization of the E26H Mutant Schistosoma japonicum Glutathione S‐Transferase

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 5, Page 1054-1066, May 2025.
ABSTRACT Glutathione‐S‐transferase, such as that of Schistosoma japonicum (sjGST) belongs to the most widely utilized fusion tags in the recombinant protein technology. The E26H mutation of sjGST has already been found to remarkably improve its ability for binding divalent ions, enabling its purification with immobilized metal affinity chromatography ...
János András Mótyán, Ágota Nagyné Veres, József Tőzsér   +2 more
wiley   +1 more source

Bird's eye view of natural products for the development of new anti‐HIV agents: Understanding from a therapeutic viewpoint

Animal Models and Experimental Medicine, Volume 8, Issue 3, Page 441-457, March 2025.
Development of pharmaceutical drugs to cure HIV is crucial due to the current widespread epidemic. Nucleosides are the most effective anti‐HIV drugs, but their high toxicity and drug resistance limit their use. This review focuses on potential natural medicinal products for treating and managing HIV and AIDS.
Md. Al Amin, Mohamed H. Nafady, Mehrukh Zehravi, Sherouk Hussein Sweilam, Kusuma Praveen Kumar, M. Akiful Haque, Aziz Unnisa, Laliteshwar Pratap Singh, Mohammed Sayeed, Mohammed Ali Alshehri, Irfan Ahmad, Talha Bin Emran, Md. Zia Uddin   +12 more
wiley   +1 more source

An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM‐1.C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Using a combination of bioinformatics, sequence and structural analyses, we designed derivatives of the parasite‐derived helminth defense molecule to determine a relationship between the peptide structure and its immune regulatory function. Screening these derivatives in a series of assays related to the activation of inflammatory macrophages, we ...
Richard Lalor, Akane Tanaka, Jenna Shiels, Aakanksha Dixit, Sabine Hoadley, Eloïse Dufourd, Siobhan Hamon, Joyce To, Clifford C. Taggart, Sinead Weldon, Bronwyn O'Brien, Judith Greer, John P. Dalton, Sheila Donnelly   +13 more
wiley   +1 more source

EZH2‐Mediated PHF10 Suppression Amplifies HMGB1/NF‐κB Axis That Confers Chemotherapy Resistance in Cholangiocarcinoma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Chemoresistance represents a major threat to the treatment of human cancers, including cholangiocarcinoma (CHOL). Aberrant epigenetic events contribute most to the progression of CHOL and chemotherapy efficacy. PHF10, one subunit of SWI/SNF complex, expressed highly in tumours that correlated with tumorigenesis.
Qiushi Yin, Daning Lin, Weiqian Zeng, Shijing Gu, Chuangshi Zhu, Changfu Liang, Yan Yang   +6 more
wiley   +1 more source

Clonorchis sinensis antigens alter hepatic macrophage polarization in vitro and in vivo. [PDF]

PLoS Neglected Tropical Diseases, 2017
Clonorchis sinensis infection elicits hepatic inflammation, which can lead to cholangitis, periductal hepatic fibrosis, liver cirrhosis, and even cholangiocarcinoma. Hepatic macrophages are an intrinsic element of both innate and acquired immunity.
Eun-Min Kim, You Shine Kwak, Myung-Hee Yi, Ju Yeong Kim, Woon-Mok Sohn, Tai-Soon Yong   +5 more
doaj   +1 more source

Patent Landscape of Helminth Vaccines and Related Technologies [PDF]

, 2013
Executive Summary This report focuses on patent landscape analysis of technologies related to vaccines targeting parasitic worms, also known as helminths.
Burke, Rayna, Cavicchi, Jon R., Kowalski, Stanley P., Michaud-King, Jillian, Schroeder, John   +4 more
core   +1 more source

New insights from Opisthorchis felineus genome: update on genomics of the epidemiologically important liver flukes

BMC Genomics, 2019
Background The three epidemiologically important Opisthorchiidae liver flukes Opisthorchis felineus, O. viverrini, and Clonorchis sinensis, are believed to harbour similar potencies to provoke hepatobiliary diseases in their definitive hosts, although ...
Nikita I. Ershov, Viatcheslav A. Mordvinov, Egor B. Prokhortchouk, Mariya Y. Pakharukova, Konstantin V. Gunbin, Kirill Ustyantsev, Mikhail A. Genaev, Alexander G. Blinov, Alexander Mazur, Eugenia Boulygina, Svetlana Tsygankova, Ekaterina Khrameeva, Nikolay Chekanov, Guangyi Fan, An Xiao, He Zhang, Xun Xu, Huanming Yang, Victor Solovyev, Simon Ming-Yuen Lee, Xin Liu, Dmitry A. Afonnikov, Konstantin G. Skryabin   +22 more
doaj   +1 more source