Results 91 to 100 of about 178,738 (259)

Changes in Practice Patterns of Clopidogrel in Combination with Proton Pump Inhibitors after an FDA Safety Communication.

PLoS ONE, 2016
ObjectivesIn 2009, the FDA issued a warning that omeprazole--a proton pump inhibitor (PPI)--reduces the antithrombotic effect of clopidogrel by almost half when taken concomitantly.
Annie Guérin, Reema Mody, Valerie Carter, Charles Ayas, Haridarshan Patel, Karen Lasch, Eric Wu   +6 more
doaj   +1 more source

Drug-drug interactions in repeat prescriptions at village dispensaries (bereg) in Malta [PDF]

, 2013
Inappropriate treatments and drug-drug interactions (DDIs) are known to occur in settings where repeat prescriptions are issued. In view of this, a study was carried out to document any such problematic drug prescribing and propose changes that would
Bugeja, Anton
core  

Increased Expression of Cell-Cell Signaling Genes by Stimulated Mononuclear Leukocytes in Patients with Previous Atherothrombotic Stroke A Whole Genome Expression Profile Study [PDF]

, 2009
Background/Aims: Inflammation plays an important role in atherosclerosis and stroke. Acute infections are recognized as trigger factors for ischemic stroke. Methods: In this whole genome expression profile study of 15 patients and 15 control subjects, we
Grau, Armin J., Grond-Ginsbach, Caspar, Hergenhahn, Manfred, Hollstein, Monika, Honold, Cornelius, Horstmann, Solveig, Hummel, Manuela, Knyazev, Yuri, Mansmann, Ulrich, Pfleger, Karin, Wagner, Simone, Weninger, Annette, Wiest, Tina   +12 more
core   +1 more source

Impact of Proton Pump Inhibitor Use on Outcomes Following Carotid Artery Stenting for Asymptomatic Carotid Stenosis: A Population‐Based Cohort Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Carotid artery stenting (CAS) is an effective treatment for carotid stenosis. Proton‐pump inhibitors (PPIs) are commonly prescribed in the general population. However, the impact of PPI use on outcomes following CAS remains unknown. This study investigated the impact of PPI use on CAS using a retrospective, matched‐cohort analysis from the ...
Chia‐En Wong, Pang‐Shuo Perng, Pei‐Wen Chen, Yu Chang, Chih‐Hao Tien, Jung‐Shun Lee, Liang‐Chao Wang, Chih‐Yuan Huang   +7 more
wiley   +1 more source

Evaluation of clopidogrel responsiveness using the Platelet Function Analyzer-200 (PFA-200) in dogs

Frontiers in Veterinary Science
We aimed to evaluate the prevalence of clopidogrel resistance in hypercoagulable dogs using the Platelet Function Analyzer-200 (PFA-200) P2Y cartridge; further, we aimed to assess the utility of hematocrit (HCT), platelet count (PLT), prothrombin time ...
Joon-Ho Shin, Hyun-Jung Han, Hyun-Jung Han   +2 more
doaj   +1 more source

Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II trials [PDF]

, 2009
<p><b>Background and Purpose:</b> A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies.</p> <p><b>Methods:</b> We examined patients with
Cucchiara, B., Demchuk, A., Kasner, S.E., Lees, K.R., Levine, S.R., Lyden, P., Messe, S.R., Sansing, L., Tanne, D.   +8 more
core   +1 more source

The Australia and New Zealand Diabetic and Ischaemic Foot Outcomes Study (ANZDIFOS)

ANZ Journal of Surgery, EarlyView.
ABSTRACT Objective There is limited high‐quality data on the factors that contribute to limb loss in patients with diabetes‐related foot disease (DFD) in New Zealand and Australia. Furthermore, wound, ischaemia and foot infection (WIfI) staging has not been validated in the Australasian cohort.
Odette Hart, Philip Allan, Shirley Jansen, Robert Fitridge, Claire Murray, Mendel Baba, Prue Cowled, Neil McMillan, Manar Khashram   +8 more
wiley   +1 more source

Omega-3 fatty acid ethyl esters do not improve clopidogrel associated P2Y12 inhibition in stroke patients

Neurology International, 2015
The specific action of omega-3 fatty acid ethyl esters (OFA) in preventing cerebrovascular disease remains unknown, but research has demonstrated multiple possible mechanisms.
Ping Li, Haris Kamal, Melissa Baxter, Bijal K. Mehta   +3 more
doaj   +1 more source

Effects of the atorvastatin and clopidogrel combination therapy on statin bioavailability and platelet function of patients with stable coronary disease [PDF]

, 2010
BACKGROUND: Atorvastatin 80 mg is recommended in patients with coronary artery disease to reduce cardiovascular events, however, there is controversy regarding the pharmacokinetic interactions between high doses of statins and the concomitant use of ...
Barbosa, Simone Pinto de Melo, Bianco, Henrique Tria, Carvalho, Antonio Carlos, Chen, Lu Chi, Fischer, Simone Cristina Matheus, Fonseca, Francisco Antonio Helfenstein, França, Carolina Nunes, Ilha, Jaime, Izar, Maria Cristina de Oliveira, Kasmas, Soraia Hani, Nucci, Gilberto de, Pinheiro, Luiz Fernando Muniz, Póvoa, Rui Manuel dos Santos   +12 more
core   +2 more sources

The impact of systemic long‐term medications for the development of age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose Age‐related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long‐term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and ...
Hanna Heloterä, Reijo Sund, Toni Rikkonen, Kai Kaarniranta   +3 more
wiley   +1 more source